P06.12: Monozygotic twin pregnancy discordant for partial trisomy 13

2010 ◽  
Vol 36 (S1) ◽  
pp. 191-191
Author(s):  
R. Gerychova ◽  
E. Racanska ◽  
R. Gaillyova ◽  
J. Kadlecova
Keyword(s):  
Twin Pregnancy ◽  
Partial Trisomy ◽  
Monozygotic Twin ◽  
Trisomy 13

The link between hidradenitis suppurativa and phylloid hypomelanosis in partial trisomy‐13 mosaicism: New evidences and further genetic/pathogenetic insights

2021 ◽  
Author(s):  
Riccardo Forconi ◽  
Stefania Bigoni ◽  
Lucrezia Pacetti ◽  
Cristina Host ◽  
Natale Schettini ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Partial Trisomy ◽  
Trisomy 13

77 Monozygotic Twin Calves Production by Blastomere Separation Technique with Commercial Well-of-the-Well Culture Dish

2018 ◽  
Vol 30 (1) ◽  
pp. 177
Author(s):  
Y. Hashiyada ◽  
Y. Aikawa ◽  
H. Matsuda ◽  
T. Yamanouchi ◽  
Y. Goto ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Embryo Transfer ◽  
Twin Pregnancy ◽  
Small Body ◽  
Fetal Loss ◽  
Monozygotic Twin ◽  
Gestation Length ◽  
Culture Dish ◽  
Significant Difference

Monozygotic twin bovine embryos can be produced by blastomere separation of 2-cell embryos and commercial well-of-the-well (WOW) culture dish (Hashiyada et al. 2016 Reprod. Fertil. Dev. 28, 178) obtaining 60% and 48% of blastocyst formation and monozygotic blastocyst pairs, respectively. The present study was conducted to evaluate the fertility of blastocysts derived from this production system in Japanese Black beef cattle. Embryos were produced using oocytes collected by ovum pick-up technique. TCM-199 supplemented with 5% calf serum (CS), Brackett-Oliphant solution supplemented with 10 mg mL−1 BSA, and CR1aa containing 5% CS, were used for each culture step: in vitro maturation, fertilization, and culture (IVM,IVF, and IVC). Two-cell stage embryos were obtained 24 to 27 h post-insemination. Zonae pellucidae were removed by exposure to 0.25% pronase. Then, embryos were separated into blastomeres by gentle pipetting in IVC medium. Each blastomere was introduced into a single conical microwell of 25 wells, each having a diameter and depth of ~287 μm and 168 μm (Dai Nippon Printing, Tokyo, Japan). Blastomeres in wells were cultured covered with a droplet of 2.5 μL of IVC medium/well. The developed blastocysts in pairs on 7 days post-insemination were used for transfer. Single embryos of monozygotic twin embryos were transferred to Japanese Black cattle with a generally small body frame to produce twin calves from a set of recipients. Twin embryos were transferred in pairs to unilateral of uterus of non-lactating Holstein cows. Pregnancy and twin pregnancy were determined at 30 days of gestation by ultrasonography and were reconfirmed at 60 days with detection of fetal loss. Statistical significance was analysed by Fisher’s exact test. There was no significant difference in pregnancy rate or twin pregnancy rate between single embryo transfer (7/14, 50% and 2/7, 28.6%) and twin embryo transfer (9/21, 42.9% and 4/21, 19%). In either transfer method, fetal loss was not observed in diagnosis carried out at 60 days by ultrasonography. To date, 2 pairs of twin calves have been obtained from twin pregnant cows by twin embryo transfer within the normal range of gestation length (286 and 288 days) and birth weight (31-40 kg). These results indicate that blastocysts developed from blastomeres separated from 2-cell embryos by culturing with commercial WOW culture dish had fertility similar to that of intact embryos derived from standard in vitro culture and further demonstrate the possibility of production of normal twin calves.

Familial translocation leading to partial trisomy 13: Report of three cases

1984 ◽  
Vol 51 (4) ◽  
pp. 481-487 ◽  
Author(s):  
S. A. Tharapel ◽  
R. C. Lewandowski ◽  
M. K. Kukolich
Keyword(s):  
Partial Trisomy ◽  
Trisomy 13 ◽  
Familial Translocation

Microsurgical bisection of porcine morulae and blastocysts to produce monozygotic twin pregnancy

1989 ◽  
Vol 23 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Hiroshi Nagashima ◽  
Yukio Kato ◽  
Shyoso Ogawa
Keyword(s):  
Twin Pregnancy ◽  
Monozygotic Twin

scholarly journals Prenatal Sacrococcygeal Teratoma Diagnosed in a Fetus with Partial Trisomy 13q22

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Shana S. Dalal ◽  
Teresa Berry ◽  
Veronica Maria Pimentel
Keyword(s):  
Chromosomal Abnormalities ◽  
Partial Trisomy ◽  
Copy Number Gain ◽  
Trisomy 13 ◽  
Sacrococcygeal Teratoma ◽  
Structural Abnormality ◽  
Fetal Autopsy ◽  
Chromosome 13 ◽  
Cell Free Fetal Dna ◽  
Complex Structural

Sacrococcygeal teratoma is a rare neoplasm that arises from a totipotent stem cell in Henson’s node. It has rarely been associated with chromosomal abnormalities. We present a unique case of a 25-year-old primigravida at 19 weeks and 5 days of gestation found to have an exophytic complex mass with cystic and solid components in the sacral region. This mass was consistent with a sacrococcygeal teratoma. The patient had originally declined genetic screening. After the ultrasound and genetic counseling, she opted to have cell-free fetal DNA screening that was positive for Trisomy 13. Amniocentesis was performed to confirm the diagnosis. The karyotype demonstrated an abnormality of chromosome 13 and microarray demonstrated a complex structural abnormality of chromosome 13 with large regions of copy number gain. The patient underwent a dilation and evacuation at 23 weeks and 2 days. No fetal autopsy was done. This is a case of a prenatally diagnosed sacrococcygeal teratoma associated with Trisomy 13. It illustrates the diagnostic importance of amniocentesis in setting of fetal anatomical abnormalities on ultrasound. For patients who are reluctant to undergo amniocentesis, cell-free DNA results may provide the additional evidence of the need for diagnostic tests.

Partial trisomy 13 in a case of Cyclopia with 13/14 translocation

2008 ◽  
Vol 5 (3) ◽  
pp. 218-222 ◽  
Author(s):  
D. N. Singh ◽  
R. A. Wiscovitch ◽  
R. A. Osborne ◽  
G. R. Hennigar
Keyword(s):  
Partial Trisomy ◽  
Trisomy 13

scholarly journals Successful monozygotic twin pregnancy fathered by a male 46,XY true hermaphrodite

2011 ◽  
Vol 22 (1) ◽  
pp. 80-82 ◽  
Author(s):  
Johnny S. Younis ◽  
Orit Radin ◽  
Hedviga Kerner ◽  
Moshe Ben-Ami
Keyword(s):  
Twin Pregnancy ◽  
Monozygotic Twin ◽  
True Hermaphrodite
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