scholarly journals P17.17: Genetic recurrent risk of some urinary tract abnormality: is it possible to make a screening

2009 ◽  
Vol 34 (S1) ◽  
pp. 246-246
Author(s):  
L. Giorgi ◽  
F. Mecacci ◽  
P. Ciolini
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Abnormality ◽  
Tract Abnormality

Outcome of Renal Transplantation in Children With Low Urinary Tract Abnormality

2005 ◽  
Vol 37 (7) ◽  
pp. 3071-3074 ◽  
Author(s):  
H. Otukesh ◽  
M. Sharifian ◽  
N. Simfroosh ◽  
A. Basiri ◽  
R. Hoseini ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Urinary Tract ◽  
Urinary Tract Abnormality ◽  
Tract Abnormality

scholarly journals Clinical and laboratory features of the course of the urinary tract infection among children in the first three years of life at the current stage

2022 ◽  
pp. 41-45
Author(s):  
A. Nее ◽  
E. V. Sergeeva ◽  
O. G. Bykova ◽  
O. V. Semeshina
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
System Development ◽  
Urinary System ◽  
Urinary Tract Abnormality ◽  
Second Child ◽  
Tract Disease ◽  
Renal Infection ◽  
Current Stage

Objective: To study main clinical and laboratory peculiarities of the course of urinary tract disease among children aged from newborns to 3 years old.Methods: Research design is a prospective controlled clinical research. 102 (60.71±3.77 %) children having urinary tract infection without accompanying abnormalities of the urinary system development were included in the first group. 66 (39.29±3.77 %) children having infection of the urinary tract amid congenital kidney defect.Results: Comparative evaluation of the results of complex examination of both groups showed that urinary tract infection is characterized by intoxication, pain and dysuric syndroms. The presence of accompanying kidneys and urinary tract abnormality development defined the latent course of the disease in every second child (59.09%) and supports the early development of renal infection (during first six months after birth).Conclusions: It’s necessary to conduct the search of diagnostics markers and predictors of the infection of the urinary tract among children of the first years of life, especially if there is an abnormality of the organs of urinary system.

Prevention of Recurrent Urinary Tract Infections in Girls

PEDIATRICS ◽  
1977 ◽  
Vol 59 (4) ◽  
pp. 562-565
Author(s):  
Jacob A. Lohr ◽  
Donna H. Nunley ◽  
Stuart S. Howards ◽  
Raymond F. Ford
Keyword(s):  
Urinary Tract ◽  
Adverse Reactions ◽  
Low Dose ◽  
Double Blind ◽  
Urinary Tract Abnormality ◽  
History Of ◽  
The Difference ◽  
Tract Infections ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Eighteen girls between the ages of 3 and 13 years—with a history of at least three culture-documented episodes of bacteriuria in the previous year, but without radiologic evidence of major urinary tract abnormality—were placed on a double-blind, crossover study comparing the effectiveness of nitrofurantoin macrocrystals against a placebo in preventing the recurrence of bacteriuria. Each child was placed on a daily low dose of nitrofurantoin (1.2 to 2.4 mg/kg/day) or an identical-appearing placebo for six months. Each child was then placed on the opposite capsule for a similar period. There were 35 episodes of bacteriuria (4.2 episodes/patient/yr) in the patients taking the placebo, which compared with a rate of 3.8 episodes/patient/yr during the year prior to the study. Only two episodes (0.2 episodes/patient/yr) occurred in the patients taking the drug. The difference in the rate of recurrent bacteriuria between the girls on placebo and on medication is significant at the 0.01 level using the Wilcoxin matched-pairs test. There were no adverse reactions to the drug. Nitrofurantoin macrocrystals in a single daily low dose appear to be a safe, effective method of preventing recurrent bacteriuria in girls at high risk.

Vesico-ureteric reflux and urinary tract development in the Pax21Neu+/− mouse

2007 ◽  
Vol 293 (5) ◽  
pp. F1736-F1745 ◽  
Author(s):  
Inga J. Murawski ◽  
David B. Myburgh ◽  
Jack Favor ◽  
Indra R. Gupta
Keyword(s):  
Urinary Tract ◽  
Bladder Wall ◽  
Delayed Union ◽  
Metanephric Mesenchyme ◽  
Ureteric Bud ◽  
Urinary Tract Abnormality ◽  
Mesonephric Duct ◽  
Renal Coloboma Syndrome ◽  
Tract Infections ◽  
Dominant Condition

Vesico-ureteric reflux (VUR) is a urinary tract abnormality that affects roughly one-third of patients with renal-coloboma syndrome, an autosomal dominant condition caused by a mutation in PAX2. Here, we report that a mouse model with an identical mutation, the Pax2 1Neu+/− mouse, has a 30% incidence of VUR. In VUR, urine flows retrogradely from the bladder to the ureter and is associated with urinary tract infections, hypertension, and renal failure. The propensity to reflux in the Pax2 1Neu+/− mouse is correlated with a shortened intravesical ureter that has lost its oblique angle of entry into the bladder wall compared with wild-type mice. Normally, the kidney and urinary tract develop from the ureteric bud, which grows from a predetermined position on the mesonephric duct. In Pax2 1Neu+/− mice, this position is shifted caudally while surrounding metanephric mesenchyme markers remain unaffected. Mutant offspring from crosses between Pax2 1Neu+/− and Hoxb7/GFP+/− mice have delayed union of the ureter with the bladder and delayed separation of the ureter from the mesonephric duct. These events are not caused by a change in apoptosis within the developing urinary tract. Our results provide the first evidence that VUR may arise from a delay in urinary tract maturation and an explanation for the clinical observation that VUR resolves over time in some affected children.

scholarly journals Prevalence of urinary tract infection in malnourished children aged 6 months to 5 years attending tertiary care centre

2019 ◽  
Vol 6 (5) ◽  
pp. 1814
Author(s):  
Senthil Kumar A. ◽  
Thannoli Gowthami Gowrinathan
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urine Culture ◽  
Tertiary Care ◽  
Causative Organism ◽  
Klebsiella Pneumonia ◽  
Urinary Tract Abnormality ◽  
Malnourished Children ◽  
Sensitivity Pattern

Background: Infections are more common in malnourished children, as result of impaired immunity. Unexplained fever and failure to thrive are the common presenting features of urinary tract infection (UTI) in children. In malnourished children, UTI is mostly asymptomatic and is leading to pyelonephritis and renal scarring. The study was done with the aim to evaluate and find out the prevalence of urinary tract infection in malnourished children between 6 months to 5 year and to find out the causative organism and antibiotic sensitivity pattern.Methods: A total of 180 cases of malnourished children were enrolled and clean catch midstream urine sample was collected for urine culture, according to WHO criteria of malnutrition. Children with urinary tract abnormality were excluded from the study. Renal USG was done in all urine culture positive cases.Results: Total of 174 cases was present after exclusion. Of 174 children, 27 (15.5%) children were having UTI. In this study, 37% of children are asymptomatic. E. coli is the commonest organism causing UTI 16 (59%). Other organism are Klebsiella pneumonia 4 (14.9%), Proteus mirabilis 3 (11.1%), and Pseudomonas 3 (11.1%). The order of antimicrobial sensitivity pattern was amikacin (100%)> ciprofloxacin (81.4%)> cefotaxime (7%). Other common drugs have developed resistance to these organisms.Conclusions: Our observations conclude that malnourished children with fever of unknown origin are at risk of UTI. Hence, urine analysis and culture tests are to be done to all malnutrition cases for assisting to diagnose the bacterial infection and providing the appropriate treatment.

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