scholarly journals P15.11: Trends in prenasal thickness, nasal bone length and nuchal fold thickness measurements in second and third trimester Down syndrome fetuses

2009 ◽  
Vol 34 (S1) ◽  
pp. 235-235
Author(s):  
F. I. Vos ◽  
E. A. de Jong-Pleij ◽  
E. Timmerman ◽  
L. R. Pistorius ◽  
E. Pajkrt ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
Third Trimester ◽  
Bone Length ◽  
Nasal Bone Length ◽  
Thickness Measurements

Trends in Serial Measurements of Ultrasound Markers in Second and Third Trimester Down Syndrome Fetuses

2015 ◽  
Vol 38 (1) ◽  
pp. 48-54 ◽  
Author(s):  
F.I. Vos ◽  
E.A.P. De Jong-Pleij ◽  
M. Bakker ◽  
E. Tromp ◽  
C.M. Bilardo
Keyword(s):  
Down Syndrome ◽  
Heart Defects ◽  
Nasal Bone ◽  
Third Trimester ◽  
Bone Length ◽  
Normal Ranges ◽  
Nasal Bone Length ◽  
Serial Measurements ◽  
Space Ratio ◽  
Median Interval

Objectives: To evaluate trends of nasal bone length (NBL), prenasal thickness (PT), nuchal fold (NF), prenasal thickness to nasal bone length (PT-NBL) ratio, and prefrontal space ratio (PFSR), measured serially in second- and third-trimester Down syndrome (DS) fetuses. Methods: Prenatal databases were searched for cases of continuing DS pregnancies with serial measurements, taken at least two weeks apart. Trends were plotted on previously reported normal ranges. Results: Serial measurements were available in 25 Down syndrome fetuses. Median gestational age (GA) was 25 weeks; average number of visits per case was 2.44, with a median interval of 39 days between investigations. In DS fetuses, NBL and PT showed fairly stable trends with gestation. PFSR, but especially NF, had a more unpredictable trend. The PT-NBL ratio was the most stable marker, remaining unchanged in 95% of cases. NBL, PT, and NF showed more deviance from the normal range with advancing gestation, but MoM values remained stable. All but two fetuses had ultrasound markers or structural anomalies, especially heart defects. Conclusions: The PT-NBL ratio is the most constant DS marker throughout gestation, following a predictable trend.

News methods for second trimester screening of Down syndrome: statistical analysis of the use of nasal bone length and prenasal thickness

2014 ◽  
Vol 155 (47) ◽  
pp. 1876-1881
Author(s):  
Károly Szili ◽  
Andrea Szabó ◽  
Melinda Vanya ◽  
György Bártfai ◽  
János Szabó
Keyword(s):  
Down Syndrome ◽  
Statistical Methods ◽  
Prenatal Screening ◽  
Nasal Bone ◽  
Tissue Thickness ◽  
Bone Length ◽  
Box Plots ◽  
Soft Tissue Thickness ◽  
Nasal Bone Length ◽  
Thickness Measurements

Introduction: Sonographic measurements of nasal bone length and prenasal soft tissue thickness are ultrasonographic methods for prenatal screening of Down syndrome. Aim: The aim of the authors was to create a local normogram for nasal bone length and prenasal soft tissue thickness measurements and to test the performance of different statistical methods. Method: Euploid (N = 1500) and trisomy 21 foetuses (N = 10) studied between April 2008 and December 2013 were included. Nasal bone length and prenasal thickness measurements were performed at the Medisono Fetal and Maternal Health Research Centre, Szeged, and cytogenetic tests were performed at the Department of Medical Genetics, University of Szeged, Hungary. Normograms were created with different number of patients (N = 100, 300, 500, 750. 1000 and 1500) and using 3 different statistical methods (linear regression, square-based regression, and box-plot analysis). Results: The results indicated that at least 1000 measurements are strongly recommended for the normograms. The increase of patient number improved the efficacy of the normograms in each of the 3 statistical methods used for analysis. In general practice box-plots provides a better performance over the other screening methods. However, advanced level screening requires local linear normograms for the best screening results. Conclusion: The use of box-plots is recommended for the use in the daily practice but regression-based normograms are necessary for advanced prenatal screening. Orv. Hetil., 2014, 155(47), 1876–1881.

scholarly journals 350: Observed:expected ratios: assessment of nasal bone length for second-trimester Down syndrome screening in a user-friendly fashion

2011 ◽  
Vol 204 (1) ◽  
pp. S143
Author(s):  
Jennifer McNamara ◽  
Harish Sehdev ◽  
Alison Cahill ◽  
Linda Odibo ◽  
George Macones ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
Second Trimester ◽  
Bone Length ◽  
Nasal Bone Length ◽  
User Friendly ◽  
Down Syndrome Screening

scholarly journals Nasal bone length: prenasal thickness ratio: a strong 2D ultrasound marker for Down syndrome

2014 ◽  
Vol 34 (12) ◽  
pp. 1139-1145 ◽  
Author(s):  
Andrea Szabó ◽  
Károly Szili ◽  
János Tamás Szabó ◽  
János Sikovanyecz ◽  
Dóra Isaszegi ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Nasal Bone ◽  
Thickness Ratio ◽  
Bone Length ◽  
2D Ultrasound ◽  
Nasal Bone Length

Prenasal thickness-to-nasal bone length ratio: a strong and simple second- and third-trimester marker for trisomy 21

2011 ◽  
Vol 39 (2) ◽  
pp. 185-190 ◽  
Author(s):  
E. A. P. De Jong-Pleij ◽  
F. I. Vos ◽  
L. S. M. Ribbert ◽  
L. R. Pistorius ◽  
E. Tromp ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
Nasal Bone ◽  
Length Ratio ◽  
Third Trimester ◽  
Bone Length ◽  
Nasal Bone Length
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