scholarly journals P11.17: Adding tricuspid regurgitation (TR) to the first trimester protocol did not affect the overall screening performance of the first trimester screening (FTS) test

2009 ◽  
Vol 34 (S1) ◽  
pp. 222-223
Author(s):  
H. F. Yazicioglu ◽  
N. Gezer Kan ◽  
Z. Ipek ◽  
A. Kan
Keyword(s):  
Tricuspid Regurgitation ◽  
First Trimester ◽  
First Trimester Screening ◽  
Screening Performance ◽  
Trimester Screening

scholarly journals Combined First-Trimester Screening in Northern Finland: Experiences of the First Ten Years

2014 ◽  
Vol 8 ◽  
pp. CMRH.S14958
Author(s):  
Merilainen Anna ◽  
Peuhkurinen Sini ◽  
Honkasalo Timppa ◽  
Laitinen Paivi ◽  
Kokkonen Hannaleena ◽  
...  
Keyword(s):  
Detection Rate ◽  
False Positive Rate ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
First Trimester ◽  
First Trimester Screening ◽  
Invasive Procedures ◽  
Screening Performance ◽  
Positive Rate ◽  
Trimester Screening

Objective To evaluate the efficacy of first trimester combined screening for Down's syndrome in Northern Finland during the first 10 years of practice. Methods During 1 January 2002 to 31 December 2011, 47,896 women participated voluntarily in combined screening during first trimester. The risk cutoff was 1:250. The study period was divided into two time periods; 2002-2006 and 2007-2011. Results During the first half of the study period, the detection rate (DR) was 77.3% with a 4.9% false-positive rate (FPR). During the latter half, the DR was 77.1% with a 2.8% FPR. Conclusions An important issue is the number of invasive procedures needed to detect one case of Down's syndrome. The screening performance improved markedly in the latter five years period since the FPR lowered from 4.9% to 2.8% and the number of invasive procedures needed to detect one case of Down's syndrome lowered from 15 to 11.

Combined screening test for trisomy 21 – is it as efficient as we believe?

2017 ◽  
Vol 45 (2) ◽  
Author(s):  
Marcin Wiechec ◽  
Agnieszka Nocun ◽  
Anna Knafel ◽  
Ewa Wiercinska ◽  
Jiri Sonek ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
Absolute Risk ◽  
False Positive Rate ◽  
First Trimester ◽  
First Trimester Screening ◽  
Screening Performance ◽  
The Us ◽  
Positive Rate ◽  
Trimester Screening ◽  
The One

AbstractObjectives:To compare two first-trimester screening strategies: traditional combined screening and the one based on ultrasound markers only. We investigated the effect of maternal age (MA) on the screening performance of both of these strategies.Methods:This was a prospective observational study based on a non-selected mixed-risk population of 11,653 women referred for first-trimester screening. The study population was divided in two groups: combined screening (CS) and ultrasound-based screening (US). Absolute risk was calculated to determine the influence of MA on screening performance.Results:The CS arm comprised 5145 subjects including 51 cases of trisomy 21 (T21), and the US arm comprised 5733 subjects including 87 subjects with T21. Seven hundred and seventy-five subjects were excluded from the study. For a false positive rate (FPR) of 3%, the detection rate (DR) of T21 in CS arm was 78% vs. 90% in US arm. For 5% FPR, DR was 84% and 94% in CS and US arm, respectively. MA had an influence on DR positive rates in CS: both DR and FPR for T21 increased with advance in MA.Conclusions:The US protocol showed higher DR of T21 compared to the CS one. It may be considered as a viable alternative to CS for T21 where access to biochemical testing is limited.

Contribution of Fetal Tricuspid Regurgitation in First-Trimester Screening for Major Cardiac Defects

2011 ◽  
Vol 117 (6) ◽  
pp. 1384-1391 ◽  
Author(s):  
Susana Pereira ◽  
Ramesh Ganapathy ◽  
Argyro Syngelaki ◽  
Nerea Maiz ◽  
Kypros H. Nicolaides
Keyword(s):  
Tricuspid Regurgitation ◽  
First Trimester ◽  
First Trimester Screening ◽  
Cardiac Defects ◽  
Trimester Screening

First-Trimester Screening for Down Syndrome with Serum Sampling at Different Gestational Ages: The Effect on Screening Performance

2014 ◽  
Vol 36 (4) ◽  
pp. 293-298 ◽  
Author(s):  
Melanie A.J. Engels ◽  
Jos W.R. Twisk ◽  
Marinus A. Blankenstein ◽  
John M.G. van Vugt
Keyword(s):  
Down Syndrome ◽  
First Trimester ◽  
First Trimester Screening ◽  
Screening Performance ◽  
Trimester Screening
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