scholarly journals P205: Isolated fetal hypoplastic left heart syndrome: sonographic evaluation of fetal growth and Doppler blood flow

2003 ◽  
Vol 22 (S1) ◽  
pp. 125-125
Author(s):  
C. Montoneri ◽  
C. Exacoustos ◽  
C. M. R. Amoroso ◽  
I. Oronzi ◽  
D. Arduini
Keyword(s):  
Blood Flow ◽  
Hypoplastic Left Heart Syndrome ◽  
Fetal Growth ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Sonographic Evaluation ◽  
Left Heart Syndrome

scholarly journals Myocardial blood flow and viability in children post palliation of hypoplastic left heart syndrome assessed with MRI

2015 ◽  
Vol 17 (S1) ◽  
Author(s):  
Philip Wegner ◽  
Michael Jerosch-Herold ◽  
Christopher Hart ◽  
Eileen Pardun ◽  
Hans-Heiner Kramer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Hypoplastic Left Heart Syndrome ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Left Heart Syndrome

scholarly journals Placental and fetal characteristics of the Ohia mouse line recapitulate outcomes in human hypoplastic left heart syndrome

2020 ◽  
Author(s):  
Rebecca L Wilson ◽  
Weston Troja ◽  
Jennifer Courtney ◽  
Helen N Jones
Keyword(s):  
Mouse Model ◽  
Mrna Expression ◽  
Hypoplastic Left Heart Syndrome ◽  
Fetal Growth ◽  
Fetal Weight ◽  
Left Heart ◽  
Heterozygous Genotype ◽  
Placental Development ◽  
Hypoplastic Left Heart ◽  
Left Heart Syndrome

AbstractCongenital heart defects (CHDs) are one of the most common birth defects worldwide. The morbidity and mortality associated with these defects is compounded by increased frequency of fetal growth abnormalities in the newborns. Inappropriate placental development and function has been implicated as a contributing factor to poor fetal growth in pregnancies complicated by CHDs however, the exact mechanisms are poorly understood. In the Ohia mouse model of hypoplastic left heart syndrome (HLHS), the double homozygous genotype had previously been shown to be embryonically lethal at mid-pregnancy; a time in which optimal establishment of the placenta is crucial to fetal survival. We aimed to characterize placental and fetal growth and development in the double heterozygous genotype to determine whether the genetic mutations associated with HLHS in the Ohia mouse also affect the placenta. The frequency of fetuses with reduced weight near term was shifted in the double heterozygous genotype compared to wildtype fetuses. This shift in fetal weight distribution was associated with reduced fetal capillary density in the placentas of the double heterozygotes as well as a reduction in placental mRNA expression of angiogenic factors placenta growth factor (Pgf) and fms-like tyrosine kinase-1 (Flt1) suggesting abhorrent placental angiogenesis. Positive correlations were observed between fetal weight and placenta mRNA expression of several nutrient transporters in the double heterozygous genotype but not observed in the wildtype. This data shows changes to placental angiogenesis and nutrient transport that are likely to contribute to inadequate fetal growth in the Ohia mouse model. Such differences are similar to findings in studies of human placentas from pregnancies with a fetus with HLHS and highlights the importance of this mouse model in continuing to understand the link between placental development and CHDs such as HLHS.New and NoteworthyWe used the Ohia mouse line, which is characterized with a hypoplastic left heart syndrome (HLHS)-like phenotype to investigate the contribution of placental development and function to fetal growth abnormalities associated with congenital heart defects (CHDs). We demonstrate an increase in the frequency of fetuses with lower fetal weight in the double heterozygous genotype which is associated with abnormalities to the placental microstructure, reduced placental fetal capillary density and placental mRNA expression of angiogenic factors Pgf and Flt1. These results are supported by similar studies of human placentas from HLHS pregnancies and highlights the usefulness of this model in furthering our understanding of abnormal fetal growth in CHDs.

Understanding the Hybrid Stage I Approach for Hypoplastic Left Heart Syndrome

2016 ◽  
Vol 36 (5) ◽  
pp. 48-55
Author(s):  
Sharon L. Cheatham ◽  
Grace M. Deyo
Keyword(s):  
Blood Flow ◽  
Pulmonary Artery ◽  
Hypoplastic Left Heart Syndrome ◽  
Main Pulmonary Artery ◽  
Median Sternotomy ◽  
Stage I ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Cavopulmonary Anastomosis ◽  
Left Heart Syndrome

Hybrid stage I palliation combines cardiothoracic surgery and interventional transcatheter procedures for treatment of hypoplastic left heart syndrome. The approach is an alternative to the Norwood procedure, the traditional first stage of surgical palliation. Hybrid stage I palliation involves placing bilateral branch pulmonary artery bands and a patent ductus arteriosus stent through a median sternotomy, performed without cardiopulmonary bypass. The purpose of the bands is to control blood flow to the lungs and protect the pulmonary bed while the stent sustains systemic cardiac output. A balloon atrial septostomy is performed to create an atrial septal defect for unobstructed blood flow from the left atrium to the right atrium. The second stage of palliative surgery is the comprehensive stage II, which incorporates removal of the stent and pulmonary artery bands, atrial septectomy, anastomosis of the diminutive ascending aorta to the main pulmonary artery, aortic arch augmentation, and bidirectional cavopulmonary anastomosis. The traditional Fontan procedure completes the series of palliation.

Mitral atresia with transposed great arteries and normal semilunar valves: a rare combination

2015 ◽  
Vol 26 (3) ◽  
pp. 599-601
Author(s):  
Gopalan Nair Rajesh ◽  
Sandeep Mohanan ◽  
Haridasan Vellani
Keyword(s):  
Blood Flow ◽  
Aortic Valve ◽  
Hypoplastic Left Heart Syndrome ◽  
Pulmonary Blood Flow ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Mitral Atresia ◽  
Rare Combination ◽  
Multiple Levels ◽  
Left Heart Syndrome

AbstractMitral atresia is commonly seen as a part of the spectrum of hypoplastic left heart syndrome, and it is usually associated with multiple levels of systemic outflow tract obstruction. Isolated mitral atresia with a normal aortic valve is extremely rare. We report the rare combination of mitral atresia, transposition of the great arteries, and unobstructed systemic and pulmonary blood flow.

Sign in / Sign up

Export Citation Format

Share Document