scholarly journals Reducing the cost of detection of congenital heart disease in fetuses of women with pregestational diabetes mellitus

2009 ◽  
Vol 33 (6) ◽  
pp. 676-682 ◽  
Author(s):  
L. S. Bernard ◽  
G. A. Ramos ◽  
V. Fines ◽  
A. D. Hull
Keyword(s):  
Diabetes Mellitus ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Pregestational Diabetes ◽  
The Cost

scholarly journals Congenital heart disease and the cost of mortality

Open Heart ◽  
2016 ◽  
Vol 3 (1) ◽  
pp. e000448 ◽  
Author(s):  
Richard J Czosek ◽  
Jeffery B Anderson
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
The Cost

Abstract 4680: Rapid Growth in Hospitalizations for Adults with Congenital Heart Disease in the United States

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Alexander R Opotowsky ◽  
Omar Siddiqi ◽  
Gary D Webb
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Complex Disease ◽  
The United States ◽  
Hospital Charges ◽  
Pediatric Care ◽  
Annual Number ◽  
Diagnostic Code ◽  
The Cost

Background: Adults with congenital heart disease (ACHD) constitute a growing population due to advances in pediatric care and diagnostic testing. This study aimed to better define the growth in ACHD hospitalizations and to provide data on the cost of hospitalization for these patients. Methods: We utilized data from the 1998 –2005 Nationwide Inpatient Survey, the largest all-payer nationally representative hospital discharge database, to analyze trends in ACHD hospitalizations. We included all patients over 17 years of age with Clinical Classification Software diagnostic code 213 (Cardiac and Circulatory Anomalies). National estimates of hospitalizations and hospital charges by year for ACHD diagnoses were calculated, as were equivalent estimates for specific subsets of patients. Results: The number of ACHD hospitalizations increased 67% between 1998 and 2005, from 53,212 to 88,610 per year. Over this period, the annual number of admissions increased for both simple (44,781 to 75,911) and complex diagnoses (8,431 to 12,699)(Table ). Patients 55 years or older made up approximately 51% of all ACHD patients, and 40% of those with complex disease. Rates of hospitalization increased similarly for patients under and over 55 years old among all diagnostic categories. Inpatient mortality decreased from 2.6+/−0.2% to 1.7+/−0.1% for simple diagnoses, and 4.4+/−0.5% to 3.7+/−0.4% for complex diagnoses. Mean hospital charges per hospitalization increased 66% from $21,485 to $35,565, and the estimated total national charges for these hospitalizations increased from $1.1 billion to $3.1 billion in 2005 (all in 1998 dollars). In 1998, admissions for ACHD accounted for 0.31% of estimated total national charges for hospitalizations of patients 18 years or older, as compared with 0.47% in 2005. Conclusions: There has been a striking increase in hospitalizations for ACHD, and the cost of these admissions is rising out of proportion to overall hospital costs. Number of Adult Congenital Heart Disease Admissions per Year

scholarly journals Echocardiographic Study of Congenital Heart Disease in Infants of Diabetic Mother

2019 ◽  
Vol 8 (1) ◽  
pp. 43-47
Author(s):  
Babita Khanal ◽  
Manoj Kumar Shrivastava ◽  
Prakash Kafle ◽  
Pushpa Kumari Shah
Keyword(s):  
Diabetes Mellitus ◽  
Congenital Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Congenital Heart ◽  
College Teaching ◽  
Maternal Diabetes ◽  
Diabetic Mother ◽  
Medical College ◽  
Maternal Diabetes Mellitus

Background: Maternal diabetes mellitus (DM) has been shown to be high risk factor for congenital anomalies. It carries 3-5 times higher risk of incidence compared to the general population. The aims of present study is to investigate and portray the incidence of congenital heart disease in infants of diabetic mothers and know the utility of echocardiography in the early diagnosis of CHD at Nobel Medical College teaching hospital, a tertiary care centre in the eastern part of Nepal and review the current literature. Material & Methods: This is a prospective observational study conducted in Nobel Medical College Teaching hospital, Kanchanbari, Biratnagar Nepal over the period of 12 months. A structured questionnaire was designed which included demographic profile and the Echocardiography findings. The collected data were analysed using window’s SPSS version 20. Results: In the present study of the total deliveries 1.99 % was diabetic mother comprising 208 deliveries.127 had undergone echocardiography in which 10.2 % (n=13) had anomalies. One hundred sixteen were term and 11 were preterm. PDA was the most common anomaly (38.4%) followed by VSD (23.1%) and HCM (15.4%). Conclusion: With the review of current literature it has been found that maternal diabetes mellitus is a significant risk factor for congenital heart disease so it is suggested that the presence of diabetes mellitus in a pregnancy should be taken as a strong suspicious of having CHD and infants should be screened for the same .so as to diagnose the anomaly at the earliest possible.

scholarly journals Familial GATA6 mutation causing variably expressed diabetes mellitus and cardiac and renal abnormalities

2019 ◽  
Vol 2019 ◽  
Author(s):  
Yang Timothy Du ◽  
Lynette Moore ◽  
Nicola K Poplawski ◽  
Sunita M C De Sousa
Keyword(s):  
Diabetes Mellitus ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Umbilical Hernia ◽  
Congenital Heart ◽  
Monogenic Diabetes ◽  
Complex Congenital Heart Disease ◽  
List Type ◽  
Paternal Grandmother ◽  
Renal Abnormalities

Summary A 26-year-old man presented with a combination of permanent neonatal diabetes due to pancreatic aplasia, complex congenital heart disease, central hypogonadism and growth hormone deficiency, structural renal abnormalities with proteinuria, umbilical hernia, neurocognitive impairment and dysmorphic features. His older brother had diabetes mellitus due to pancreatic hypoplasia, complex congenital heart disease, hypospadias and umbilical hernia. Their father had an atrial septal defect, umbilical hernia and diabetes mellitus diagnosed incidentally in adulthood on employment screening. The proband’s paternal grandmother had a congenital heart defect. Genetic testing of the proband revealed a novel heterozygous missense variant (Chr18:g.19761441T>C, c.1330T>C, p.Cys444Arg) in exon 4 of GATA6, which is class 5 (pathogenic) using American College of Medical Genetics and Genomics guidelines and is likely to account for his multisystem disorder. The same variant was detected in his brother and father, but not his paternal grandmother. This novel variant of GATA6 likely occurred de novo in the father with autosomal dominant inheritance in the proband and his brother. The case is exceptional as very few families with monogenic diabetes due to GATA6 mutations have been reported to date and we describe a new link between GATA6 and renal pathology. Learning points: Monogenic diabetes should be suspected in patients presenting with syndromic features, multisystem congenital disease, neonatal-onset diabetes and/or a suggestive family history. Recognition and identification of genetic diabetes may improve patient understanding and empowerment and allow for better tailored management. Identification of a genetic disorder may have important implications for family planning.

scholarly journals Study of fetal 2D echo in pregnant women with diabetes and gestational diabetes mellitus

2019 ◽  
Vol 8 (11) ◽  
pp. 4213
Author(s):  
Priti A. Hatkar
Keyword(s):  
Diabetes Mellitus ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Right Atrium ◽  
Congenital Heart ◽  
Fetal Echocardiography ◽  
Tertiary Care ◽  
2D Echocardiography

Background: Diagnosis of diabetes in pregnancy is an important public health issue. Present study was done to study incidence of abnormal foetal 2D echocardiography in women with diabetes and gestational diabetes mellitus and to know their obstetric outcome.Methods: It is a prospective, observational study, which includes 80 patients. It was conducted at our tertiary care centre after the approval by ethics committee, and the results were analysed.Results: Out of 80 patients included, 77% women had GDM and rest 23% had DM. In this study, all patients had fetal 2D echocardiography done. 3 patients had report suggestive of congenital heart disease in the fetus. 1 of them was suggestive of TAPVC, 1 was suggestive of enlarged right atrium, 1 report was suggestive of VSD. Two of the abnormal fetal 2D echocardiography diagnosis of TAPVC and VSD was confirmed by neonatal 2D echo. One baby with Normal antenatal 2D echo had ASD on post-natal evaluation. The baby with antenataly enlarged right atrium had no cardiac anomaly on post-natal evaluation.Conclusions: Incidence of DM/GDM is increasing. As baby is likely to have congenital anomalies, out of which cardiac anomalies are most common, fetal echocardiography is a well-established, accurate, and safe method for diagnosing congenital heart disease. All the babies with abnormal fetal echocardiography need post-natal confirmation.

scholarly journals Hereditary pancreatic hypoplasia, diabetes mellitus, and congenital heart disease: a new syndrome?

1994 ◽  
Vol 31 (4) ◽  
pp. 331-333 ◽  
Author(s):  
T Yorifuji ◽  
M Matsumura ◽  
T Okuno ◽  
K Shimizu ◽  
T Sonomura ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Pancreatic Hypoplasia
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