First-trimester screening in pregnancies conceived by assisted reproductive technology: significance of gestational dating by oocyte retrieval or sonographic measurement of crown-rump length

2008 ◽  
Vol 32 (5) ◽  
pp. 612-617 ◽  
Author(s):  
A. C. Gjerris ◽  
A. Loft ◽  
A. Pinborg ◽  
A. Tabor ◽  
M. Christiansen
Keyword(s):  
Assisted Reproductive Technology ◽  
Oocyte Retrieval ◽  
First Trimester ◽  
Reproductive Technology ◽  
First Trimester Screening ◽  
Crown Rump Length ◽  
Trimester Screening

Normal values of cardiac axis (CA) measurements in healthy fetuses during the first trimester screening ultrasound

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Assaad Kesrouani ◽  
Wael Abdallah ◽  
Roland Kharrat ◽  
Elie Choueiry ◽  
Linda Daou ◽  
...  
Keyword(s):  
Normal Values ◽  
Middle Eastern ◽  
First Trimester ◽  
P Value ◽  
First Trimester Screening ◽  
Crown Rump Length ◽  
Middle Eastern Population ◽  
Trimester Screening ◽  
Heart Abnormalities ◽  
Screening Ultrasound

AbstractObjectivesTo report the normal fetal cardiac axis (CA) values at the time of the first trimester screening ultrasound.MethodsStandardized images and measurement of the CA were obtained from 100 healthy fetuses between 11+0 and 13+6 weeks of gestation along with the nucal thichkness (NT), Crown–rump length (CRL) and other measurements. We excluded cases with abnormal NT, later diagnosis of abnormalities, and suspected fetal cardiopathy during the pregnancy follow-up. Data analysis was performed after all the patients delivered and cardiopathy was excluded.ResultsCA was measurable in all the cases. Higher CRL was associated with a decrease in the CA. The mean ± SD embryonic/fetal CA was 48±5,2°, ranging from 39 to 60°, The 2.5 percentile was defined at 40° and the 97.5 percentile at 59°. The Pearson test resulted in a significant correlation between CA and CRL with a coefficient R of 70% and p-value <0.01.ConclusionsCA tends to decrease at the 11 to 13+6 gestational ages. We defined 2.5 and 97.5% curves for the normal values of CA in our Middle Eastern population. A larger study will be required to differentiate normal and abnormal values for the early detection of heart abnormalities.

Sensitivity of multiple first trimester sonomarkers in fetal aneuploidy detection

2015 ◽  
Vol 43 (3) ◽  
Author(s):  
Pharuhas Chanprapaph ◽  
Chitnapin Dulyakasem ◽  
Buraya Phattanchindakun
Keyword(s):  
Prenatal Diagnosis ◽  
First Trimester ◽  
Trisomy 13 ◽  
Ductus Venosus ◽  
Specific Marker ◽  
First Trimester Screening ◽  
Crown Rump Length ◽  
Fetal Aneuploidy ◽  
Single Marker ◽  
Trimester Screening

AbstractMultiple first trimester aneuploidy sonomarkers have been introduced recently.To evaluate the efficacy of first trimester sonomarkers in fetal aneuploidy detection without serum markers.There were entirely 280 fetuses with 11–13+6 weeks’ gestation (crown-rump -length between 45–84 mm) enrolled to assess nuchal translucency thickness (NT), nasal bone (NB), tricuspid regurgitation (TR) and ductus venosus (DV) flow. The performance of each single marker and multiple markers for major fetal aneuploidy screening were determined.Totally, 190 fetuses (67.85%) underwent invasive prenatal diagnosis with 14 major chromosome abnormalities identified including 4 cases of trisomy 21, 4 cases of trisomy 18, 3 cases of trisomy 13 and 3 cases of 45, XO. NT was the most accurate single marker with sensitivity of 71.43% and false-positive rate (FPR) of 4.14% while NB or TR was the most specific marker (99.6%) but lacked sensitivity. Among multiple first trimester-screening sonomarkers, NT plus TR evaluation were the most sensitive test (78.57%) with FPR of 4.76%.NT was the most accurate first trimester-screening marker for fetal aneuploidy. NT plus TR assessment as double-screening markers could improve the sensitivity by 7% leading to the lower number of unnecessary invasive prenatal diagnosis.

scholarly journals Impact of bias in crown-rump length measurement at first-trimester screening for trisomy 21

2012 ◽  
Vol 40 (2) ◽  
pp. 135-139 ◽  
Author(s):  
K. O. Kagan ◽  
M. Hoopmann ◽  
A. Baker ◽  
M. Huebner ◽  
H. Abele ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
First Trimester ◽  
Length Measurement ◽  
First Trimester Screening ◽  
Crown Rump Length ◽  
Trimester Screening
Sign in / Sign up

Export Citation Format

Share Document