P25.03: Relation between nuchal translucency thickness and prevalence of chromosomal defects, miscarriage, fetal death and major fetal abnormalities

2008 ◽  
Vol 32 (3) ◽  
pp. 398-398
Author(s):  
D. G. Iliescu ◽  
N. Cernea ◽  
L. Novac ◽  
S. Tudorache ◽  
A. Comanescu ◽  
...  
Keyword(s):  
Fetal Death ◽  
Nuchal Translucency ◽  
Fetal Abnormalities ◽  
Chromosomal Defects

Oligohydramnion in the First Half of Pregnancy in the Fetuses with Congenital Abnormalities: Ultrasound Diagnostics and Obstetric Outcomes

2021 ◽  
Vol 76 (4) ◽  
pp. 341-350
Author(s):  
Sergey M. Voevodin ◽  
Tatiana V. Shemanaeva ◽  
Alyona V. Serova
Keyword(s):  
Amniotic Fluid ◽  
Congenital Malformations ◽  
Fetal Death ◽  
Congenital Abnormalities ◽  
Neonatal Period ◽  
Perinatal Outcomes ◽  
Main Group ◽  
Obstetric Outcomes ◽  
Fetal Abnormalities ◽  
4D Ultrasound

Background.Oligohydramnion in the first half of pregnancy, combined with congenital abnormalities in the fetus has objective difficulties in diagnosis. The morphology features and type of defects associated with oligohydramnion, which manifests in the first half of pregnancy, are not sufficiently studied at the present stage. Aims to evaluate the clinical significance of diagnosing oligohydramnion in the first half of pregnancy in women with congenital fetal malformations. Materials and methods.The analysis of the course of pregnancy and perinatal outcomes in 77 women with low water content in combination with congenital malformations of the fetus and 72 patients with a normal amount of amniotic fluid and no congenital malformations of the fetus was performed. The patients of the main group were divided into two subgroups depending on the severity of oligohydramnion: the 1st subgroup (n = 54) patients with severe oligohydramnion and the 2nd subgroup (n = 23) patients with moderate oligohydramnion. The amount of amniotic fluid was determined by 3D/4D ultrasound (1321 weeks of gestation) and the structure of fetal abnormalities associated with oligohydramnion was analyzed. We evaluated perinatal outcomes in women with congenital malformations of the fetus in combination with oligohydramnion and the effect of its severity on the outcome of pregnancy. Results.In the main group (n = 77), fetal abnormalities were detected in patients: urinary system 39 (50.6%), respiratory system 4 (5.2%), heart 1 (1.3%), chromosomal and genetic abnormalities 14 (18.2%), central nervous system 3 (3.9%), osseous system 3 (3.9%), multiple 13 (16.9%). In the main group (n = 77), pregnancy was terminated for medical indications in 47 (61%) cases, in 6 (7.8%) spontaneous miscarriage occurred, in 5 (6.5%) antenatal fetal death. 19 (24.7%) children were born alive, and surgical treatment in the neonatal period was required in 8 (10.4%) cases. In the 1st subgroup (n = 54) in 53 (98.1%) cases, there was a loss of the fetus, in 1 (1.9%) the newborn died on the 9th day. In the 2nd subgroup (n = 23), fetal death occurred in 5 (21.7%) cases, 18 (78.3%) children were born alive, and 8 (44.4%) newborns were operated on in the neonatal period. In the control group, all pregnancies ended with the birth of healthy children. A decrease in ultrasound imaging of internal organs in the fetus was observed when a pregnant woman was obese (BMI more than 35). Conclusions.Oligohydramnion in the first half of pregnancy in combination with fetal malformation should be considered an extremely unfavorable clinical sign for the prognosis of pregnancy and the health of the fetus and newborn. 3D/4D ultrasound scanning allows you to reliably determine oligohydramnion in the first half of pregnancy, and the degree of its severity to assume the nature of complications.

Increased Nuchal Translucency as a Marker for Fetal Chromosomal Defects

1997 ◽  
Vol 337 (23) ◽  
pp. 1654-1658 ◽  
Author(s):  
Pekka Taipale ◽  
Vilho Hiilesmaa ◽  
Riitta Salonen ◽  
Pekka Ylöstalo
Keyword(s):  
Nuchal Translucency ◽  
Chromosomal Defects ◽  
Increased Nuchal Translucency

A mixture model of nuchal translucency thickness in screening for chromosomal defects: validation of a single operator dataset

2010 ◽  
Vol 30 (11) ◽  
pp. 1100-1106 ◽  
Author(s):  
A. Gasiorek-Wiens ◽  
S. Kotsis ◽  
I. Staboulidou ◽  
M. Stumm ◽  
R. D. Wegner ◽  
...  
Keyword(s):  
Mixture Model ◽  
Nuchal Translucency ◽  
Single Operator ◽  
Chromosomal Defects

Umbilical Cord Diameter at 11–14 Weeks of Gestation: Relationship to Nuchal Translucency, Ductus Venous Blood Flow and Chromosomal Defects

2006 ◽  
Vol 21 (4) ◽  
pp. 390-395 ◽  
Author(s):  
R. Axt-Fliedner ◽  
A. Schwarze ◽  
P. Kreiselmaier ◽  
M. Krapp ◽  
J. Smrcek ◽  
...  
Keyword(s):  
Blood Flow ◽  
Umbilical Cord ◽  
Venous Blood ◽  
Nuchal Translucency ◽  
Venous Blood Flow ◽  
Chromosomal Defects

A mixture model of nuchal translucency thickness in screening for chromosomal defects

2008 ◽  
Vol 31 (4) ◽  
pp. 376-383 ◽  
Author(s):  
D. Wright ◽  
K. O. Kagan ◽  
F. S. Molina ◽  
A. Gazzoni ◽  
K. H. Nicolaides
Keyword(s):  
Mixture Model ◽  
Nuchal Translucency ◽  
Chromosomal Defects

Causes of intrauterine fetal death are changing in recent years

2018 ◽  
Vol 46 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Hiroko Takita ◽  
Junichi Hasegawa ◽  
Masamitsu Nakamura ◽  
Tatsuya Arakaki ◽  
Tomohiro Oba ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Umbilical Cord ◽  
Medical Records ◽  
Fetal Death ◽  
Chromosomal Abnormalities ◽  
Intrauterine Fetal Death ◽  
Fetal Abnormalities ◽  
Perinatal Center ◽  
Umbilical Cord Entanglement ◽  
Velamentous Cord Insertion

AbstractObjective:To investigate, how causes of intrauterine fetal death (IUFD) have changed in recent years with the advancement of prenatal diagnosis at a single perinatal center in Japan.Methods:Medical records were retrospectively reviewed for all cases of IUFDs that occurred between 2001 and 2014. The most commonly associated causes of fetal deaths were compared between 2001–2007 and 2008–2014.Results:The number of IUFD after 20 weeks’ gestation/all deliveries in our center was 38/6878 cases (0.53%) in 2001–2007 and 35/7326 (0.48%) in 2008–2014. The leading cause of IUFD in 2001–2007 was fetal abnormalities (43.2%), the prevalence of which was only 8.6% in 2008–2014 (P<0.01). Meanwhile, the prevalence of umbilical cord abnormalities was relatively increased from 30.0% in 2001–2007 to 54.5% in 2008–2014 (P=0.06). In 2001–2007, chromosomal abnormalities were frequently observed (56% of IUFDs due to fetal abnormalities). Hyper-coiled cord (HCC) and umbilical ring constrictions were the most frequent cause of IUFD in both periods. The relatively decreased prevalence of IUFD due to velamentous cord insertion and umbilical cord entanglement, HCC and umbilical cord constriction was increased.Conclusions:The prevalence of IUFD due to fetal abnormalities was reduced, but IUFD associated with umbilical cord abnormalities tended to increase relatively.

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