scholarly journals First-trimester uterine artery resistance and maternal serum concentration of asymmetric dimethylarginine

2008 ◽  
Vol 31 (2) ◽  
pp. 153-157 ◽  
Author(s):  
F. Prefumo ◽  
B. Thilaganathan ◽  
G. S. Whitley
Keyword(s):  
Serum Concentration ◽  
Uterine Artery ◽  
Asymmetric Dimethylarginine ◽  
First Trimester ◽  
Maternal Serum

scholarly journals Potential screening strategies for early prediction of pre-eclampsia

2021 ◽  
Vol 10 (4) ◽  
pp. 1436
Author(s):  
Hymavathi K. ◽  
Sandhya Rani Davuluru ◽  
Sameera Shaik ◽  
Sahithi Kaviti
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Uterine Artery ◽  
Strong Association ◽  
First Trimester ◽  
Maternal Serum ◽  
Screening Tools ◽  
Early Prediction ◽  
Inhibin A ◽  
Study Results

Background: This study was conducted to evaluate the efficacy of different biochemical and biophysical markers in the early weeks of gestation as screening tools for early prediction of preeclampsia.Methods: This hospital-based prospective observational study conducted on 52 pregnant women, at less than 13 weeks of gestation were recruited. Maternal serum inhibin A and USG uterine artery PI levels were analyzed among the pregnant women who subsequently developed PE and compare with those who did not develop PE. Methods used for the detection of markers were: chemiluminescence immunoassay (CLIA) for serum inhibin A levels, and uterine artery Doppler velocimetry was done by PHILIPS HD11XE transabdominal ultrasound machine using a 4-6 MHz probe with the same sonographer.Results: The present study revealed a significant rise of inhibin A in preeclamptic women when compared to normotensive women (p<0.0001). The mean levels of 1st and 2nd trimester uterine artery PI significantly high in women who subsequently developed PE when compared to those who did not develop preeclampsia (p<0.0001). Study results showed a strong association between gestational age at delivery and neonatal outcome (neonatal birth weight and APGAR) with preeclampsia. The maternal serum inhibin A, and uterine artery PI found to have good sensitivity and specificity for early prediction of PE.Conclusions: Study concluded that the women who are prone to develop PE subsequently, had high levels of MAP, UAPI, inhibin A. In our setting, MAP, UAPI, inhibin A, appeared to be better screening modalities. Combination of the biochemical markers with the biophysical markers, demographic characteristics, and other novel markers will establish the effective screening models for early prediction of PE. Early identification of high-risk cases will offer an opportunity for prophylactic therapy, such as Low- dose Aspirin in selected groups of high-risk women screened in the first trimester, thus improving the maternal and perinatal outcome.

scholarly journals Uterine Artery Doppler in the Prediction of Preeclampsia and Adverse Pregnancy Outcome

2010 ◽  
Vol 4 (2) ◽  
pp. 117-122
Author(s):  
George Daskalakis ◽  
Aris Antsaklis
Keyword(s):  
Pregnancy Outcome ◽  
Uterine Artery ◽  
Adverse Pregnancy Outcome ◽  
False Positive Rate ◽  
First Trimester ◽  
Maternal Serum ◽  
Uterine Artery Doppler ◽  
Mortality And Morbidity ◽  
Increased Risk ◽  
Adverse Pregnancy

Abstract Preeclampsia and fetal growth restriction are major causes of perinatal mortality and morbidity. Several studies have shown that a generalized endothelial dysfunction is associated with these complications. Clinical trials have shown that pregnant women who demonstrate high resistance in uteroplacental blood flow are at higher risk for preeclampsia. Uterine artery Doppler studies both in the second and the first trimester can predict pregnancies at increased risk of the complications of impaired placentation. The sensitivity for predicting severe preeclampsia ranges between 80 and 90% for a false positive rate of 5 to 7%. Uterine artery Doppler screening at 20 to 24 weeks’ gestation is superior to first trimester screening, and appears to fulfill the requirements for a worthwhile screening test. Further research is needed to better assess the value of various combinations of uterine artery Doppler and maternal serum markers, for the prediction of adverse pregnancy outcome.

First trimester maternal serum PIGF, free β-hCG, PAPP-A, PP-13, uterine artery Doppler and maternal history for the prediction of preeclampsia

Placenta ◽  
2012 ◽  
Vol 33 (6) ◽  
pp. 495-501 ◽  
Author(s):  
G. Di Lorenzo ◽  
M. Ceccarello ◽  
V. Cecotti ◽  
L. Ronfani ◽  
L. Monasta ◽  
...  
Keyword(s):  
Uterine Artery ◽  
First Trimester ◽  
Maternal Serum ◽  
Maternal History ◽  
Uterine Artery Doppler ◽  
Β Hcg
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