scholarly journals OP25.07: Outcome of low PAPP-A pregnancies in a community-based first trimester screening program

2007 ◽  
Vol 30 (4) ◽  
pp. 544-544
Author(s):  
B. G. Hewitt ◽  
S. L. Barrett ◽  
C. Bower ◽  
N. C. Hadlow
Keyword(s):  
Screening Program ◽  
First Trimester ◽  
First Trimester Screening ◽  
Community Based ◽  
Trimester Screening

Non-invasive prenatal testing offered as part of a combined first-trimester screening program identifies tetrasomy 18p in a high-risk pregnancy

2016 ◽  
Vol 36 (12) ◽  
pp. 1112-1114 ◽  
Author(s):  
Dorte Launholt Lildballe ◽  
Ida Vogel ◽  
Ida Charlotte Bay Lund ◽  
Inger Stornes ◽  
Mette Warming Jørgensen ◽  
...  
Keyword(s):  
High Risk ◽  
Screening Program ◽  
Prenatal Testing ◽  
First Trimester ◽  
High Risk Pregnancy ◽  
First Trimester Screening ◽  
Non Invasive ◽  
Risk Pregnancy ◽  
Tetrasomy 18P ◽  
Trimester Screening

Detection of Fetal Structural Anomalies in a Basic First-Trimester Screening Program for Aneuploidy

2014 ◽  
Vol 33 (10) ◽  
pp. 1737-1745 ◽  
Author(s):  
Bryann Bromley ◽  
Thomas D. Shipp ◽  
Jennifer Lyons ◽  
Reshama S. Navathe ◽  
Yvette Groszmann ◽  
...  
Keyword(s):  
Screening Program ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
Structural Anomalies

Fine-tuning of routine combined first- trimester screening: The ratio of serum-free- beta-human chorionic gonadotropin (fβ-hCG) to pregnancy-associated plasma protein-A (PAPP-A) could improve performance of Down syndrome screening program, a retrospective cohort study in Iran

2020 ◽  
Vol 28 (3) ◽  
pp. 203-210
Author(s):  
Sarang Younesi ◽  
Mohammad Mahdi Taheri Amin ◽  
Pourandokht Saadati ◽  
Bahareh Yazdani ◽  
Soudabeh Jamali ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Screening Program ◽  
False Negative ◽  
False Negative Rate ◽  
First Trimester ◽  
Fine Tuning ◽  
Medical Laboratory ◽  
First Trimester Screening ◽  
Intermediate Group ◽  
Trimester Screening

OBJECTIVES: To evaluate the performance of the current national screening policy for Down syndrome (DS) in Iran and suggest a more efficient protocol with a wealth of a large series of first-trimester screening (FTS) data obtained from Nilou medical laboratory. To fulfill this aim, detection rate (DR), positive screening rate (PSR), false negative rate (FNR) and odds of being affected given a positive results (OAPR) were calculated at different cutoff risk. In the latest update of DS screening program in Iran, there is no place for intermediate group to be further investigated. Next, we proposed a novel parameter namely the ratio of fβ-hCG multiple of the median (MoM) value to PAPP-A MoM value to delicately categorize FTS results in a way that reduce FNR without imposing unnecessary anxious and extra money on most families. METHODS: The present investigation was conducted retrospectively on 197,210 pregnancies undergoing FTS for aneuploidies in Nilou medical laboratory, Tehran, Iran, from March 2015 to February 2016. RESULTS: Intermediate risk group is important as 23 out of 45 FN fell in the range 1:250 to 1:1100. By applying the proposed index, the ratio of fβ-hCG MoM to PAPP-A MoM and subsequent decision about NIPT, 8 out of 23 FN cases in intermediate group could be detected. CONCLUSION: Compared with the current policy, our novel proposed approach had better performance and could be applied by the Iran National Health Service to improve the screening program guideline.

Distribution of Biochemical and Ultrasound Markers Values in the First Trimester Screening Program in Timisoara

2017 ◽  
Vol 68 (7) ◽  
pp. 1636-1639
Author(s):  
Dan Navolan ◽  
Simona Vladareanu ◽  
Ioana Ciohat ◽  
Adrian Carabineanu ◽  
Marius Craina ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Pregnant Women ◽  
Biochemical Markers ◽  
Screening Program ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Ultrasound Measurement ◽  
First Trimester Screening ◽  
Disturbing Factor ◽  
Trimester Screening

The aim of our study was to analyze the distribution of biochemical markers (free-� hCG and PAPP-A) and nuchal translucency (NT) values and their deviation from expected median in our screening program. NT, free-� hCG and PAPP-A values were measured in first trimester sera of 1313 singleton pregnant women. The age (mean �standard deviation) of pregnant women at the time of screening was 28.94�4.95 years and the gestational age was 87.66�4.74 days. The value of NT (median�standard error of mean) was 0.87�0.01 multiple of median corrected (MoMc), of free-b hCG was 1.07�0.02 MoMc and of PAPP-A was 1.06�0.01 MoMc. Since the huge majority of pregnant women carried a healthy fetus it was assumed that the median value of measurements was equal to 1 MoMc and the deviation from median was equal to null. Our results showed that the greatest deviation from the expected median (-0.13 MoMc) was recorded for the NT measurement while the deviation for the free-� hCG and PAPP-A values was 0.07 respectively 0.06. In conclusion the main disturbing factor in calculating the aneuploidy risk was the measurement of NT. A systematic audit of laboratory and ultrasound measurement is necessary.

Can first-trimester screening program detect women at high risk for gestational diabetes mellitus?

2012 ◽  
Vol 29 (2) ◽  
pp. 137-140 ◽  
Author(s):  
Sevsen Kulaksizoglu ◽  
Mustafa Kulaksizoglu ◽  
Ayse Gul Kebapcilar ◽  
Ayse Nur Torun ◽  
Emel Ozcimen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
High Risk ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Screening Program ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening
Sign in / Sign up

Export Citation Format

Share Document