Immediate and long-term outcomes in children with prenatal diagnosis of selected isolated congenital heart defects

2007 ◽  
Vol 29 (1) ◽  
pp. 38-43 ◽  
Author(s):  
I. B. Fuchs ◽  
H. Müller ◽  
H. Abdul-Khaliq ◽  
T. Harder ◽  
J. W. Dudenhausen ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Long Term Outcomes

Long-term Neurodevelopmental Outcomes of Children with Congenital Heart Defects

2021 ◽  
Author(s):  
Neil Derridj ◽  
Romain Guedj ◽  
Johanna Calderon ◽  
Lucile Houyel ◽  
Nathalie Lelong ◽  
...  
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Neurodevelopmental Outcomes

Abstract 18284: Incidence of Epilepsy is Elevated in Children and Young Adults With Congenital Heart Defects Compared With the General Population: A Nationwide Cohort Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Morten Olsen ◽  
Bradley S Marino ◽  
Michelle Leisner ◽  
Jessica G Woo ◽  
Nicolas L Madsen
Keyword(s):  
Young Adults ◽  
Preterm Birth ◽  
General Population ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Birth Registry ◽  
Registration System ◽  
Children And Young Adults

Perioperative seizures related to surgery for congenital heart defects (CHD) are well described; however, few data exist on the long-term risk of epilepsy in patients with CHD. We aimed to estimate the incidence of epilepsy in children and young adults with CHD compared with the general population. Methods: Utilizing data from the Danish National Registry of Patients (DNRP) we identified all patients diagnosed with CHD before the age of 15 years between 1980 and 2010 who were born during the same period. The DNRP is a nationwide hospital discharge registry covering all Danish hospitals. Previously validated methodology using the DNRP was applied to measure the outcome, epilepsy, as well as presence of extra cardiac defects (ECD) and/or syndromes. We used the Danish Medical Birth Registry to identify preterm birth (gestational age<37 weeks). For each CHD subject, we identified 10 controls from the general population using the Danish Civil Registration System, matched by sex and birth year. A unique personal identifier assigned at birth and used in all Danish public registries enabled virtually complete follow up for migration, death, or epilepsy until January 1, 2013. We computed cumulative incidences and hazard ratios (HR) (split at 5 years of age to obtain proportional hazards) of time from CHD diagnosis (index date for controls) to epilepsy. Results: We identified 14,665 CHD subjects with a median age at diagnosis of 2 (IQR 19) months. By 15 years of age, the cumulative incidence of epilepsy was 4% among CHD subjects. The HR of epilepsy among CHD subjects compared with the control cohort was 3.7 (95% CI: 3.2-4.3) below 5 years of age, and 2.4 (95% CI: 2.1-2.7) from 5 to 33 years of age. In the older age group, HR for patients with severe CHD was 2.8 (95% CI: 2.3-3.5), and for mild and moderate CHD was 2.2 (95% CI: 1.8-2.6). After exclusion of all subjects with ECDs and/or syndromes and preterm birth, corresponding HRs were 2.2 (95% CI: 1.6-3.0) and 1.7 (95% CI: 1.3-2.2), respectively. Conclusion: The epilepsy risk was markedly increased in CHD subjects compared with the age and gender matched controls. These findings add evidence to support the importance of developing neuro-protective measures and potentially long-term epilepsy surveillance strategies in the CHD population.

Prenatal Diagnosis of Congenital Heart Defects in Thoracoabdominally Conjoined Twins

1985 ◽  
Vol 313 (6) ◽  
pp. 370-374 ◽  
Author(s):  
Stephen P. Sanders ◽  
Alvin J. Chin ◽  
Ira A. Parness ◽  
Beryl Benacerraf ◽  
Michael F. Greene ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Conjoined Twins

scholarly journals PRENATAL DIAGNOSIS OF CONGENITAL HEART DEFECTS: DOES IT MAKE A DIFFERENCE IN SURVIVAL?

2013 ◽  
Vol 61 (10) ◽  
pp. E476
Author(s):  
Matthew Oster ◽  
Christopher H. Kim ◽  
Aaron S. Kusano ◽  
Janet D. Cragan ◽  
Paul B. Dressler ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects

scholarly journals Prenatal diagnosis of congenital heart defects: accuracy and discrepancies in a multicenter cohort

2016 ◽  
Vol 47 (5) ◽  
pp. 616-622 ◽  
Author(s):  
C. L. van Velzen ◽  
S. A. Clur ◽  
M. E. B. Rijlaarsdam ◽  
E. Pajkrt ◽  
C. J. Bax ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Multicenter Cohort

Potential role of “omics” technique in prenatal diagnosis of congenital heart defects

2018 ◽  
Vol 482 ◽  
pp. 185-190
Author(s):  
Lizhu Chen ◽  
Johnny Guan ◽  
Qiuju Wei ◽  
Zhengwei Yuan ◽  
Mo Zhang
Keyword(s):  
Prenatal Diagnosis ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Potential Role ◽  
Heart Defects

scholarly journals Challenges in the Patient With Pulmonary Hypertension and Atrial Septal Defect: Understanding When and How to Close the Defect

2019 ◽  
Vol 18 (1) ◽  
pp. 10-13 ◽  
Author(s):  
Mary P. Mullen
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Arterial Hypertension ◽  
Congenital Heart ◽  
Septal Defect ◽  
Heart Defects ◽  
Defect Closure ◽  
Long Term Outcomes ◽  
Septal Defects ◽  
Pulmonary Arterial

Atrial septal defects (ASDs) are common congenital heart defects in children and adults. Pulmonary arterial hypertension (PAH) is found in subsets of both pediatric and adult patients with atrial defects under varied clinical contexts. The pulmonary hypertension specialist is often faced with questions surrounding timing and method of defect closure, which may have significant impact on procedural and long-term morbidity and survival. This review highlights important differences in management between children and adults with ASDs associated with PAH, highlighting indications for closure, operability, types of closure, and long-term outcomes.

scholarly journals Utility of Fetal Cardiovascular Magnetic Resonance for Prenatal Diagnosis of Complex Congenital Heart Defects

2021 ◽  
Vol 4 (3) ◽  
pp. e213538 ◽  
Author(s):  
Daniel Salehi ◽  
Katrin Fricke ◽  
Misha Bhat ◽  
Håkan Arheden ◽  
Petru Liuba ◽  
...  
Keyword(s):  
Cardiovascular Magnetic Resonance ◽  
Prenatal Diagnosis ◽  
Magnetic Resonance ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects
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