scholarly journals Reversible constriction of the fetal ductus arteriosus after maternal use of topical diclofenac and methyl salicylate

2006 ◽  
Vol 27 (2) ◽  
pp. 227-229 ◽  
Author(s):  
M. R. Torloni ◽  
E. Cordioli ◽  
M. M. Zamith ◽  
W. J. Hisaba ◽  
L. M. M. Nardozza ◽  
...  
Keyword(s):  
Methyl Salicylate ◽  
Ductus Arteriosus ◽  
Topical Diclofenac

scholarly journals Case Report: Persistent Pulmonary Hypertension of the Newborn and Narrowing of the Ductus Arteriosus After Topical Use of Non-Steroidal Anti-Inflammatory During Pregnancy

2021 ◽  
Vol 12 ◽  
Author(s):  
Kévin Le Duc ◽  
Sixtine Gilliot ◽  
Jean Benoit Baudelet ◽  
Sébastien Mur ◽  
Mohamed Riadh Boukhris ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricle ◽  
Ductus Arteriosus ◽  
Persistent Pulmonary Hypertension ◽  
Third Trimester ◽  
Case Presentation ◽  
The Third ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Topical Diclofenac

Background: The use of non-steroidal anti-inflammatory drugs (NSAIDs) during the third trimester of pregnancy can cause premature constriction of the ductus arteriosus. This report describes a case of in utero narrowing of the ductus arteriosus (DA) diagnosed postnatally in a baby with Persistent Pulmonary Hypertension of the Newborn (PPHN), after maternal use of Diclofenac-Epolamine 140 mg patch during the second and third trimester.Case Presentation: A fetal ultrasounds revealed an enlarged hypertrophic right ventricle at 32 weeks of gestation. Detailed questioning of the mother highlighted that topical Diclofenac (FLECTOR®) had been used at 26 and at 31 weeks of gestation. An echocardiography performed 8 h postnatally showed supra-systemic pulmonary hypertension, a restrictive ductus arteriosus and a dilated right ventricle. The newborn was treated by inhaled nitric oxide and oral Sildenafil and was discharged from hospital on day 24. He had a complete normalization of his pulmonary vascular resistance on day 48.Conclusion: This case illustrates the potential fetal and neonatal complications associated with maternal topical Diclofenac medication during pregnancy resulting in antenatal closure of the DA.

Die Rekrutierung von Thrombozyten im postnatalen Ductus arteriosus fördert einen adäquaten spontanen Verschluss

2010 ◽  
Vol 222 (S 01) ◽  
Author(s):  
K Echtler ◽  
K Stark ◽  
M Lorenz ◽  
M Schwaiger ◽  
O Genzel-Boroviczény ◽  
...  
Keyword(s):  
Ductus Arteriosus

Perkutan transluminale katheterinterventionelle Therapie angeborener Herzfehler

2009 ◽  
Vol 09 (03) ◽  
pp. 155-160
Author(s):  
F. T. Riede ◽  
I. Dähnert
Keyword(s):  
Ductus Arteriosus ◽  
Angeborener Herzfehler

ZusammenfassungPerkutane transluminale katheterinterventionelle Eingriffe spielen eine wichtige Rolle in der Behandlung angeborener Herzfehler und können herz- und gefäßchirurgische Eingriffe vorbereiten, ergänzen oder ersetzen. Das Spektrum möglicher Interventionen ist sehr breit. Als Standardtherapien im Kindesalter gelten heute der interventionelle Verschluss von Vorhofseptum-secundum-Defekten, des Ductus arteriosus und vaskulärer Gefäßfehlbildungen, die Ballonvalvuloplastie valvulärer Pulmonal- und Aortenstenosen sowie die Ballonangioplastie (mit oder ohne Stentimplantation) von peripheren Pulmonalarterien -stenosen und Reaortenisthmusstenosen. Für zahlreiche andere Herzfehler stehen Interventionen als Alternative zum herzchirurgischen Vorgehen zur Verfügung.

Sign in / Sign up

Export Citation Format

Share Document