scholarly journals OC048: First trimester screening for fetal anomalies using ultrasonography in an unselected population. Results from ?The Copenhagen First Trimester Study?

2003 ◽  
Vol 22 (S1) ◽  
pp. 13-14
Author(s):  
A. C. Shalmi ◽  
K. W�jdemann ◽  
K. Sundberg ◽  
V. Brocks ◽  
N. Gr�m ◽  
...  
Keyword(s):  
First Trimester ◽  
First Trimester Screening ◽  
Fetal Anomalies ◽  
Trimester Screening ◽  
Unselected Population

scholarly journals Patient-friendly integrated first trimester screening by NIPT and fetal anomaly scan

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Malgorzata Ilona Srebniak ◽  
Maarten F. C. M. Knapen ◽  
Marieke Joosten ◽  
Karin E. M. Diderich ◽  
Sander Galjaard ◽  
...  
Keyword(s):  
Genetic Counseling ◽  
Chromosomal Aberrations ◽  
Trisomy 21 ◽  
First Trimester ◽  
Maternal Blood ◽  
Fetal Anomaly ◽  
First Trimester Screening ◽  
Fetal Anomalies ◽  
Outpatient Visits ◽  
Trimester Screening

AbstractMany major structural fetal anomalies can be diagnosed by first trimester fetal anomaly scan. NIPT can accurately detect aneuploidies and large chromosomal aberrations in cfDNA in maternal blood plasma. This study shows how a patient-friendly first trimester screening for both chromosomal and structural fetal anomalies in only two outpatient visits can be provided. Genotype-first approach assures not only the earliest diagnosis of trisomy 21 (the most prevalent chromosome aberration), but also completion of the screening at 12–14 weeks. To ensure proper management and avoid unnecessary anxiety abnormal NIPT different from trisomy 21, 18 and 13 should be referred for genetic counseling.

Nearly half of all severe fetal anomalies can be detected by first-trimester screening in experts’ hands

2019 ◽  
Vol 47 (6) ◽  
pp. 619-624 ◽  
Author(s):  
Frank C.-K. Chen ◽  
Alexandra Bacovsky ◽  
Michael Entezami ◽  
Wolfgang Henrich
Keyword(s):  
Predictive Value ◽  
Early Stage ◽  
First Trimester ◽  
Fetal Anomaly ◽  
Fetal Malformation ◽  
First Trimester Screening ◽  
Fetal Anomalies ◽  
Predictive Values ◽  
Trimester Screening ◽  
A Prospective Study

Abstract Objective To evaluate the detection rate of severe fetal anomalies at the first-trimester screening (FTS) and, vice versa, to evaluate the follow-up of pathological results at FTS at the time of mid-trimester screening (MTS) and throughout pregnancy and delivery in a partially selected population of low-risk pregnancies. Methods We conducted a prospective study on the detection of severe fetal anomalies at routine FTS in 9891 pregnant women with 10,294 fetuses between 11 + 0 and 13 + 6 weeks of gestation. The findings of FTS were compared to the results of MTS and pregnancy and neonatal outcomes. Only cases with severe fetal anomalies were taken for statistical analysis in this study. Results There were 232 cases of fetal anomaly altogether. At the time of FTS, sonographic anomalies were diagnosed in 113 cases and further ultrasound controls arranged. In four cases, fetal anomaly was not confirmed by MTS; in the remaining 109 cases, the sonographic anomaly seen at FTS was confirmed at MTS and in the course of pregnancy with a resulting sensitivity for fetal malformation at FTS of 47.8%, a specificity of 99.96%, a positive predictive value of 96.5% and a negative predictive value of 98.8%. Conclusion FTS can detect almost half of all severe fetal anomalies at an early stage of pregnancy with positive predictive values of 90% and more. Sensitivities varied depending on the organ system and reached the highest figures for anomalies of the heart, the abdomen, the spine and the skeletal system.

scholarly journals Validation of a first-trimester screening model for pre-eclampsia in an unselected population

2017 ◽  
Vol 49 (2) ◽  
pp. 188-193 ◽  
Author(s):  
E. Scazzocchio ◽  
F. Crovetto ◽  
S. Triunfo ◽  
E. Gratacós ◽  
F. Figueras
Keyword(s):  
First Trimester ◽  
First Trimester Screening ◽  
Screening Model ◽  
Trimester Screening ◽  
Unselected Population
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