scholarly journals VP46.05: Differences in the first trimester vaginal microbiota associates with past obstetric history

2021 ◽  
Vol 58 (S1) ◽  
pp. 294-294
Author(s):  
H. Fourie ◽  
M. Al‐Memar ◽  
K. Grewal ◽  
S. Bobdiwala ◽  
S. Ng ◽  
...  
Keyword(s):  
First Trimester ◽  
Vaginal Microbiota ◽  
Obstetric History

scholarly journals The nasopharyngeal, ruminal, and vaginal microbiota and the core taxa shared across these microbiomes in virgin yearling heifers exposed to divergent in utero nutrition during their first trimester of gestation and in pregnant beef heifers in response to mineral supplementation

2021 ◽  
Author(s):  
Samat Amat ◽  
Devin B Holman ◽  
Kaycie Schmidt ◽  
Ana Clara B Menezes ◽  
Friederike Baumgaertner ◽  
...  
Keyword(s):  
Mixed Model ◽  
Linear Mixed Model ◽  
First Trimester ◽  
Nervous System Development ◽  
Vaginal Microbiota ◽  
Rrna Gene ◽  
Beef Heifers ◽  
Mineral Supplement ◽  
Alpha And Beta Diversity ◽  
Significant Difference

Emerging evidence has indicated that microbial transmission from the bovine dam to her fetus may take place before birth, and that the maternal microbiota during pregnancy modulates programming of fetal metabolic and nervous system development, highlighting the potential and extended role of the maternal microbiome in calf health and development. In the present study, we characterized the nasopharyngeal, ruminal and vaginal microbiota from two cohorts of beef heifers managed at the same location: 1) virgin yearling heifers (9 months old) born from dams received gestational diets which resulted in low (LG, n = 22) or medium (MG, n = 23) weight gain during the first 84 days of gestation; and 2) pregnant replacement heifers that received a vitamin and mineral supplement (VTM, n = 17) or not (Control, n = 15) during the first 6 months of gestation. Nasopharyngeal and vaginal swabs as well as ruminal fluid were collected from both cohorts and the microbiota of each sample was assessed using 16S rRNA gene sequencing. In addition to the comparison between treatment groups within each cohort, the similarity of the microbiota of the three sample types were evaluated, and shared taxa amongst these communities were identified. The bacterial genera present in the rumen and vagina that can influence methanogenic archaeal genera were predicted using a stepwise-selected generalized linear mixed model. No significant difference was observed in the alpha and beta diversity in any of the nasopharyngeal, ruminal and vaginal microbiota between LG and MG offspring virgin heifers, or between the control and VTM pregnant heifers (p > 0.05). Subtle compositional changes in the vaginal microbiota in yearling heifers, and in the nasopharyngeal and ruminal microbiota of pregnant heifers were detected in response to treatments. Forty-one archaeal and bacterial OTUs were shared by over 60% of all samples from both virgin and pregnant heifers. Two taxa within the Methanobrevibacter genus were identified as core taxa and this genus was more relatively abundant in pregnant heifers compared to virgin heifers. Among the 25 top genera, Prevotella and Prevotella UCG-003 (negative) and Christensenellaceae R-7 group (positive) were predicted to have a significant effect on ruminal Methanobrevibacter spp. The results of this study indicate that there is little impact of divergent gestational nutrition during the first trimester on the calf microbiome at 9 months postnatal, and that VTM supplementation during pregnancy may not alter the maternal microbiome. This study provides evidence that there are several microbial taxa, including methanogenic archaea, that are shared across the respiratory, gastrointestinal, and reproductive tracts, suggesting the need for a holistic evaluation of the bovine microbiota when considering potential maternal sources for seeding calves with pioneer microbiota.

scholarly journals Psychiatric Caseness and its Obstetric Correlates in Pregnant Population Attending Antenatal Clinic in TUTH

2015 ◽  
Vol 3 (2) ◽  
pp. 20-24 ◽  
Author(s):  
J Regmee ◽  
S P Ojha ◽  
M Chapagain ◽  
P Tulachan ◽  
N Ojha
Keyword(s):  
Psychiatric Illness ◽  
First Trimester ◽  
Antenatal Clinic ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Pregnant Females ◽  
Obstetric History ◽  
Social Settings ◽  
Health And Development

Background: Prevalence rates for psychiatric disorders during pregnancy have been found to range from 6-13%. Psychiatric caseness during pregnancy not only affects the mother but also affects the health and development of the child. Various factors have been found to be associated with psychiatric caseness in different cultural and social settings including obstetric history. Objective: To evaluate the relation of obstetric history in pregnant population with psychiatric caseness.Methods: This is a cross sectional study with a total of 300 sample collected within 6 months in antenatal clinic of obstetric OPD, TUTH using semi-structured proforma and SRQ-24. Results: 15% of the pregnant women could be labeled as psychiatric cases. Trimester and, complication during current pregnancy showed statistically significant association with psychiatric caseness. Conclusion: As 15% of pregnant ANC attendees were found to be having psychiatric illness, it can be recommended that pregnant females be routinely screened for the possibility of psychiatric caseness especially if it is the first trimester or complication during this pregnancy is noted.J Psychiatric Association of Nepal Vol .3, No.2, 2014, pp:20-24DOI: http://dx.doi.org/10.3126/jpan.v3i2.12383

scholarly journals The Nasopharyngeal, Ruminal, and Vaginal Microbiota and the Core Taxa Shared across These Microbiomes in Virgin Yearling Heifers Exposed to Divergent In Utero Nutrition during Their First Trimester of Gestation and in Pregnant Beef Heifers in Response to Mineral Supplementation

2021 ◽  
Vol 9 (10) ◽  
pp. 2011
Author(s):  
Samat Amat ◽  
Devin B. Holman ◽  
Kaycie Schmidt ◽  
Ana Clara B. Menezes ◽  
Friederike Baumgaertner ◽  
...  
Keyword(s):  
Reproductive Tract ◽  
Average Daily Gain ◽  
Methanogenic Archaea ◽  
16S Rrna Gene Sequencing ◽  
First Trimester ◽  
Vaginal Microbiota ◽  
Rrna Gene ◽  
Beef Heifers ◽  
Β Diversity ◽  
Significant Difference

In the present study, we evaluated whether the nasopharyngeal, ruminal, and vaginal microbiota would diverge (1) in virgin yearling beef heifers (9 months old) due to the maternal restricted gain during the first trimester of gestation; and (2) in pregnant beef heifers in response to the vitamin and mineral (VTM) supplementation during the first 6 months of pregnancy. As a secondary objective, using the microbiota data obtained from these two cohorts of beef heifers managed at the same location and sampled at the same time, we performed a holistic assessment of the microbial ecology residing within the respiratory, gastrointestinal, and reproductive tract of cattle. Our 16S rRNA gene sequencing results revealed that both α and β-diversity of the nasopharyngeal, ruminal and vaginal microbiota did not differ between virgin heifers raised from dams exposed to either a low gain (targeted average daily gain of 0.28 kg/d, n = 22) or a moderate gain treatment (0.79 kg/d, n = 23) during the first 84 days of gestation. Only in the vaginal microbiota were there relatively abundant genera that were affected by maternal rate of gain during early gestation. Whilst there was no significant difference in community structure and diversity in any of the three microbiota between pregnant heifers received no VTM (n = 15) and VTM supplemented (n = 17) diets, the VTM supplementation resulted in subtle compositional alterations in the nasopharyngeal and ruminal microbiota. Although the nasopharyngeal, ruminal, and vaginal microbiota were clearly distinct, a total of 41 OTUs, including methanogenic archaea, were identified as core taxa shared across the respiratory, gastrointestinal, and reproductive tracts of both virgin and pregnant heifers.

scholarly journals Two-year outcome after recurrent first trimester miscarriages: prognostic value of the past obstetric history

2016 ◽  
Vol 293 (5) ◽  
pp. 1113-1123 ◽  
Author(s):  
Christiane Kling ◽  
Julia Magez ◽  
Jürgen Hedderich ◽  
Sören von Otte ◽  
Dieter Kabelitz
Keyword(s):  
Prognostic Value ◽  
First Trimester ◽  
The Past ◽  
Obstetric History

Seroprevalence of rubella in antenatal women in and around Kirumampakkam, Puducherry

2012 ◽  
Vol 1 (10) ◽  
pp. 74
Author(s):  
Vinod Raveendran* ◽  
Dhandapany Senthil Pragash* ◽  
Dr. Manju ◽  
Ivvala Anand Shaker ◽  
Vijaya Rayapu
Keyword(s):  
First Trimester ◽  
Viral Disease ◽  
Childbearing Age ◽  
Immunization Policy ◽  
Rubella Infection ◽  
Igm Antibodies ◽  
Congenital Rubella ◽  
Obstetric History ◽  
Lower Socioeconomic ◽  
One Year

Rubella is a mild self limiting vaccine preventable viral disease. Maternal Rubella infection during first trimester of pregnancy leads to abortion, still birth and Congenital Rubella Syndrome. Seroepidemiological studies conducted in different countries have shown that Rubella is a worldwide infection. The present study was conducted to assess the immunity status to Rubella among pregnant women in and around Kirumampakkam, Puducherry for a period of one year. A detailed history with special reference for previous bad obstetric history was collected after an informed consent. They were tested for Rubella IgG and IgM antibodies using commercially available kits. Overall seropositivity was 87.9% and 12% were susceptible to Rubella infection. 6.5% were positive to Rubella specific IgM antibodies. Percentage of seropositivity was seen to be increasing with age. The percentage of IgG negatives was higher among the cases with bad obstetric history. Cases from lower socioeconomic status had good immunity against Rubella. All the cases that had previous immunization record were positive for Rubella specific IgG antibodies. In conclusion, an action revamping the national immunization policy should be considered along with sero-surveillance of Rubella among adolescent girls and women of childbearing age before conception for the assessment and analysis of the situation, and take appropriate action to eradicate Rubella.

scholarly journals Management and Outcomes of Pregnancy with Gestational Hypertension and Hyperthyroidism: A Case Report

2021 ◽  
pp. 295-299
Author(s):  
Arundhatee Dagadkar
Keyword(s):  
Thyroid Hormone ◽  
Caesarean Section ◽  
Physical Examination ◽  
Gestational Hypertension ◽  
Vital Signs ◽  
Fetal Monitoring ◽  
First Trimester ◽  
Therapeutic Interventions ◽  
Fluid Replacement ◽  
Obstetric History

Introduction: Hyperthyroidism associated increases in thyroid hormone concentrations have to be differentiated from physiological adjustments in thyroid hormone economic system that rise up all through being pregnant, especially in the first trimester. For one thousand births, one or two instances of gestational hyperthyroidism exist. It's critical to stumble on hyperthyroidism in a pregnant female due to the fact it is able to have harmful outcomes for each the mom and the infant. Presenting Complaint and Investigations: Patient’s chief complaints were vomiting, discomfort since 2 days. After physical examination and investigations, doctor diagnosed this as case of G2A1 with 35 weeks gestational age. This was a known case of gestational hypertension with hyperthyroidism. Investigations included Blood test, urine test, thyroid Profile, USG. Obstetric History: Patient had bad obstetric history. 2.5 months spontaneous abortion was reported. The Main Diagnoses, Therapeutic Interventions, and Outcomes: Gestational Hypertension with Known case of Hyperthyroidism. The patient had undergone various investigations like blood tests, USG, Physical examination. After physical examination and investigation doctor took a decision of emergency Lower segmental Caesarean section. Under spinal anaesthesia Lower segmental Caesarean section was done and outcome is good. Nursing Perspectives: Administered fluid replacement i.e. DNS and RL, Fetal monitoring, monitored all vital signs and observed the outcomes of treatment. Conclusion: Treatment and control of hypertension and hyperthyroidism in pregnancy at the right time increases the pregnancy's outcome.

scholarly journals Vaginal microbiota in the first trimester of pregnancy in women with a history of miscarriage

2018 ◽  
Vol 67 (5) ◽  
pp. 32-41
Author(s):  
Anna A. Sinyakova ◽  
Elena V. Shipitsyna ◽  
Olga V. Budilovskaya ◽  
Zinaida M. Martikaynen ◽  
Aleksey N. Grigoryev ◽  
...  
Keyword(s):  
Ph Value ◽  
First Trimester ◽  
Vaginal Flora ◽  
Vaginal Microbiota ◽  
Vaginal Fluid ◽  
Candida Spp ◽  
History Of ◽  
Group 2 ◽  
Aerobic Flora ◽  
Ureaplasma Spp

Hypothesis/aims of study. Dysbiotic disorders of the vagina are one of the main risk factors of miscarriage. The analysis of vaginal microbiota during pregnancy in women having a history of miscarriage may contribute to understanding the importance of specific types of vaginal flora in the development of processes resulting in spontaneous abortion or preterm birth. This study was undertaken to evaluate the vaginal flora in the 1st trimester of pregnancy in women having a history of miscarriage. Study design, materials, and methods. To participate in the study, 160 individuals in the 1st trimester of pregnancy with and without a history of miscarriage were invited. Group 1 included 100 women with a history of miscarriage, group 2 consisted of 60 women without a history of miscarriage. The vaginal flora was analyzed with microscopic, bacteriological, and quantitative real-time PCR methods. Results. In patients with a history of miscarriage, the frequency of dysbiotic disorders of the vaginal flora was three times higher (11.0% and 3.3%) and pH value of the vaginal fluid was significantly higher. Along with a significant reduction of the proportion of the Lactobacillus flora in the 1st trimester of pregnancy in patients having a history of miscarriage, there was a significant increase in the abundance of opportunistic microorganisms, mostly aerobic flora, such as Enterobacteriaceae, Streptococcus spp., and Staphylococcus spp. Furthermore, there was a significant predominance of Ureaplasma spp. and Candida spp. in women with a miscarriage history. Conclusion. The vaginal microbiota in the 1st trimester of pregnancy in women having a history of miscarriage is characterized by higher pH values of the vaginal fluid, the prevalence of opportunistic microorganisms, a decrease in the abundance of the Lactobacillus flora, and a higher concentration of aerobic bacteria, Ureaplasma spp., and Candida spp. These findings indicate dysbiotic disorders of the vaginal microbiocenosis in women having a history of miscarriage, which can lead to late miscarriage and pretem birth.

scholarly journals Vaginal Microbiota and Cytokine Levels Predict Preterm Delivery in Asian Women

2021 ◽  
Vol 11 ◽  
Author(s):  
Manoj Kumar ◽  
Selvasankar Murugesan ◽  
Parul Singh ◽  
Marwa Saadaoui ◽  
Duaa Ahmed Elhag ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Minority Groups ◽  
Neonatal Morbidity ◽  
First Trimester ◽  
Adverse Outcomes ◽  
Vaginal Microbiota ◽  
Asian Women ◽  
Vaginal Microbiome ◽  
High Resource ◽  
Cytokine Levels

Preterm birth (PTB) is the most common cause of neonatal morbidity and mortality worldwide. Approximately half of PTBs is linked with microbial etiologies, including pathologic changes to the vaginal microbiota, which vary according to ethnicity. Globally more than 50% of PTBs occur in Asia, but studies of the vaginal microbiome and its association with pregnancy outcomes in Asian women are lacking. This study aimed to longitudinally analyzed the vaginal microbiome and cytokine environment of 18 Karen and Burman pregnant women who delivered preterm and 36 matched controls delivering at full term. Using 16S ribosomal RNA gene sequencing we identified a predictive vaginal microbiota signature for PTB that was detectable as early as the first trimester of pregnancy, characterized by higher levels of Prevotella buccalis, and lower levels of Lactobacillus crispatus and Finegoldia, accompanied by decreased levels of cytokines including IFNγ, IL-4, and TNFα. Differences in the vaginal microbial diversity and local vaginal immune environment were associated with greater risk of preterm birth. Our findings highlight new opportunities to predict PTB in Asian women in low-resource settings who are at highest risk of adverse outcomes from unexpected PTB, as well as in Burman/Karen ethnic minority groups in high-resource regions.

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