scholarly journals VP16.03: First trimester thymus size and its correlation with five major chromosomal anomalies

2021 ◽  
Vol 58 (S1) ◽  
pp. 163-164
Author(s):  
M. Möllers ◽  
S. Kleemann ◽  
K. Oelmeier ◽  
H. Köster ◽  
J. Braun ◽  
...  
Keyword(s):  
First Trimester ◽  
Chromosomal Anomalies ◽  
Thymus Size

Correlation of first-trimester thymus size with chromosomal anomalies

2021 ◽  
Author(s):  
M Möllers ◽  
S Kleemann ◽  
J Braun ◽  
K Oelmeier ◽  
J Steinhard ◽  
...  
Keyword(s):  
First Trimester ◽  
Chromosomal Anomalies ◽  
Thymus Size

Correlation of first-trimester thymus size with chromosomal anomalies

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sarah Kleemann ◽  
Raphael Koch ◽  
Ralf Schmitz ◽  
Helen A. Köster ◽  
Janina Braun ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
First Trimester ◽  
Trisomy 18 ◽  
Trisomy 13 ◽  
Control Group ◽  
Chromosomal Anomalies ◽  
First Trimester Screening ◽  
Fetal Thymus ◽  
Trimester Screening ◽  
Thymus Size

Abstract Objectives The aim of this study was to investigate the correlation between fetal thymus size measured during first-trimester screening and chromosomal anomalies. Methods This study is a retrospective evaluation, in which the anterior-posterior diameter of the thymus in a midsagittal plane was measured in first-trimester ultrasound between 11+0 and 13+6 weeks of gestation in 168 fetuses with chromosomal anomalies (study group) and 593 healthy fetuses (control group). The included cases were subdivided into six groups: (1) trisomy 21, (2) trisomy 18, (3) trisomy 13, (4) Turner syndrome, (5) triploidy and (6) normal controls. Thymus size measurements were adjusted to the week of gestation, which was determined by ultrasound using crown-rump-length (CRL), by calculating a ratio between CRL and thymus size (CRL-thymus-ratio). Each study group was compared with the control group separately. Results Thymus size in fetuses affected by trisomy 18 or trisomy 13 was noticeably smaller compared to the control group (1.4 mm [1.3, 1.5] and 1.3 mm [1.2, 1.4] vs. 1.8 mm [1.6, 2.1]; all p<0.001; respectively). The thymus size of fetuses with trisomy 21 and Turner syndrome did not differ from healthy fetuses. Between the CRL-thymus-ratios of the separate study groups no statistically noticeable differences could be found. Conclusions Fetal thymus size appeared to be smaller in pregnancies affected by trisomy 18 and trisomy 13. The predictive value of fetal thymus size in first-trimester screening should be evaluated prospectively.

scholarly journals Unusual umbilical cord finding in a neonate

2019 ◽  
Vol 6 (6) ◽  
pp. 2685
Author(s):  
Antonieo Jude Raja ◽  
Sriambika K.
Keyword(s):  
Umbilical Cord ◽  
Congenital Anomalies ◽  
Cystic Lesion ◽  
Surgical Intervention ◽  
First Trimester ◽  
Chromosomal Anomalies ◽  
Umbilical Cord Cyst

Umbilical cord cyst refers to any cystic lesion that are associated with the umbilical cord. They are classified as true cysts or pseudocysts. True cysts are small remnants of the allantois, whereas false cysts originate from liquefaction of Wharton Jelly. In present case, cyst was diagnosed at birth without any associated congenital anomalies and resolved spontaneously within a few days requiring nil surgical intervention. Umbilical cord cysts deserve special attention since 20% of them, regardless of type, are associated with structural or chromosomal anomalies. Because of this, fetal karyotyping and amniocentesis should be considered when cysts persist beyond the first trimester.

Relationship between first trimester nuchal septations and chromosomal anomalies

2020 ◽  
Vol 60 (1) ◽  
pp. 1-4
Author(s):  
Qing Wang ◽  
Xin Wang ◽  
Qingqing Wu
Keyword(s):  
First Trimester ◽  
Chromosomal Anomalies

scholarly journals 464: Fetal tachycardia is an independent risk factor for chromosomal anomalies during first trimester genetic screening

2018 ◽  
Vol 218 (1) ◽  
pp. S279
Author(s):  
Andres Espinoza ◽  
Wesley Lee ◽  
Alireza A. Shamshirsaz ◽  
Michael A. Belfort ◽  
Jimmy Espinoza
Keyword(s):  
Risk Factor ◽  
Genetic Screening ◽  
Independent Risk Factor ◽  
First Trimester ◽  
Chromosomal Anomalies ◽  
Fetal Tachycardia

Ultrasound screening for chromosomal anomalies in the first trimester of pregnancy

1993 ◽  
Vol 13 (6) ◽  
pp. 513-518 ◽  
Author(s):  
Guido Savoldelli ◽  
Franz Binkert ◽  
Josef Achermann ◽  
Werner Schmid
Keyword(s):  
First Trimester ◽  
Chromosomal Anomalies ◽  
Ultrasound Screening ◽  
First Trimester Of Pregnancy

scholarly journals P10.10: First trimester screening for chromosomal anomalies II-nasal bone and ductus venosus (pilot study)

2004 ◽  
Vol 24 (3) ◽  
pp. 323-323
Author(s):  
L. Lopes ◽  
R. A. M. Sá ◽  
M. B. Silva ◽  
P. Nassar ◽  
P. C. Gomes ◽  
...  
Keyword(s):  
Pilot Study ◽  
Nasal Bone ◽  
First Trimester ◽  
Ductus Venosus ◽  
Chromosomal Anomalies ◽  
First Trimester Screening ◽  
Trimester Screening
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