scholarly journals P07.10: Asymptomatic postmenopausal women with endometrial polyps removed by hysteroscopy: prevalence of atypical hyperplasia, and cancer in a multicentre Italian study

2005 ◽  
Vol 26 (4) ◽  
pp. 425-425
Author(s):  
E. Ferrazzi ◽  
F. P. G. Leone ◽  
E. Zupi ◽  
M. Barbieri ◽  
M. Busacca ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Atypical Hyperplasia ◽  
Endometrial Polyps ◽  
Italian Study

Endometrial polyps in postmenopausal women: results of a comparative analysis of clinical features after hysteroscopic polypectomy

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (3) ◽  
pp. 55-58
Author(s):  
Tatiana V. Klinyshkova ◽  
Natalia B. Frolova ◽  
Elena A. Tsertsanova ◽  
Iuliia Iu. Saponenko
Keyword(s):  
Comparative Analysis ◽  
Postmenopausal Women ◽  
Clinical Features ◽  
Uterine Bleeding ◽  
Atypical Hyperplasia ◽  
Tamoxifen Treatment ◽  
Endometrial Polyps ◽  
Group 2 ◽  
Benign Course ◽  
Group 1

Aim. To evaluate the clinical features of endometrial polyps (EP) in postmenopausal patients based on a comparative analysis of symptomatic and asymptomatic forms. Мaterials and methods. A retrospective cohort study was conducted with the inclusion of 92 postmenopausal women who underwent hysteroscopic polypectomy in the gynecological Department of the Clinical Hospital of Russian Railways-Medicine Omsk in 20182019. Тhe аverage age of patients was 60.356.56 years. Two groups of patients were identified: group 1 included patients with asymptomatic EP (n=64), group 2 women with EP associated with uterine bleeding (n=28). Results. Postmenopausal EP patients had: asymptomatic (69.6%), uterine bleeding (30.4%), recurrent EP (14.3%), concomitant tamoxifen treatment (5.4%), single (77.2%) and multiple (22.8%) EP. In group 1, patients with late postmenopausal stage (73.4%) with single EP (76.6%) of various localization, glandular-fibrotic type (78.1%, p0.05) prevailed. Group 2 was dominated by patients with early postmenopausal stage (60.7%, p0.05) with single EP (78.6%, p0.05) of various localization, having glandular (50%, p0.01), glandular-fibrotic (46.4%, p0.01) EP and adenomatous EP with malignancy (3.57%, p0.05). Hyperplasia of endometrium was observed in both groups (1.56 and 3.57% in group 1 and 2, respectively), and adenocarcinoma in group 1 (1.56%). Conclusion. In patients with postmenopausal EP, along with a benign course, the disease occurs against the background of atypical hyperplasia and endometrial cancer (in the polyp or endometrium) in 3,3% of cases, including the asymptomatic nature of the disease.

scholarly journals Deep learning model for classifying endometrial lesions

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
YunZheng Zhang ◽  
ZiHao Wang ◽  
Jin Zhang ◽  
CuiCui Wang ◽  
YuShan Wang ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Endometrial Hyperplasia ◽  
Histogram Equalization ◽  
Atypical Hyperplasia ◽  
Endometrial Polyps ◽  
Submucous Myoma ◽  
Objective Model ◽  
Medical University ◽  
Deep Learning Model ◽  
Better Than

Abstract Background Hysteroscopy is a commonly used technique for diagnosing endometrial lesions. It is essential to develop an objective model to aid clinicians in lesion diagnosis, as each type of lesion has a distinct treatment, and judgments of hysteroscopists are relatively subjective. This study constructs a convolutional neural network model that can automatically classify endometrial lesions using hysteroscopic images as input. Methods All histopathologically confirmed endometrial lesion images were obtained from the Shengjing Hospital of China Medical University, including endometrial hyperplasia without atypia, atypical hyperplasia, endometrial cancer, endometrial polyps, and submucous myomas. The study included 1851 images from 454 patients. After the images were preprocessed (histogram equalization, addition of noise, rotations, and flips), a training set of 6478 images was input into a tuned VGGNet-16 model; 250 images were used as the test set to evaluate the model’s performance. Thereafter, we compared the model’s results with the diagnosis of gynecologists. Results The overall accuracy of the VGGNet-16 model in classifying endometrial lesions is 80.8%. Its sensitivity to endometrial hyperplasia without atypia, atypical hyperplasia, endometrial cancer, endometrial polyp, and submucous myoma is 84.0%, 68.0%, 78.0%, 94.0%, and 80.0%, respectively; for these diagnoses, the model’s specificity is 92.5%, 95.5%, 96.5%, 95.0%, and 96.5%, respectively. When classifying lesions as benign or as premalignant/malignant, the VGGNet-16 model’s accuracy, sensitivity, and specificity are 90.8%, 83.0%, and 96.0%, respectively. The diagnostic performance of the VGGNet-16 model is slightly better than that of the three gynecologists in both classification tasks. With the aid of the model, the overall accuracy of the diagnosis of endometrial lesions by gynecologists can be improved. Conclusions The VGGNet-16 model performs well in classifying endometrial lesions from hysteroscopic images and can provide objective diagnostic evidence for hysteroscopists.

scholarly journals Prevalence and characteristics of endometrial polyps in patients with abnormal uterine bleeding

2008 ◽  
Vol 65 (5) ◽  
pp. 349-352 ◽  
Author(s):  
Biljana Djordjevic ◽  
Jelena Milosevic ◽  
Zorica Stanojevic
Keyword(s):  
Endometrial Carcinoma ◽  
Statistical Significance ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Atypical Hyperplasia ◽  
Endometrial Polyps ◽  
Female Population ◽  
Group A ◽  
Malignant Changes ◽  
Group B

Background/Aim. The prevalence of endometrial polyps (EPs) in the general female population is about 24%. Abnormal uterine bleeding is frequently the presenting symptom of EPs. The aim of this study was to determine the prevalence and characteristics of EPs in patients with abnormal uterine bleeding. Methods. The prevalence and characteristics of EPs were investigated in 961 patients with abnormal uterine bleeding who underwent dilatation and curettage between January and December 2006. Regarding histopathological features of EPs (presence of atypical hyperplasia or endometrial carcinoma), patients were divided into two groups: group A - patients who had EPs and EPs with hyperplasia without atypia (n = 204) and group B - patients who had EPs with atypical hyperplasia and EPs with carcinoma (n = 7). Results. In 211 (21.94%) patients EPs were found with abnormal uterine bleeding. Histopathologically, there were 175 (82.94%) EPs, 29 (13.74%) EPs with hyperplasia without atypia, 5 (2.37%) EPs with atypical hyperplasia, and 2 (0.95%) EPs with endometrial carcinoma. Contrary to the patients with EPs and EPs with hyperplasia without atypia (group A), patients who had EPs with atypical hyperplasia and EPs with carcinoma (group B) were older (p < 0.05), and more commonly postmenopausal (p < 0.05) and with hypertension (p < 0.05), all of statistical significance. Conclusion. The prevalence of endometrial polyps in patients with abnormal uterine bleeding according to our data was 21.95%. Atypical hyperplasia and endometrial carcinoma were rarely confined to a polyp. Older age, postmenopausal period and hypertension may increase the risk of premalignant and malignant changes in endometrial polyps.

scholarly journals Endometrial polyps: Pathogenesis, sequelae and treatment

2019 ◽  
Vol 7 ◽  
pp. 205031211984824 ◽  
Author(s):  
Njume Peter Nijkang ◽  
Lyndal Anderson ◽  
Robert Markham ◽  
Frank Manconi
Keyword(s):  
Postmenopausal Women ◽  
Uterine Cavity ◽  
Reproductive Age ◽  
Endometrial Polyps ◽  
Asymptomatic Women

Endometrial polyps are overgrowths of endometrial glands that typically protrude into the uterine cavity. Endometrial polyps are benign in nature and affect both reproductive age and postmenopausal women. Although endometrial polyps are relatively common and may be accompanied by abnormally heavy bleeding at menstruation. In asymptomatic women, endometrial polyps may regress spontaneously, in symptomatic women endometrial polyps can be treated safely and efficiently with hysteroscopic excision.

scholarly journals Proliferation in Postmenopausal Endometrial Polyps—A Potential for Malignant Transformation

Medicina ◽  
2019 ◽  
Vol 55 (9) ◽  
pp. 543 ◽  
Author(s):  
Adomaitienė ◽  
Nadišauskienė ◽  
Nickkho-Amiry ◽  
Čižauskas ◽  
Palubinskienė ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Postmenopausal Women ◽  
Malignant Transformation ◽  
Hot Spot ◽  
Control Group ◽  
Ki 67 ◽  
Endometrial Polyps ◽  
Significant Difference ◽  
Immunohistochemical Studies ◽  
Asymptomatic Women

Background and objectives: Endometrial polyps in asymptomatic postmenopausal women are often incidentally found, yet only 1.51% of them are malignant. Their potential for malignant transformation has not been adequately addressed. The aim of this study was to investigate the proliferation within endometrial polyps as one of the indicators of their malignization potential in asymptomatic postmenopausal women. Materials and Methods: Immunohistochemical studies of Ki-67 were performed. Cases included 52 benign postmenopausal polyps, 19 endometrioid carcinoma with coexisting benign polyps, 12 polyps with foci of carcinoma and 4 cases of polyps, which later developed carcinoma. The control group included 31 atrophic endometria and 32 benign premenopausal polyps. Ki-67 was scored in either 10 or 20 “hot spot” fields, as percentage of positively stained cells. Results: The median epithelial Ki-67 score in postmenopausal benign polyps (4.7%) was significantly higher than in atrophic endometria (2.41%, p < 0.0001) and significantly lower than in premenopausal benign polyps (11.4%, p = 0.003) and endometrial cancer (8.3%, p < 0.0001). Where endometrial polyps were found in association with endometrial carcinoma, Ki-67 was significantly higher in cancer (p < 0.0001). No significant difference was found between Ki-67 scores of cancer focus and of the polyps tissue itself, respectively 2.8% and 4.55%, p = 0.37. Ki-67 expression, where polyps were resected and women later developed cancer, was not significantly different (p = 0.199). Conclusion: Polyps from asymptomatic postmenopausal women showed significantly more proliferation in both epithelial and stromal components than inactive atrophic endometria but less than premenopausal benign polyps and/or endometrial cancer. Benign postmenopausal endometrial polyps exhibit low proliferative activity, suggesting low malignant potential and may not require resection in asymptomatic women.

Endometrial Calcifications

2020 ◽  
Vol 28 (6) ◽  
pp. 590-599
Author(s):  
Badr AbdullGaffar ◽  
Amal AlMulla
Keyword(s):  
Postmenopausal Women ◽  
Ciliated Cell ◽  
Clinical Importance ◽  
Endometrial Polyps ◽  
Oral Contraceptive Pills ◽  
Younger Women ◽  
Contraceptive Pills ◽  
Placental Site ◽  
Size And Morphology ◽  
Placental Site Nodule

Benign endometrial calcifications with or without bone fragments are uncommon clinicopathologic findings. They can be detected during pelvic ultrasonography or as incidental pathologic findings. They have been found to be associated with infertility and menstrual anomalies in young adult patients and in symptomatic postmenopausal women with endometrial atrophy and endometrial polyps. Its exact etiology is unknown, its pathogenesis is controversial, and its clinical importance is not fully validated. We performed a retrospective review study over 7 years and found 11 (0.4%) cases of benign endometrial calcifications. The mean patient age was 45.2 years (range = 20-66 years). All of the women complained of menstrual abnormalities and 4 complained of infertility. Six had a previous procedure of abortion, 2 had oral contraceptive pills, and 4 a course of progesterone therapy. Their size and morphology varied from heterogeneous microcalcifications of variable appearances, shattered glassy chunks to detached bones. Four cases were associated with endometrial polyps, 1 with a placental site nodule, 1 with chronic endometritis, and 1 with endometrial hyperplasia. Most showed secretory endometrial tissue and ciliated cell metaplasia. Two cases showed atrophic endometrium. Etiology and pathogenesis are multifactorial and miscellaneous. Progesterone may play a role. Heterogeneous histomorphologic patterns may carry potential pitfalls. Pathologic recognition is clinically important to reassure clinicians in symptomatic postmenopausal women, alert gynecologists to a treatable albeit rare cause of infertility in younger women, and assist in patients’ counselling. We also included cases of calcifications associated with endometrial malignancies to compare and contrast malignant endometrial calcifications with benign endometrial calcifications.

Is hysteroscopic appearance a safe means of differentiating malignant from benign endometrial polyps in postmenopausal women?

2001 ◽  
Vol 10 (1) ◽  
pp. 49-51 ◽  
Author(s):  
Patricia de Almeida ◽  
Silva Reis ◽  
Antonio A. Nogueira ◽  
Francisco J. C. dos Reis ◽  
Adriana Campolungo ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Endometrial Polyps
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