scholarly journals VP03.03: Correlation between sonographic findings with histopathological and molecular characteristics in invasive breast carcinoma

2021 ◽  
Vol 58 (S1) ◽  
pp. 100-100
Author(s):  
A. Kammoun ◽  
F. Affes ◽  
H. Frikha ◽  
I. Karray ◽  
A. Karoui ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Invasive Breast Carcinoma ◽  
Molecular Characteristics

scholarly journals Genetic Alterations in Invasive Breast Carcinoma with a Glycogen-Rich Clear Cell Pattern: A Case Report

2021 ◽  
pp. 500-505
Author(s):  
Carlo De la Sancha ◽  
Roberto Ruiz-Cordero ◽  
Nikolay Popnikolov
Keyword(s):  
Breast Carcinoma ◽  
Molecular Mechanisms ◽  
Clear Cell ◽  
Checkpoint Inhibitors ◽  
Genetic Alterations ◽  
Invasive Breast Carcinoma ◽  
Molecular Characteristics ◽  
Dna Breaks ◽  
Cell Pattern ◽  
Truncating Mutation

Invasive carcinoma with a glycogen-rich clear cell pattern (IC-GRCCP) is a rare and understudied subtype of invasive breast carcinoma of no special type (IBC-NST). Here we report the molecular characteristics of a mammary IC-GRCCP diagnosed in a 69-year-old woman. Next-generation sequencing of the tumor revealed an inv(1)(p36.12,q32.1) leading to loss-of-function of ARID1A gene, a MAP2K4 truncating mutation (p.E376), MYC amplification, a variant of uncertain significance of PTPRB gene (p.D1848N) and deep deletions of NCKAP5, CCNT2, MAP3K19, LRP1B, and KMT2A. The analysis of the involved pathways shows close resemblance to the ovarian clear cell carcinoma and indicates similarities in the molecular mechanisms of development of glycogen-rich clear cell carcinomas in different organs. Our findings and the literature review suggest new potential strategies for treatment of mammary IC-GRCCP, including epigenetic therapies, checkpoint inhibitors, radiation, or other double-strand DNA breaks-inducing agents. Nevertheless, larger studies are needed to substantiate those ideas.

A case of pituitary metastasis in female patient with an invasive breast carcinoma

2018 ◽  
Author(s):  
Emna Elfaleh ◽  
Ibtissem Oueslati ◽  
Melika Chihaoui ◽  
Meriem Yazidi ◽  
Fatma Chaker ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Female Patient ◽  
Invasive Breast Carcinoma ◽  
Pituitary Metastasis

Validation of a Novel Nomogram for the Prediction of Local Relapse after Surgery for Invasive Breast Carcinoma

2019 ◽  
Author(s):  
Giovanni Corso ◽  
Patrick Maisonneuve ◽  
Giulia Massari ◽  
Alessandra Invento ◽  
Gabriella Pravettoni ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Local Relapse ◽  
Invasive Breast Carcinoma

scholarly journals DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Guillaume B. Cardin ◽  
Monique Bernard ◽  
Francis Rodier ◽  
Apostolos Christopoulos
Keyword(s):  
Breast Carcinoma ◽  
Signaling Pathway ◽  
Prognostic Value ◽  
Colorectal Adenocarcinoma ◽  
Prostate Adenocarcinoma ◽  
Small Cell ◽  
Invasive Breast Carcinoma ◽  
Integrin Signaling ◽  
Small Cell Lung ◽  
And Function

AbstractGermline single nucleotide polymorphisms in the promoter region of the DCBLD1 gene are associated with non-smoking cases of both non-small cell lung carcinoma (NSCLC) and human papillomavirus-negative head and neck cancer. However the clinical relevance and function of DCBLD1 remain unclear. This multicenter retrospective study was designed to evaluate the prognostic value and function of DCBLD1 in the four main solid cancers: NSCLC, invasive breast carcinoma, colorectal adenocarcinoma and prostate adenocarcinoma. We included the following cohorts: GSE81089 NSCLC, METABRIC invasive breast carcinoma, GSE14333 colorectal adenocarcinoma, GSE70770 prostate adenocarcinoma and The Cancer Genome Atlas (TCGA) Firehose Legacy cohorts of all four cancers. DCBLD1 gene expression was associated with a worse overall survival in multivariate analyses for both NSCLC cohorts (TCGA: P = 0.03 and GSE81089: P = 0.04) and both invasive breast carcinoma cohorts (TCGA: P = 0.02 and METABRIC: P < 0.001). Patients with high DCBLD1 expression showed an upregulation of the integrin signaling pathway in comparison to those with low DCBLD1 expression in the TCGA NSCLC cohort (FDR = 5.16 × 10–14) and TCGA invasive breast carcinoma cohort (FDR = 1.94 × 10–05).

The value of tumor-infiltrating lymphocytes and CD8 expression as a predictor of response to anthracycline-based neoadjuvant chemotherapy in invasive breast carcinoma of no special type

2021 ◽  
pp. 1-6
Author(s):  
Upik A. Miskad ◽  
Rizki A. Rifai ◽  
Rina Masadah ◽  
Berti Nelwan ◽  
Djumadi Ahmad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Immune System ◽  
Breast Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Predictive Value ◽  
Disease Free Survival ◽  
Tumor Infiltrating Lymphocytes ◽  
Invasive Breast Carcinoma ◽  
Study Results ◽  
Infiltrating Lymphocytes

BACKGROUND: The immune system is known to play an important role in tumor cell eradication. Although cancer cells were able to escape from the immune system, many studies showed mononuclear inflammatory cell infiltrates known as tumor-infiltrating lymphocytes (TILs) on breast cancer histopathology specimens showed better prognosis, including in disease-free survival (DFS) and chemotherapy responses. OBJECTIVE: This study aimed to reveal the predictive value of tumor-infiltrating lymphocytes (TILs) levels and CD8 expression in invasive breast carcinoma of no special type patients’ samples on response to anthracycline-based neoadjuvant chemotherapy. METHODS: 75 pre-treatment biopsy samples that were diagnosed as invasive breast carcinoma of no special type were evaluated. TILs level determined following recommendations of International TILs Working Group 2014, CD8 expression assessed semiquantitatively after immunohistochemistry staining. Response to anthracycline-based neoadjuvant chemotherapy evaluated clinically using Response Evaluation Criteria in Solid Tumours (RECIST) criteria and pathologically by evaluating hematoxylin and eosin (H&E)-stained slides from mastectomy specimens after 3 or 4 cycles of neoadjuvant chemotherapy. RESULTS: Chi-squared analysis showed a significant relationship between TILs level and CD8 expression with chemotherapy responses clinically (p = 0.011 and p = 0.017 respectively) but not pathologically. Furthermore, the logistic regression test exhibit the predictive value of TILs level was 66.7% and CD8 expression was 64%. CONCLUSIONS: This study results suggest that TILs level and CD8 expression may be added as predictive factors to the response of anthracycline-based neoadjuvant chemotherapy, and oncologists may take benefit in breast cancer patient’s management.

Power Doppler breast ultrasound: association of vascularization and ER/c-erbB-2 co-expression in invasive breast carcinoma

Breast Cancer ◽  
2011 ◽  
Vol 20 (2) ◽  
pp. 152-158 ◽  
Author(s):  
Shou-Tung Chen ◽  
Shou-Jen Kuo ◽  
Hwa-Koon Wu ◽  
Li-Sheng Chen ◽  
Dar-Ren Chen
Keyword(s):  
Breast Carcinoma ◽  
Power Doppler ◽  
Breast Ultrasound ◽  
Invasive Breast Carcinoma

Tenascin Staining Positivity and the Survival of Patients with Invasive Breast Carcinoma

1993 ◽  
Vol 55 (3) ◽  
pp. 295-297 ◽  
Author(s):  
Tetsuji Shoji ◽  
Tomoo Kamiya ◽  
Airo Tsubura ◽  
Yoshinori Hamada ◽  
Takehiko Hatano ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Invasive Breast Carcinoma
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