scholarly journals OP05.02: Added value of diffusion tensor imaging in evaluation of right ventricle function in fetal hypoplastic left heart syndrome

2021 ◽  
Vol 58 (S1) ◽  
pp. 73-73
Author(s):  
J. Ma ◽  
H. Cao ◽  
L. Hong ◽  
L. Zhang ◽  
M. Xie
Keyword(s):  
Diffusion Tensor Imaging ◽  
Right Ventricle ◽  
Hypoplastic Left Heart Syndrome ◽  
Diffusion Tensor ◽  
Added Value ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Right Ventricle Function ◽  
Left Heart Syndrome ◽  
Ventricle Function

Pathological changes and myocardial remodelling related to the mode of shunting following surgical palliation for hypoplastic left heart syndrome

2008 ◽  
Vol 18 (4) ◽  
pp. 415-422 ◽  
Author(s):  
Massimo A. Padalino ◽  
Chiara Castellani ◽  
Silvia Toffoli ◽  
Mila Della Barbera ◽  
Ornella Milanesi ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Right Ventricle ◽  
Hypoplastic Left Heart Syndrome ◽  
Pulmonary Arteries ◽  
Left Heart ◽  
Pulmonary Shunt ◽  
Hypoplastic Left Heart ◽  
Surgical Palliation ◽  
The Right ◽  
Left Heart Syndrome

AbstractBackgroundThe modification of placing the shunt from the right ventricle to the pulmonary arteries, also known as Sano procedure, has allegedly improved results over the short term in surgical palliation of hypoplastic left heart syndrome with the Norwood procedure. With this in mind, we reviewed autopsied specimens from neonates and children who did not survive after either a classic arterio-pulmonary shunt, or the modified procedure with the shunt placed from the right ventricle to the pulmonary arteries, so as to evaluate the pathological substrates of the remodelling of the systemic right ventricle, assessing any differences induced by the 2 techniques.MethodsWe obtained the hearts from 11 patients with neonatal diagnosis of hypoplastic left heart syndrome who died after the first or second stages of the Norwood sequence of operations, comparing them with 6 normal hearts matched for age and weight. Macroscopic, microscopic and morphometric analysis were performed on each specimen, evaluating the diameter of the myocytes, extracellular matrix remodelling in terms of fibrosis and type of collagen, and vascularization in terms of capillary density.ResultsHypertrophy of the myocytes was significantly increased in the hearts from patients having either a classic arterio-pulmonary or the ventriculo-pulmonary modification of the shunt compared to controls (p < 0.05). Myocardial fibrosis was increased in those having a shunt placed from the right ventricle to the pulmonary arteries when compared to the other 2 groups. The ratio of collagen I to collagen III was similar in those undergoing a classic arterio-pulmonary shunt compared to controls (0.94), but was lower in those having a shunt placed from the right ventricle to the pulmonary arteries (0.61), with an increase in collagen type III. The density of capillaries was lower in those who had undergone a classic arterial shunt when compared to the others.ConclusionWe have shown greater remodelling of the ventricular myocardial extracellular matrix in patients having a shunt from the right ventricle to the pulmonary arteries when compared to those having a classic arterio-pulmonary shunt, with this remodelling progressing even after the neonatal period. This may influence a later suboptimal ventricular performance.

Right ventricle in hypoplastic left heart syndrome exhibits altered hemodynamics in the human fetus

2020 ◽  
Vol 112 ◽  
pp. 110035
Author(s):  
Banafsheh Zebhi ◽  
Hadi Wiputra ◽  
Lisa Howley ◽  
Bettina Cuneo ◽  
Dawn Park ◽  
...  
Keyword(s):  
Right Ventricle ◽  
Hypoplastic Left Heart Syndrome ◽  
Human Fetus ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Left Heart Syndrome

scholarly journals Interstage evaluation of homograft-valved right ventricle to pulmonary artery conduits for palliation of hypoplastic left heart syndrome

2018 ◽  
Vol 155 (4) ◽  
pp. 1747-1755.e1 ◽  
Author(s):  
Nefthi Sandeep ◽  
Rajesh Punn ◽  
Sowmya Balasubramanian ◽  
Shea N. Smith ◽  
Olaf Reinhartz ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Right Ventricle ◽  
Hypoplastic Left Heart Syndrome ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Left Heart Syndrome
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