scholarly journals OP03.06: Did severe acute respiratory syndrome COVID‐19 infection affect umbilical vein blood flow and fetal cardiac function?

2021 ◽  
Vol 58 (S1) ◽  
pp. 67-67
Author(s):  
G. Rizzo ◽  
I. Mappa ◽  
P. Maqina ◽  
R. Nale ◽  
A. Alessio ◽  
...  
2013 ◽  
Vol 118 (4) ◽  
pp. 796-808 ◽  
Author(s):  
Pornswan Ngamprasertwong ◽  
Erik C. Michelfelder ◽  
Shahriar Arbabi ◽  
Yun Suk Choi ◽  
Christopher Statile ◽  
...  

Abstract Background: Use of high-dose inhalational anesthesia during open fetal surgery may induce maternal–fetal hemodynamic instability and fetal myocardial depression. The authors’ preliminary human retrospective study demonstrated less fetal bradycardia and left ventricular systolic dysfunction with lower dose desflurane supplemented with propofol and remifentanil IV anesthesia (SIVA). In this animal study, the authors compare maternal–fetal effects of high-dose desflurane anesthesia (HD-DES) and SIVA. Methods: Of 26 instrumented midgestational ewes, data from 11 animals exposed to both SIVA and HD-DES in random sequences and six animals exposed to HD-DES while maternal normotension was maintained were analyzed. Maternal electroencephalography was used to guide comparable depths of anesthesia in both techniques. Hemodynamic parameters, blood gas, and fetal cardiac function from echocardiography were recorded. Results: Compared with SIVA, HD-DES resulted in significant maternal hypotension (mean arterial pressure difference, 19.53 mmHg; 95% CI, 17.6–21.4; P < 0.0001), fetal acidosis (pH 7.11 vs. 7.24 at 150 min, P < 0.001), and decreased uterine blood flow. In the HD-DES group with maternal normotension, uterine blood flow still declined and fetal acidosis persisted, with no statistically significant difference from the group exposed to HD-DES that had maternal hypotension. There was no statistically significant difference in fetal cardiac function. Conclusion: In sheep, SIVA affects maternal hemodynamics less and provides better fetal acid/base status than high-dose desflurane. Fetal echocardiography did not reflect myocardial dysfunction in this model.


2016 ◽  
Vol 26 (3) ◽  
pp. 141-145 ◽  
Author(s):  
Yılmaz YOZGAT ◽  
Muhittin Eftal AVCI ◽  
Rahmi ÖZDEMİR ◽  
Cem KARADENİZ ◽  
Mustafa DEMİROL ◽  
...  

Author(s):  
S.I. Buryakova, M.V. Medvedev

The article deals with the physiology of the heart and methods to assess fetal cardiac function. The leadingedge technique to assess the myocardial deformation properties by speckle tracking echocardiography in prenatal period is presented.


2015 ◽  
Vol 10 (9) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Jin-Won Lee ◽  
Nam-In Baek ◽  
Dae-Young Lee

This study was conducted to investigate the effects of the crude extract from Acanthopanax sessiliflorus fruits and the isolated seco-triterpenoids from the crude extract on blood flow in human umbilical vein endothelial cell (HUVEC) invasion assay and angiotensin converting enzyme (ACE) inhibitory activity assay. On the basis of DMSO, the extent of HUVECs'invasion was remarkably decreased with crude extract concentrations of 400 and 1000 μg/mL. Additionally, the extent of the HUVEC invasion inhibitory effect in 400 and 1000 μg/mL of acanthosessilioside F were 55.8% and 72.4%, respectively. In addition, the maximum extent of the HUVEC invasion inhibitory effect of 22-α-hydroxychiisanoside was 88.9%. The IC50 value of the inhibitory effect on ACE activity in the crude extract was 4 μg/mL. The isolated seco-triterpenoids, 22α-hydroxychiisanogenin, 3,4- seco-lupan-20(30)-en-3,28-dioic acid, (1 R)-1,4-epoxy-11α,22α-hydroxy-3,4- seco-lupan-20(30)-en-3,28-dioicacid, (+)-divaroside, and chiisanosidehad showed very high inhibitory effects on ACE activity, ranging from 1.8 to 2.9 üg/mL, which is much higher than the 150.0 üg/mL effect of aspirin. These results suggest that the crude extract from Acanthopanax sessiliflorus fruits and the isolated seco-triterpenoids from the crude extract enhance the blood flow effect by decreasing ACE activity.


Author(s):  
Miroslava Svobodova ◽  
Elena S. Di Martino

The heart is a very efficient mechanical pump whose function is to controls the blood flow in the body. Two physical systems, namely mechanical for the pumping action and electrical for the control interact within the heart. Cardiac function can only be studied if both mechanical and electrical systems are considered. In particular, we are interested in the electromechanical control of the atrium pump function which is less studied then the electromechanical control of the ventricle pump function and none the less is a crucial factor in the development of atrial fibrillation.


2010 ◽  
Vol 35 (1) ◽  
pp. 19-27 ◽  
Author(s):  
J. J. Stirnemann ◽  
M. Mougeot ◽  
F. Proulx ◽  
B. Nasr ◽  
M. Essaoui ◽  
...  

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