scholarly journals OC06.08: *The assessment of microRNA as a novel biomarker in pregnancy of unknown location outcome prediction and ectopic pregnancy diagnosis

2021 ◽  
Vol 58 (S1) ◽  
pp. 20-21
Author(s):  
C. Kyriacou ◽  
S. Kim ◽  
M. Arianoglou ◽  
S. Bobdiwala ◽  
J. Barcroft ◽  
...  
Keyword(s):  
Ectopic Pregnancy ◽  
Outcome Prediction ◽  
Pregnancy Diagnosis ◽  
Pregnancy Of Unknown Location ◽  
In Pregnancy

scholarly journals OC06.01: Point‐of‐care testing in pregnancy of unknown location outcome prediction

2021 ◽  
Vol 58 (S1) ◽  
pp. 18-18
Author(s):  
C. Kyriacou ◽  
S. Kapur ◽  
S. Jeyapala ◽  
S. Bobdiwala ◽  
H. Fourie ◽  
...  
Keyword(s):  
Outcome Prediction ◽  
Point Of Care ◽  
Point Of Care Testing ◽  
Pregnancy Of Unknown Location ◽  
In Pregnancy

scholarly journals Factors to consider in pregnancy of unknown location

2017 ◽  
Vol 13 (2) ◽  
pp. 27-33 ◽  
Author(s):  
Shabnam Bobdiwala ◽  
Maya Al-Memar ◽  
Jessica Farren ◽  
Tom Bourne
Keyword(s):  
Clinical Practice ◽  
High Risk ◽  
Ectopic Pregnancy ◽  
Management Strategies ◽  
Evidence Base ◽  
Final Outcome ◽  
Everyday Clinical Practice ◽  
Pregnancy Of Unknown Location ◽  
In Pregnancy

The management of women with a pregnancy of unknown location (PUL) can vary significantly and often lacks a clear evidence base. Intensive follow-up is usually required for women with a final outcome of an ectopic pregnancy. This, however, only accounts for a small proportion of women with a pregnancy of unknown PUL location. There remains a clear clinical need to rationalize the follow-up of PUL so women at high risk of having a final outcome of an ectopic pregnancy are followed up more intensively and those PUL at low risk of having an ectopic pregnancy have their follow-up streamlined. This review covers the main management strategies published in the current literature and aims to give clinicians an overview of the most up-to-date evidence that they can take away into their everyday clinical practice when caring for women with a PUL.

Role of Serum β-HCG doubling in Diagnosis of Early Pregnancy and its Management Strategy

2020 ◽  
Vol 16 ◽  
Author(s):  
Divya Mirji ◽  
Shubha Rao ◽  
Akhila Vasudeva ◽  
Roopa P.S
Keyword(s):  
Ectopic Pregnancy ◽  
Early Pregnancy ◽  
Management Strategy ◽  
Transvaginal Ultrasound ◽  
Expectant Management ◽  
First Trimester ◽  
Intrauterine Pregnancy ◽  
Β Hcg ◽  
Pregnancy Of Unknown Location

Background: Pregnancy of unknown location (PUL) is defined as the absence of intrauterine or extrauterine sac and Beta Human Chorionic Gonadotropin levels (β-HCG) above the discriminatory zone of 1500 mIU/ml. It should be noted that PUL is not always an ectopic; however, by measuring the trends of serum β-HCG, we can determine the outcome of a PUL. Objective: This study aims to identify the various trends β-HCG levels in early pregnancy and evaluate the role of β-HCG in the management strategy. Methods: We conducted a prospective observational study of pregnant women suspected with early pregnancy. Cases were classified as having a pregnancy of unknown location (PUL) by transvaginal ultrasound and ß-HCG greater than 1000 mIU/ml. Expectant management was done until there was a definite outcome. All the collected data were analyzed by employing the chi-square test using SPSS version 20. Results: Among 1200 women who had early first trimester scans, 70 women who fulfilled our criteria of PUL and ß-HCG > 1000 mIU/ml were recruited in this study. In our study, the mean age of the participants was 30±5.6yrs, and the overall mean serum ß-HCG was 3030±522 mIU/ml. The most common outcome observed was an ectopic pregnancy, 47% in our study. We also found the rate of failing pregnancy was 27%, and that of intrauterine pregnancy (IUP) was 25%. Overall, in PUL patients diagnosed with ectopic pregnancy, 9% behaved like IUP, and 4% had an atypical trend in their ß-HCG. Those who had an IUP, 11% had a suboptimal increase in ß-HCG. Conclusion: PUL rate in our unit was 6%. Majority of the outcome of PUL was ectopic in our study. Every case of PUL should be managed based on the initial ß-HCG values, clinical assessments and upon the consent of the patient.

scholarly journals COMPARISON OF A RAPID TEST WITH bPAG ELISA IN PREGNANCY DIAGNOSIS IN COWS

2021 ◽  
Vol 52 (6) ◽  
pp. 1475-1481
Author(s):  
O. I. Dana ◽  
R. H. Mukhtar ◽  
M. O. Mohammed ◽  
H. O. Dyary
Keyword(s):  
Rapid Test ◽  
Elisa Test ◽  
Urine Samples ◽  
Reference Standard ◽  
Suitable Alternative ◽  
Pregnancy Diagnosis ◽  
Alternative Method ◽  
Blood And Urine Samples ◽  
Calving Intervals ◽  
In Pregnancy

Early pregnancy detection is vital for properly managing livestock farms by re-inseminating nonpregnant females and minimizing the calving intervals. The present investigation was executed to compare a rapid test (Dairy Cow Pregnancy Test from Span Biotech Ltd. Shenzhen, China) with a commercial bPAG ELISA test (IDEXX®) for pregnancy diagnosis in non-descriptive cows. The study also aimed to elucidate if the rapid test could be an alternative method to ELISA in the field. Blood and urine samples were collected from 43 cows to measure the concentrations of bovine pregnancy-associated glycoproteins (bPAGs) in the blood samples and detect progesterone via the rapid test in the urine samples. Examining the genital tracts was achieved after slaughtering the cows to determine the uterus’ state, used as the reference standard for both tests. The results showed that the bPAG ELISA test was more accurate in pregnancy detection than the rapid test. However, there were no statistically significant differences (P > 0.05) between both methods’ results. We conclude that the rapid test can be a suitable alternative method to the bPAG ELISA test for diagnosing pregnancy in cows in field conditions.

scholarly journals Vaginal Microbiota Characteristics of Pregnancy of Unknown Location Women in China(VMCPULW): Study Protocol for a Prospective Cohort

2021 ◽  
Author(s):  
Xuge Huang ◽  
Yingxuan Zhang ◽  
Dongying Wang ◽  
Huimin Zhang ◽  
Si Chen ◽  
...  
Keyword(s):  
Ectopic Pregnancy ◽  
Doppler Ultrasound ◽  
Color Doppler ◽  
Color Doppler Ultrasound ◽  
Vaginal Microbiota ◽  
Clinical Trial Registry ◽  
Multicenter Cohort Study ◽  
Β Hcg ◽  
Hcg Test ◽  
Pregnancy Of Unknown Location

Abstract Background: Pregnancy of unknown location (PUL) is a kind of pregnancy that has a positive beta-human chorionic gonadotropin (β-hCG) test result but the location of pregnancy cannot be determined by ultrasound. Early determination of the location of the pregnancy is important for subsequent treatment. However, there is no study on the characteristics of vaginal microbiota in pregnant women with unknown locations and a model for judging it by vaginal microbiota combined with clinical indicators. Therefore, we designed this study to compare the characteristics of vaginal microbiota in intrauterine and ectopic pregnancy populations during pregnancy with unknown locations and to establish a prediction model for pregnancy locations in PUL populations with clinical indicators.Methods: This is a prospective, multicenter cohort study. 576 eligible participants will be included in this study. Vaginal microbiota was collected from all participants at inclusion, and color Doppler ultrasound was performed weekly. After the locations of pregnancy were determined, participants of intrauterine pregnancy were followed up to their early pregnancy outcome, and participants of ectopic pregnancy were followed up until a none-pregnancy level of β-hCG was confirmed. Discussion: The regular method of judging the location of pregnancy is by color Doppler ultrasound and β-hCG test. We hope to provide earlier clinical methods of prediction for women with unknown locations of pregnancy through this study.Trial registration: Chinese Clinical Trial Registry: ChiCTR2000035378, registration date: 9 August 2020. http://www.chictr.org.cn/index.aspx

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