scholarly journals Fetal hydrops and the Incremental yield of Next generation sequencing over standard prenatal Diagnostic testing ( FIND ) study: prospective cohort study and meta‐analysis

2021 ◽  
Author(s):  
F. Mone ◽  
R. Y. Eberhardt ◽  
M. E. Hurles ◽  
D. J. McMullan ◽  
E. R. Maher ◽  
...  
Keyword(s):  
Cohort Study ◽  
Next Generation Sequencing ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Diagnostic Testing ◽  
Fetal Hydrops ◽  
Prenatal Diagnostic ◽  
Prenatal Diagnostic Testing ◽  
Generation Sequencing

scholarly journals Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis

2012 ◽  
Vol 95 (5) ◽  
pp. 1172-1181 ◽  
Author(s):  
Marieke GM Braem ◽  
N Charlotte Onland-Moret ◽  
Leo J Schouten ◽  
Anne Tjønneland ◽  
Louise Hansen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Tea Consumption

Mediterranean diet and mortality in the elderly: a prospective cohort study and a meta-analysis

2018 ◽  
Vol 120 (8) ◽  
pp. 841-854 ◽  
Author(s):  
Marialaura Bonaccio ◽  
Augusto Di Castelnuovo ◽  
Simona Costanzo ◽  
Alessandro Gialluisi ◽  
Mariarosaria Persichillo ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Mediterranean Diet ◽  
Prospective Cohort Study ◽  
Prospective Studies ◽  
Prospective Cohort ◽  
Lower Risk ◽  
Meta Analysis ◽  
The Elderly ◽  
Prolonged Survival

AbstractThe Mediterranean diet (MD) has been associated with prolonged survival in the general population, but no meta-analysis has apparently investigated the potential health benefits in relation to mortality in the elderly. We performed a longitudinal analysis on 5200 individuals aged ≥65 years identified within the general population recruited in the Moli-sani study cohort (2005–2010). Adherence to the MD was appraised by the a priori Mediterranean diet score (MDS; range 0–9). Survival estimates were derived using Cox regression and competing risk models. For the meta-analysis, PubMed and Scopus databases were searched from inception until April 2018 to identify prospective studies on the MD and death risk in the elderly. Over a median follow-up of 8·1 years, a total of 900 deaths were ascertained in the elderly sub-sample of the Moli-sani cohort. A one-point increase in the MDS was associated with lower risk of all-cause, coronary artery disease/cerebrovascular and non-cardiovascular/non-cancer mortality (multi-variable hazard ratio (HR)=0·94; 95 % CI 0·90, 0·98; HR=0·91; 95 % CI 0·83, 0·99 and HR=0·89; 95 % CI 0·81, 0·96, respectively). In a meta-analysis of seven prospective studies, including our results, for a total of 11 738 participants and 3874 deaths, one-point increment in MDS was associated with 5 % (4–7 %) lower risk of all-cause death. An inverse linear dose–response relationship was found from a meta-analysis including three studies. In conclusion, a prospective cohort study and a meta-analysis showed that closer adherence to the MD was associated with prolonged survival in elderly individuals, suggesting the appropriateness for older persons to adopt/preserve the MD to maximise their prospects for survival.

Combination Of 4T’s Score and Rapid Gel Centrifugation Assay Excludes HIT In a Prospective Cohort Study

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 3535-3535 ◽  
Author(s):  
Lori Ann Linkins ◽  
Shannon M. Bates ◽  
Agnes Y.Y. Lee ◽  
Theodore E. Warkentin
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Research Funding ◽  
Diagnostic Testing ◽  
Prediction Rule ◽  
Turnover Time ◽  
Serotonin Release ◽  
Diagnostic Strategy ◽  
Bleeding Events

Abstract The diagnosis of heparin-Induced thrombocytopenia (HIT) is based on the presence of a compatible clinical picture combined with laboratory evidence of heparin-dependent, platelet-activating IgG antibodies. The 4T's Score is a clinical prediction rule that determines the likelihood that a patient has HIT before laboratory testing is performed. A rapid assay (H/PF4-PaGIA, Diamed, Switzerland) uses gel centrifugation to measure binding of antibodies to antigen-coated polystyrene beads (15 min turnover time). The purpose of this study is to evaluate the clinical utility of a diagnostic strategy which combines the 4T's Score with a H/PF4-PaGIA result to guide management of patients with suspected HIT while awaiting results of the serotonin-release assay (SRA). Methods Prospective cohort study of 538 consecutive adult patients with suspected HIT at 4 Canadian hospitals. Physicians completed a standardized 4T's Score sheet and the H/PF4-PaGIA was performed using fresh plasma in a central lab by technologists blinded to the 4T's Score (frozen plasma was used for 85 patients due to disruptions in worldwide availability of the assay.) The SRA and an in-house IgG anti-PF4/H enzyme-immunoassay (EIA) were performed on all patients by blinded technologists. Serologically-confirmed HIT (“HIT positive”) was defined as >50% serotonin release (mean) at three reaction conditions (0.1 U/mL heparin; 0.3 U/mL heparin; enoxaparin, 0.1 U/ml), as well as inhibition (<20% release or >50% inhibition) at 100 U/mL heparin and in the presence of Fc receptor-blocking monoclonal antibody, and a positive EIA. Thrombotic events, major bleeding events, and mortality were captured at day 30. Recommendations for management of patients while awaiting the SRA: patients with a Low 4T's Score (irrespective of H/PF4-PaGIA result) and patients with an Intermediate 4T's Score and negative H/PF4-PaGIA were to receive low-dose danaparoid or fondaparinux. Therapeutic-dose non-heparin anticoagulation was recommended for all patients with an Intermediate 4T's Score and positive H/PF4-PaGIA and for all patients with a High 4T's Score irrespective of H/PF4-PaGIA result. The primary outcome measure was the frequency of management failures defined as a patient with serologically-confirmed HIT who had one of the following combinations of diagnostic testing (a) Low 4T's Score and negative H/PF4-PaGIA; (b) Low 4T's Score and positive H/PF4-PaGIA or (c) Intermediate 4T's Score and negative H/PF4-PaGIA. Results 527 patients with mean age 66.5 yr (sd 15.4) were analyzed; 11 patients with missing diagnostic testing results were excluded. Clinical outcomes of the management of patients according to the diagnostic strategy will be reported separately. Results of diagnostic accuracy of the 4T's Score and H/PF4-PaGIA compared to the SRA are provided below. The prevalence of serologically-confirmed HIT in the study population was 6.5%. Two patients with indeterminate SRAs but IgG>1.0 were reported as HIT Positive. A negative H/PF4-PaGIA result reduced the probability of HIT based on the 4T's Score from 2.5% to 0.7% (95% CI: 0.1-2.6%) in the Low group, from 6.1% to 0% (95% CI: 0-2.7%) in the Intermediate group and from 35.7% to 0% (95% CI: 0-14.3%) in the High group. A positive H/PF4-PaGIA result increased the probability of HIT based on the 4T's Score to 15.4% (Low 4T's), 38.5% (intermediate 4T's) and 83.3% (High 4T's). The proportion of management failures was 1.5% (95% CI : 0.7%-3.0%). Of the 8 patients who were identified as management failures, 2 (Low 4T's) had a negative H/PF4-PaGIA. Out of 33 HIT Positive patients, 8 (24.2%) would have been missed based on a Low 4T's Score alone and 2 (6.1%) based on negative H/PF4-PaGIA alone. The combination of a Low or Intermediate 4T's Score and a negative H/PF4-PaGIA result had a negative predictive value for HIT of 99.5% (95% CI: 98.3-99.9). Conclusions The proportion of management failures was low (1.5%) and within acceptable limits (95% CI : 0.7%-3.0%). Combining the 4T's Score with the result of H/PF4-PaGIA excludes the diagnosis of HIT in the majority of patients with a Low or Intermediate probability for HIT and raises the likelihood of HIT in patients with a High probability. Disclosures: Linkins: BioRad DiaMed: PaGIA assays purchased at cost for study Other. Bates:BioRad Diamed: provided assays for study at cost Other. Lee:BioRad Diamed: provided assays for study at cost Other. Warkentin:GSK: Research Funding; WL Gore: Consultancy; Immucor GTI Diagnostics: Research Funding; Paringenix: Consultancy; Pfizer Canada: Honoraria; BioRad Diamed: provided assays for study at cost, provided assays for study at cost Other.

scholarly journals Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project

BMJ ◽  
2014 ◽  
Vol 348 (jan21 3) ◽  
pp. f7412-f7412 ◽  
Author(s):  
G. Cesaroni ◽  
F. Forastiere ◽  
M. Stafoggia ◽  
Z. J. Andersen ◽  
C. Badaloni ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Coronary Events

Birth defects after maternal exposure to corticosteroids: Prospective cohort study and meta-analysis of epidemiological studies

Teratology ◽  
2000 ◽  
Vol 62 (6) ◽  
pp. 385-392 ◽  
Author(s):  
Laura Park-Wyllie ◽  
Paolo Mazzotta ◽  
Anne Pastuszak ◽  
Myla E. Moretti ◽  
Lizanne Beique ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Birth Defects ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Maternal Exposure
Sign in / Sign up

Export Citation Format

Share Document