scholarly journals P04.28: Population based cohort survey: prenatal diagnosis and outcome of congenital diaphragmatic hernia in UK

2005 ◽  
Vol 26 (4) ◽  
pp. 403-404
Author(s):  
M. M. Khare ◽  
S. H. Vadeyar ◽  
J. L. S. Budd ◽  
E. S. Draper
Keyword(s):  
Prenatal Diagnosis ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Population Based

scholarly journals Early population-based outcomes of infants born with congenital diaphragmatic hernia

2018 ◽  
Vol 103 (6) ◽  
pp. F517-F522 ◽  
Author(s):  
Anna-May Long ◽  
Kathryn J Bunch ◽  
Marian Knight ◽  
Jennifer J Kurinczuk ◽  
Paul D Losty
Keyword(s):  
Prognostic Factors ◽  
Prenatal Diagnosis ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Population Based ◽  
International Studies ◽  
Factors Associated ◽  
Female Sex ◽  
Pulmonary Vasodilators ◽  
The Uk

PurposeThis study aims to describe short-term outcomes of live-born infants with congenital diaphragmatic hernia (CDH) and to identify prognostic factors associated with early mortality.DesignA prospective population cohort study was undertaken between April 2009 and September 2010, collecting data on live-born infants with CDH from all 28 paediatric surgical centres in the UK and Ireland using an established surgical surveillance system. Management and outcomes are described. Prognostic factors associated with death before surgery are explored.ResultsTwo hundred and nineteen live-born infants with CDH were reported within the data collection period. There were 1.5 times more boys than girls (n=133, 61%). Thirty-five infants (16%) died without an operation. This adverse outcome was associated with female sex (adjusted OR (aOR) 3.96, 95% CI 1.66 to 9.47), prenatal diagnosis (aOR 4.99, 95% CI 1.31 to 18.98), and the need for physiological support in the form of inotropes (aOR 9.96, 95% CI 1.19 to 83.25) or pulmonary vasodilators (aOR 4.09, 95% CI 1.53 to 10.93). Significant variation in practice existed among centres, and some therapies potentially detrimental to infant outcomes were used, including pulmonary surfactant in 45 antenatally diagnosed infants (34%). Utilisation of extracorporeal membrane oxygenation was very low compared with published international studies (n=9/219, 4%). Postoperative 30-day survival was 98% for 182 infants with CDH who were adequately physiologically stabilised and underwent surgery.ConclusionThis is the first British Isles population-based study reporting outcome metrics for infants born with CDH. 16% of babies did not survive to undergo surgery. Factors associated with poor outcome included female sex and prenatal diagnosis. Early postoperative survival in those who underwent surgical repair was excellent.

Congenital diaphragmatic hernia: prenatal diagnosis permits immediate intensive care with high survival rate in isolated cases. A population-based study

2004 ◽  
Vol 24 (7) ◽  
pp. 487-493 ◽  
Author(s):  
Pierre Bétrémieux ◽  
Théophile Gaillot ◽  
Armelle de la Pintière ◽  
Alain Beuchée ◽  
Laurent Pasquier ◽  
...  
Keyword(s):  
Intensive Care ◽  
Prenatal Diagnosis ◽  
Survival Rate ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Population Based ◽  
High Survival ◽  
High Survival Rate ◽  
Population Based Study

scholarly journals Prenatal diagnosis, imaging, and prognosis in Congenital Diaphragmatic Hernia

2020 ◽  
Vol 44 (1) ◽  
pp. 51163 ◽  
Author(s):  
Anne-Gael Cordier ◽  
Francesca M. Russo ◽  
Jan Deprest ◽  
Alexandra Benachi
Keyword(s):  
Prenatal Diagnosis ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia

Outcome at 2 years of infants with congenital diaphragmatic hernia: a population-based study

2003 ◽  
Vol 75 (1) ◽  
pp. 250-256 ◽  
Author(s):  
Sophie M Jaillard ◽  
Véronique Pierrat ◽  
Angélina Dubois ◽  
Patrick Truffert ◽  
Pierre Lequien ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Population Based ◽  
Population Based Study

scholarly journals CONGENITAL DIAPHRAGMATIC HERNIA - PRENATAL DIAGNOSIS AND SURVIVAL

1999 ◽  
Vol 45 (6) ◽  
pp. 919-919
Author(s):  
E Garne ◽  
P Quataert ◽  
C De Vigan ◽  
H Mendizabal ◽  
D Igoe ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia

A Population-Based Study of Congenital Diaphragmatic Hernia in Utah: 1988-1994

1996 ◽  
Vol 87 (6) ◽  
pp. 959-963 ◽  
Author(s):  
C CANNON ◽  
G DILDY ◽  
R WARD ◽  
M VARNER ◽  
D DUDLEY
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Population Based ◽  
Population Based Study

scholarly journals PRENATAL DIAGNOSIS AND SURGICAL INNOVATIONS IN CONGENITAL DIAPHRAGMATIC HERNIA: EVALUATION OF PRE- AND POST-OPERATIVE MANAGEMENT

2014 ◽  
Vol 6 (1) ◽  
Author(s):  
R. Angotti ◽  
F. Molinaro ◽  
K. Bici ◽  
E. Cerchia ◽  
M. Sica ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Prenatal Diagnosis ◽  
Minimally Invasive ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Young Patients ◽  
Surgical Techniques ◽  
Female Ratio ◽  
Access Surgery

Introduction. Congenital diaphragmatic hernia (CDH) is still today considered a challenge from surgeons. Considerable progress in prenatal diagnosis, intensive care unit of neonates and surgical techniques, with the possibility to perform minimally access surgery, widely increased survival rates. The aim of this study is to analyze our series about long and short-term outcomes, also considering the progress made by minimally invasive techniques. Methods. The study was performed at Pediatric Surgery of Siena. It is a retrospective study that analyzed all patients with CDH (Bochdalek) treated in the last 14 years, from 2000 to 2013. Sex, side of the defect, presence of prenatal diagnosis, age of onset and symptoms, associate malformation, herniated organs, surgical technique and site of surgery, complications, recurrences, survival and followup were analyzed. Results. We included 23 patients. Five of them, were ruled out because of affected by diaphragmatic eventration or acquired diaphragmatic hernia. Forteen patients (77%) presented left CDH and 4 patients (23%) a right one. The male female ratio were 14:4. Prenatal diagnosis was performed in 5 patients (27,5%) at a mean gestational age of 29 weeks. Forteen patients (77%) had an early onset of symptoms (first day of life). Most common symptoms were respiratory distress and cyanosis; 4 patients (23%) had a late onset of symptoms, at a mean age of 9 months, and most common symptoms were failure to thrive and vomiting. Seven patients (39%) had associated malformation: common mesenterium (5 pts-71%). The colon was the most commonly herniated organ, present in 15 patients (83%), followed by small intestine in 13 patients (72%), stomach in 11 patients (61%), spleen in 9 patients (50%) and liver in 4 patients (23%). Seventeen patients (94,5%) underwent open surgery: 10 of them (59%) underwent a subcostal laparotomy approach, 7 of them (41%) underwent a supraumbelical laparotomy approach; 1 patient (5%) underwent minimally access surgery with thoracoscopy access. We performed performed surgery in the intensive care unit in 3 patients (16,5%). Six patients (33%) developed minor postoperatory complications. No patient had recurrence. Four patients died so we report a mortality rate of 23%. A follow-up investigation, with an average duration of 87 months, it is still going on in 5 patients (27,5%). Conclusions. The our survival rate was 77% and it reflects the encouraging reported data in the recent literature. These results are due to the reliability of the new resuscitation strategies, such as high-frequency oscillatory ventilation and the use of NO, the ability to perform surgery in the neonatal intensive care unit and, especially, to successfully perform minimally invasive surgery in newborn. The improvement of the survival showed the increasing of long-term morbidity end the requirement of a multidisciplinary followup. For these reasons, a multidisciplinary pathway for the management of young patients has been created, to follow them in a standardized way as early as the prenatal diagnosis.

Advances in prenatal diagnosis of congenital diaphragmatic hernia

2014 ◽  
Vol 19 (6) ◽  
pp. 331-337 ◽  
Author(s):  
Alexandra Benachi ◽  
Anne-Gaël Cordier ◽  
Mieke Cannie ◽  
Jacques Jani
Keyword(s):  
Prenatal Diagnosis ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia
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