scholarly journals VP21.06: Functional neurodevelopment evidence in a case of Chiari II with prenatal surgery of open spina bifida

2020 ◽  
Vol 56 (S1) ◽  
pp. 145-145
Author(s):  
P.I. Cavoretto ◽  
M. Canini ◽  
M. Candiani ◽  
M. Caglioni ◽  
A. Falini ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Chiari Ii ◽  
Open Spina Bifida ◽  
Prenatal Surgery

scholarly journals Impact of Brain Malformations on Neurodevelopmental Outcome in Children with a History of Prenatal Surgery for Open Spina Bifida

2021 ◽  
pp. 1-8
Author(s):  
David-Alexander Wille ◽  
Beth Padden ◽  
Ueli Moehrlen ◽  
Beatrice Latal ◽  
Sonja Schauer ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Neurodevelopmental Outcome ◽  
Cognitive Outcome ◽  
Composite Score ◽  
Third Ventriculostomy ◽  
Ventricular Size ◽  
Brain Malformations ◽  
Motor Testing ◽  
Chiari Ii ◽  
Prenatal Surgery

<b><i>Introduction:</i></b> This retrospective study investigates brain malformations and their impact on neurodevelopmental outcome in children after prenatal surgery for spina bifida (SB). <b><i>Methods:</i></b> Sixty-one patients were included. On neonatal MRI, SB-associated brain malformations were assessed. Ventricular size, ventriculo-peritoneal shunt (VPS), and endoscopic third ventriculostomy (ETV) were also documented. Neurodevelopment was assessed with the Bayley-III and correlated with brain malformations, ventricular size, and VPS/ETV placement. <b><i>Results:</i></b> Chiari II malformation was detected in all patients. Corpus callosum (CC) abnormality was noted in 40%, heterotopies in 35%, and cerebellar parenchymal defects in 11%. 96% had ventriculomegaly; in 46%, VPS/ETV was performed. Cognitive and language testing yielded results in the low-average range (Bayley-III: Cognitive Composite Score 93.6, Language Composite Score 89.7), motor testing was below average (Motor Composite Score 77.4). CC abnormalities, heterotopies, and cerebellar defects were not associated with poorer Bayley-III scores, whereas patients with severe ventriculomegaly performed poorer in all subtests, significantly so for the language composite score. Patients requiring intervention for hydrocephalus had significantly lower scores in motor testing. <b><i>Discussion/Conclusion:</i></b> Additional brain malformations in open SB do not seem to have an impact on cognitive function at 2 years of age. Severe ventriculomegaly is a risk factor for poorer cognitive outcome; hydrocephalus surgery adds an additional risk for delayed motor function.

Trans-amniotic stem cell therapy (TRASCET) minimizes Chiari-II malformation in experimental spina bifida

2015 ◽  
Vol 50 (6) ◽  
pp. 1037-1041 ◽  
Author(s):  
Beatrice Dionigi ◽  
Joseph A. Brazzo ◽  
Azra Ahmed ◽  
Christina Feng ◽  
Yaotang Wu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Spina Bifida ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Chiari Ii Malformation ◽  
Chiari Ii

Audit of prenatal and postnatal diagnosis of isolated open spina bifida in three university hospitals in The Netherlands

10.1002/uog.3 ◽  
2003 ◽  
Vol 21 (1) ◽  
pp. 48-52 ◽  
Author(s):  
M. A. G. Olde Scholtenhuis ◽  
T. E. Cohen-Overbeek ◽  
M. Offringa ◽  
P. G. Barth ◽  
Ph. Stoutenbeek ◽  
...  
Keyword(s):  
Spina Bifida ◽  
The Netherlands ◽  
University Hospitals ◽  
Postnatal Diagnosis ◽  
Open Spina Bifida

scholarly journals P25.17: Intracranial translucency and open spina bifida

2010 ◽  
Vol 36 (S1) ◽  
pp. 269-269 ◽  
Author(s):  
R. Shojai ◽  
B. Benoit ◽  
R. Chaoui ◽  
F. Bretelle ◽  
C. D'Ercole
Keyword(s):  
Spina Bifida ◽  
Intracranial Translucency ◽  
Open Spina Bifida
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