scholarly journals VP15.04: Evaluation of the novel fetalHQ technique for comprehensive cardiac function assessment of congenital heart defects

2020 ◽  
Vol 56 (S1) ◽  
pp. 112-113
Author(s):  
H. Avnet ◽  
E. Kassif ◽  
Y. Yinon ◽  
A. Weissmann‐Brenner ◽  
B. Weisz
Keyword(s):  
Cardiac Function ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
The Novel ◽  
Function Assessment

scholarly journals Connecting teratogen-induced congenital heart defects to neural crest cells and their effect on cardiac function

2014 ◽  
Vol 102 (3) ◽  
pp. 227-250 ◽  
Author(s):  
Ganga H. Karunamuni ◽  
Pei Ma ◽  
Shi Gu ◽  
Andrew M. Rollins ◽  
Michael W. Jenkins ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Neural Crest ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Neural Crest Cells

scholarly journals Ethanol exposure alters early cardiac function in the looping heart: a mechanism for congenital heart defects?

2014 ◽  
Vol 306 (3) ◽  
pp. H414-H421 ◽  
Author(s):  
Ganga Karunamuni ◽  
Shi Gu ◽  
Yong Qiu Doughman ◽  
Lindsy M. Peterson ◽  
Katherine Mai ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Congenital Heart Defects ◽  
Late Stage ◽  
Congenital Heart ◽  
Molecular Mechanisms ◽  
Imaging Modality ◽  
Heart Defects ◽  
Ethanol Exposure ◽  
The Body ◽  
Life Threatening

Alcohol-induced congenital heart defects are frequently among the most life threatening and require surgical correction in newborns. The etiology of these defects, collectively known as fetal alcohol syndrome, has been the focus of much study, particularly involving cellular and molecular mechanisms. Few studies have addressed the influential role of altered cardiac function in early embryogenesis because of a lack of tools with the capability to assay tiny beating hearts. To overcome this gap in our understanding, we used optical coherence tomography (OCT), a nondestructive imaging modality capable of micrometer-scale resolution imaging, to rapidly and accurately map cardiovascular structure and hemodynamics in real time under physiological conditions. In this study, we exposed avian embryos to a single dose of alcohol/ethanol at gastrulation when the embryo is sensitive to the induction of birth defects. Late-stage hearts were analyzed using standard histological analysis with a focus on the atrio-ventricular valves. Early cardiac function was assayed using Doppler OCT, and structural analysis of the cardiac cushions was performed using OCT imaging. Our results indicated that ethanol-exposed embryos developed late-stage valvuloseptal defects. At early stages, they exhibited increased regurgitant flow and developed smaller atrio-ventricular cardiac cushions, compared with controls (uninjected and saline-injected embryos). The embryos also exhibited abnormal flexion/torsion of the body. Our evidence suggests that ethanol-induced alterations in early cardiac function have the potential to contribute to late-stage valve and septal defects, thus demonstrating that functional parameters may serve as early and sensitive gauges of cardiac normalcy and abnormalities.

scholarly journals The novel mutations of GATA4 gene in Chinese patients with sporadic congenital heart defects

2015 ◽  
Vol 1 (4) ◽  
Author(s):  
Jing-dong Ding ◽  
Jiayi Tong ◽  
Kairu Li ◽  
Xiang Fang ◽  
Hao Li ◽  
...  
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Chinese Patients ◽  
The Novel ◽  
Novel Mutations

Minimally invasive partial inferior sternotomy for congenital heart defects in children

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
R Seipelt ◽  
T Tirilomis ◽  
T Paul ◽  
H Dörge ◽  
F Schoendube ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects
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