scholarly journals Risk of fetal loss following amniocentesis or chorionic villus sampling in twin pregnancy: systematic review and meta‐analysis

2020 ◽  
Vol 56 (5) ◽  
pp. 647-655
Author(s):  
D. Di Mascio ◽  
A. Khalil ◽  
G. Rizzo ◽  
D. Buca ◽  
M. Liberati ◽  
...  
Keyword(s):  
Systematic Review ◽  
Twin Pregnancy ◽  
Meta Analysis ◽  
Chorionic Villus ◽  
Fetal Loss ◽  
Chorionic Villus Sampling

Fetal loss after chorionic villus sampling in twin pregnancies

2021 ◽  
Author(s):  
T. Elger ◽  
R. Akolekar ◽  
A. Syngelaki ◽  
C. De Paco Matallana ◽  
F. S. Molina ◽  
...  
Keyword(s):  
Chorionic Villus ◽  
Fetal Loss ◽  
Chorionic Villus Sampling ◽  
Twin Pregnancies

Postmortem chorionic villus sampling is a better method for cytogenetic evaluation of early fetal loss than culture of abortus material

1990 ◽  
Vol 163 (5) ◽  
pp. 1505-1510 ◽  
Author(s):  
Mark Paul Johnson ◽  
Arie Drugan ◽  
Frederick C Koppitch ◽  
Wendy R Uhlmann ◽  
Mark I Evans
Keyword(s):  
Chorionic Villus ◽  
Fetal Loss ◽  
Chorionic Villus Sampling

scholarly journals Predictive value of pregnancy-associated plasma protein-A in relation to fetal loss: A systematic review and meta-analysis

2020 ◽  
Author(s):  
Zahra Hadizadeh-Talasaz ◽  
Ali Taghipour ◽  
Seyede Houra Mousavi-Vahed ◽  
Robab Latifnejad Roudsari
Keyword(s):  
Systematic Review ◽  
Likelihood Ratio ◽  
Plasma Protein ◽  
Predictive Value ◽  
Meta Analysis ◽  
Protein A ◽  
Fetal Loss ◽  
Positive Likelihood Ratio ◽  
Negative Likelihood Ratio ◽  
Forest Plot

Background: For a woman with bleeding and threatened abortion, ultrasound scan is done to confirm the viability of the fetus; however, 10-15% of the embryos are eventually aborted. Distinguishing between women with good and poor prognosis can be a helpful approach. Objective: This study aimed to review the predictive value of Pregnancy-associated Plasma Protein A (PAPP-A) in relation to the diagnosis of fetal loss. Materials and Methods: The articles published in multiple databases including Web of Science, PubMed, MEDLINE, Scopus, and Persian databases such as ISC, Magiran, and IranMedx were searched for articles published until May 2019. MeSH terms was used for searching the databases including fetal loss OR pregnancy loss OR abortion OR miscarriage with the following word using AND; Pregnancy-Associated Plasma Protein- A OR PAPP-A. Two reviewers extracted data and recorded them in a pre-defined form and assessed the quality of articles using the Newcastle-Ottawa tool. Meta-analysis was done using the Comprehensive Meta-Analysis/2.0 software and MetaDisc. Results: A total number of 16 studies were eligible for the qualitative data synthesis, out of which 8 studies were included in the meta-analysis. All studies had high and medium quality. The forest plot analysis showed a sensitivity of 57% (95% CI: 53-63%), a specificity of 83% (95% CI: 80-85%), a positive likelihood ratio of 3.52 (95% CI: 2.44- 5.07), a negative likelihood ratio of 0.54 (95% CI: 0.37-0.79), and a diagnostic odds ratio of 6.95 (95% CI: 3.58-13.50). Conclusion: PAPP-A cannot be recommended on a routine basis for predicting fetal loss and still further research with a combination of other biomarkers is required. Key words: Pregnancy-associated plasma protein-A, Fetal loss, Pregnancy, Systematic review.

scholarly journals Trisomy 21 in both fetuses in a DCDA twin pregnancy

2019 ◽  
Vol 12 (4) ◽  
pp. e227608
Author(s):  
Jiawen Ong ◽  
Arundhati Gosavi ◽  
Arijit Biswas ◽  
Mahesh Choolani
Keyword(s):  
Down Syndrome ◽  
Trisomy 21 ◽  
Twin Pregnancy ◽  
Prenatal Screening ◽  
Chorionic Villus ◽  
Screening Tests ◽  
In Vitro Fertilisation ◽  
Chorionic Villus Sampling ◽  
Detection Rates

A woman’s chances of having a child with Down syndrome increases with age. By age 40, the risk of conceiving a child with Down syndrome is about 1 in 100. We report a rare case of dizygotic dichorionic diamniotic twin pregnancy conceived via in vitro fertilisation, with both twins having trisomy 21. Both fetuses were independently detected to be at high risk of autosomal trisomy, initially via first-trimester screening and subsequently via invasive definitive diagnostic tests (ie, chorionic villus sampling and amniocentesis).Diagnosis of trisomy 21 has to be made via initial non-invasive prenatal screening, followed by further rigorous and accurate invasive pregnancy testing for confirmation. The gravity of the results necessitates high detection rates and high specificity of prenatal screening tests. Management of the patient must be multidisciplinary and supportive in nature, involving extensive and non-directive pregnancy counselling and management, genetic counselling and management of psychological distress.

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