scholarly journals OC03.06: Diagnosis of spina bifida in a routine clinical setting at the first trimester scan: a prospective multicentre study

2019 ◽  
Vol 54 (S1) ◽  
pp. 7-8 ◽  
Author(s):  
J. Tiechl ◽  
M.A. Scheier ◽  
S. Abdel Azim ◽  
K. Leitner
Keyword(s):  
Spina Bifida ◽  
Multicentre Study ◽  
Clinical Setting ◽  
First Trimester ◽  
Prospective Multicentre Study ◽  
Routine Clinical Setting ◽  
First Trimester Scan

Screening for Open Spina Bifida in a Routine Clinical Setting at the First-Trimester Scan: A Prospective Multicentre Cohort Study

2021 ◽  
pp. 1-7
Author(s):  
Johanna Tiechl ◽  
Samira Abdel Azim ◽  
Katharina Leitner ◽  
Astrid Berger ◽  
Irene Mutz-Dehbalaie ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Sensitivity And Specificity ◽  
First Trimester ◽  
Outcome Data ◽  
Prospective Multicentre Study ◽  
Multicentre Cohort Study ◽  
Routine Clinical Setting ◽  
Trimester Screening ◽  
Open Spina Bifida ◽  
Multicentre Cohort

<b><i>Objective:</i></b> The aim of this study was to investigate the performance of screening for open spina bifida (OSB) integrated into the routine first-trimester screening. <b><i>Method:</i></b> This is a prospective multicentre study of 4,755 women undergoing first-trimester ultrasound scans over a 4-year period. Measurements of the brainstem (BS) diameter and brainstem-to-occipital-bone (BSOB) distance were performed. The cisterna magna (CM) was measured in the tilted axial view. <b><i>Results:</i></b> Pregnancy outcome data were available for 4,658 fetuses included in this study. There were 5 fetuses with OSB, and in all of them, the BS/BSOB ratio and the CM measurements were abnormal. The sensitivity and specificity of a BS/BSOB ratio &#x3e;1 were 100%. The sensitivity of a CM width &#x3c;5th centile was 100%, and the specificity was 95.1%. In 4.6% of cases, the BS/BSOB ratio was between the 95th percentile and 1. In 87.1% of these cases, the CM was normal, and 12.9% had a CM below the 5th percentile. <b><i>Conclusion:</i></b> Screening for OSB is feasible in routine first-trimester scans. The BS/BSOB ratio shows a very good sensitivity and specificity. In cases with near-normal values for the BS/BSOB ratio, the CM width might be helpful for further assessment.

Prospective multicentre study of pregnancy outcome after lithium exposure during first trimester

1992 ◽  
Vol 39 (2) ◽  
pp. 160-160
Author(s):  
SJ Jacobson ◽  
K Jones ◽  
K Johnson ◽  
L Ceolin ◽  
P Kaur ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Pregnancy Outcome ◽  
First Trimester ◽  
Prospective Multicentre Study

Prospective Multicentre Study of Pregnancy Outcome After Lithium Exposure During First Trimester

1992 ◽  
Vol 47 (8) ◽  
pp. 535-536
Author(s):  
S. J. JACOBSON ◽  
K. JONES ◽  
K. JOHNSON ◽  
L. CEOLIN ◽  
P. KAUR ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Pregnancy Outcome ◽  
First Trimester ◽  
Prospective Multicentre Study

Prospective multicentre study of pregnancy outcome after lithium exposure during first trimester

The Lancet ◽  
1992 ◽  
Vol 339 (8792) ◽  
pp. 530-533 ◽  
Author(s):  
S.J. Jacobson ◽  
L. Ceolin ◽  
P. Kaur ◽  
A. Pastuszak ◽  
T. Einarson ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Pregnancy Outcome ◽  
First Trimester ◽  
Prospective Multicentre Study

Detection of spina bifida in the first trimester of gestation in association with triploidy

2017 ◽  
Author(s):  
K.K. Otaryan , C.G. Gagaev
Keyword(s):  
Spina Bifida ◽  
Early Detection ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
First Trimester ◽  
Termination Of Pregnancy ◽  
Diagnostic Tools ◽  
Prenatal Detection ◽  
Post Abortion

The case of prenatal detection of spina bifida at 12+3 weeks of gestation is described. Termination of pregnancy was performed at 13+3 weeks. Post-abortion karyotyping revealed triploidy (69XXX). Diagnostic tools for early detection of neural tube defects in the 1st trimester of gestation and subsequent appropriate management of pregnancy are discussed.

scholarly journals Geriatric fracture centre vs usual care after proximal femur fracture in older patients: what are the benefits? Results of a large international prospective multicentre study

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e039960
Author(s):  
Michael Blauth ◽  
Alexander Joeris ◽  
Elke Rometsch ◽  
Kathrin Espinoza-Rebmann ◽  
Pannida Wattanapanom ◽  
...  
Keyword(s):  
Adverse Events ◽  
Multicentre Study ◽  
Usual Care ◽  
Proximal Femur ◽  
Interdisciplinary Treatment ◽  
Proximal Femur Fracture ◽  
Geriatric Fracture ◽  
Femur Fractures ◽  
Prospective Multicentre Study ◽  
Registration Number

ObjectiveThe aim of this study was to determine the effect of treatment in geriatric fracture centres (GFC) on the incidence of major adverse events (MAEs) in patients with hip fractures compared with usual care centres (UCC). Secondary objectives included hospital-workflow and mobility-related outcomes.DesignCohort study recruiting patients between June 2015 and January 2017. Follow-up was 1 year.SettingInternational (six countries, three continents) multicentre study.Participants281 patients aged ≥70 with operatively treated proximal femur fractures.InterventionsTreatment in UCCs (n=139) or GFCs (n=142), that is, interdisciplinary treatment including regular geriatric consultation and daily physiotherapy.Outcome measuresPrimary outcome was occurrence of prespecified MAEs, including delirium. Secondary outcomes included any other adverse events, time to surgery, time in acute ward, 1-year mortality, mobility, and quality of life.ResultsPatients treated in GFCs (n=142) had a mean age of 81.9 (SD, 6.6) years versus 83.9 (SD 6.9) years in patients (n=139) treated in UCCs (p=0.013) and a higher mean Charlson Comorbidity Index of 2.0 (SD, 2.1) versus 1.2 (SD, 1.5) in UCCs (p=0.001). More patients in GFCs (28.2%) experienced an MAE during the first year after surgery compared with UCCs (7.9%) with an OR of 4.56 (95% CI 2.23 to 9.34, p<0.001). Analysing individual MAEs, this was significant for pneumonia (GFC: 9.2%; UCC: 2.9%; OR, 3.40 (95% CI 1.08 to 10.70), p=0.027) and delirium (GFC: 11.3%; UCC: 2.2%, OR, 5.76 (95% CI 1.64 to 20.23), p=0.002).ConclusionsContrary to our study hypothesis, the rate of MAEs was higher in GFCs than in UCCs. Delirium was revealed as a main contributor. Most likely, this was based on improved detection rather than a truly elevated incidence, which we interpret as positive effect of geriatric comanagement.Trial registration numberClinicalTrials.gov: NCT02297581.

Sign in / Sign up

Export Citation Format

Share Document