scholarly journals EP12.09: Umbilical vein blood flow at 11-13 weeks of gestation in twin pregnancy is associated with fetal growth

2018 ◽  
Vol 52 ◽  
pp. 252-252
Author(s):  
M. Goto ◽  
H. Takita ◽  
T. Arakaki ◽  
M. Tokunaka ◽  
T. Oba ◽  
...  
Keyword(s):  
Blood Flow ◽  
Fetal Growth ◽  
Twin Pregnancy ◽  
Umbilical Vein

316. MATERNAL DIETARY ARGININE SUPPLEMENTATION DURING LATE GESTATION IMPROVES REPRODUCTIVE EFFICIENCY IN PIGS

2010 ◽  
Vol 22 (9) ◽  
pp. 116
Author(s):  
M. J. De Blasio ◽  
C. T. Roberts ◽  
K. Kind ◽  
R. Smits ◽  
M. Nottle ◽  
...  
Keyword(s):  
Blood Flow ◽  
Birth Weight ◽  
Fetal Growth ◽  
Umbilical Vein ◽  
Late Gestation ◽  
Critical Periods ◽  
Placental Development ◽  
Pregnant Rats ◽  
Growth And Survival ◽  
Arginine Supplementation

Arginine (a non-essential amino acid) and its conversion to nitric oxide (NO) can promote formation of new blood vessels and cause vasodilation. This may reduce resistance and increase blood flow to the uterus and placenta, and the delivery of nutrients for fetal growth and survival. In pregnant rats, dietary arginine deficiency causes IUGR and increases fetal death and perinatal mortality, whereas dietary arginine supplementation reverses this. Human IUGR is associated with impaired NO synthesis, and eNOS activity in umbilical vein endothelial cells, but maternal arginine supplements have produced inconclusive results. We hypothesised that maternal arginine supplementation (MAS) in the pig (a species with naturally occurring IUGR), during late gestation, when placental angiogenesis and vascularity increase, would increase birth and placental weights. Large White (LW) and Landrace (LR) gilts (n = 285) and sows (n = 326), were fed either a control or arginine supplemented (+25 g/d arginine, Nutreco Progenos premix) diet (2.5 kg/d) in late gestation (d75-term at ~114 days). Number born, born alive, still born and mummified, birth weight and d10 weight of progeny were measured. Data were analysed using Univariate ANOVA. MAS in late gestation in gilts and sows reduced the number of still born (Con: 1.17 ± 0.13 piglets/litter; Arg: 0.84 ± 0.09 piglets/litter; P = 0.046). In LW gilts, MAS increased birth weight (Con: 1.21 ± 0.05kg; Arg: 1.34 ± 0.05kg; P < 0.05), and litter birth weight (Con: 13.38 ± 0.72 kg; Arg: 15.27 ± 0.73 kg; P < 0.05). MAS also increased birth weight in LW (Con: 1.17 ± 0.06 kg; Arg: 1.30 ± 0.06 kg; P < 0.05) and LR (Con: 1.47 ± 0.05 kg; Arg: 1.60 ± 0.05 kg; P < 0.05) sows, and reduced still borns in LW sows (Con: 1.12 ± 0.14 piglets/litter; Arg: 0.77 ± 0.09 piglets/litter; P < 0.05). MAS in late gestation improves pregnancy outcomes in terms of piglet survival and birth weight, in LW and LR gilts and sows. MAS during critical periods of placental development may enhance placental-fetal blood flow and nutrient transfer, thereby improving fetal growth and survival.

scholarly journals Placental corticotrophin releasing hormone is a modulator of fetal liver blood perfusion

2020 ◽  
Author(s):  
Satoru Ikenoue ◽  
Feizal Waffarn ◽  
Masanao Ohashi ◽  
Mamoru Tanaka ◽  
Daniel L Gillen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Body Composition ◽  
Fetal Growth ◽  
Fetal Liver ◽  
Umbilical Vein ◽  
Liver Blood Flow ◽  
Late Gestation ◽  
Ductus Venosus ◽  
Maternal Circulation ◽  
Releasing Hormone

Abstract Context Variation in fetal liver blood flow influences fetal growth and postnatal body composition. Placental corticotrophin-releasing hormone has been implicated as a key mediator of placental-fetal perfusion. Objective To determine whether circulating levels of placental corticotrophin-releasing hormone across gestation are associated with variations in fetal liver blood flow. Design Prospective cohort study Methods Fetal ultrasonography was performed at 30 weeks’ gestation to characterize fetal liver blood flow (quantified by subtracting ductus venosus flow from umbilical vein flow). Placental corticotrophin-releasing hormone was measured in maternal circulation at approximately 12, 20 and 30 weeks’ gestation. Multiple regression analysis was used to determine the proportion of variation in fetal liver blood flow explained by placental corticotrophin-releasing hormone. Co-variates included maternal age, parity, pre-pregnancy BMI, gestational weight gain, and fetal sex. Results A total of 79 uncomplicated singleton pregnancies were analyzed. Fetal liver blood flow was 68.4 ± 36.0 ml/min (mean ± SD). Placental corticotrophin-releasing hormone concentrations at 12, 20 and 30 weeks were 12.5 ± 8.1, 35.7 ± 24.5 and 247.9 ± 167.8 pg/ml, respectively. Placental corticotrophin-releasing hormone at 30 weeks, but not at 12 and 20 weeks, was significantly and positively associated with fetal liver blood flow at 30 weeks (r = 0.319, p = 0.004), and explained 10.4% of the variance in fetal liver blood flow. Conclusions Placental corticotrophin-releasing hormone in late gestation is a possible modulator of fetal liver blood flow, and may constitute a biochemical marker in clinical investigations of fetal growth and body composition.

284 Umbilical vein flow in fetal growth restriction versus small for gestational age fetuses

2021 ◽  
Vol 224 (2) ◽  
pp. S186
Author(s):  
Odessa P. Hamidi ◽  
Camille Driver ◽  
Tamara Stampalija ◽  
Sarah Martinez ◽  
Diana Gumina ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Fetal Growth Restriction ◽  
Umbilical Vein ◽  
Growth Restriction

scholarly journals Inhibitory Effects of seco-Triterpenoids from Acanthopanax sessiliflorus Fruits on HUVEC Invasion and ACE Activity

2015 ◽  
Vol 10 (9) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Jin-Won Lee ◽  
Nam-In Baek ◽  
Dae-Young Lee
Keyword(s):  
Blood Flow ◽  
Crude Extract ◽  
Umbilical Vein ◽  
Inhibitory Effect ◽  
Inhibitory Effects ◽  
Ace Inhibitory Activity ◽  
Dioic Acid ◽  
Acanthopanax Sessiliflorus ◽  
Ace Activity ◽  
Very High

This study was conducted to investigate the effects of the crude extract from Acanthopanax sessiliflorus fruits and the isolated seco-triterpenoids from the crude extract on blood flow in human umbilical vein endothelial cell (HUVEC) invasion assay and angiotensin converting enzyme (ACE) inhibitory activity assay. On the basis of DMSO, the extent of HUVECs'invasion was remarkably decreased with crude extract concentrations of 400 and 1000 μg/mL. Additionally, the extent of the HUVEC invasion inhibitory effect in 400 and 1000 μg/mL of acanthosessilioside F were 55.8% and 72.4%, respectively. In addition, the maximum extent of the HUVEC invasion inhibitory effect of 22-α-hydroxychiisanoside was 88.9%. The IC50 value of the inhibitory effect on ACE activity in the crude extract was 4 μg/mL. The isolated seco-triterpenoids, 22α-hydroxychiisanogenin, 3,4- seco-lupan-20(30)-en-3,28-dioic acid, (1 R)-1,4-epoxy-11α,22α-hydroxy-3,4- seco-lupan-20(30)-en-3,28-dioicacid, (+)-divaroside, and chiisanosidehad showed very high inhibitory effects on ACE activity, ranging from 1.8 to 2.9 üg/mL, which is much higher than the 150.0 üg/mL effect of aspirin. These results suggest that the crude extract from Acanthopanax sessiliflorus fruits and the isolated seco-triterpenoids from the crude extract enhance the blood flow effect by decreasing ACE activity.

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