scholarly journals OP19.02: First trimester umbilical vein flow in the development of large-for-gestational-age newborns

2018 ◽  
Vol 52 ◽  
pp. 122-122
Author(s):  
G. Rizzo ◽  
M. Veglia ◽  
I. Mappa ◽  
A. Alessio ◽  
A. Quarto ◽  
...  
Keyword(s):  
Gestational Age ◽  
Umbilical Vein ◽  
First Trimester ◽  
Large For Gestational Age

scholarly journals Role of first‐trimester umbilical vein blood flow in predicting large‐for‐gestational age at birth

2020 ◽  
Vol 56 (1) ◽  
pp. 67-72 ◽  
Author(s):  
G. Rizzo ◽  
I. Mappa ◽  
V. Bitsadze ◽  
M. Słodki ◽  
J. Khizroeva ◽  
...  
Keyword(s):  
Blood Flow ◽  
Gestational Age ◽  
Umbilical Vein ◽  
First Trimester ◽  
Large For Gestational Age ◽  
Gestational Age At Birth ◽  
Age At Birth

scholarly journals A first trimester prediction model for large for gestational age infants: a preliminary study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Francesca Monari ◽  
Daniela Menichini ◽  
Ludovica Spano’ Bascio ◽  
Giovanni Grandi ◽  
Federico Banchelli ◽  
...  
Keyword(s):  
Prediction Model ◽  
Gestational Age ◽  
Predictive Accuracy ◽  
First Trimester ◽  
University Hospital ◽  
Large For Gestational Age ◽  
Aneuploidy Screening ◽  
Maternal Characteristics ◽  
Targeted Interventions ◽  
Increased Risk

Abstract Background Large for gestational age infants (LGA) have increased risk of adverse short-term perinatal outcomes. This study aims to develop a multivariable prediction model for the risk of giving birth to a LGA baby, by using biochemical, biophysical, anamnestic, and clinical maternal characteristics available at first trimester. Methods Prospective study that included all singleton pregnancies attending the first trimester aneuploidy screening at the Obstetric Unit of the University Hospital of Modena, in Northern Italy, between June 2018 and December 2019. Results A total of 503 consecutive women were included in the analysis. The final prediction model for LGA, included multiparity (OR = 2.8, 95% CI: 1.6–4.9, p = 0.001), pre-pregnancy BMI (OR = 1.08, 95% CI: 1.03–1.14, p = 0.002) and PAPP-A MoM (OR = 1.43, 95% CI: 1.08–1.90, p = 0.013). The area under the ROC curve was 70.5%, indicating a satisfactory predictive accuracy. The best predictive cut-off for this score was equal to − 1.378, which corresponds to a 20.1% probability of having a LGA infant. By using such a cut-off, the risk of LGA can be predicted in our sample with sensitivity of 55.2% and specificity of 79.0%. Conclusion At first trimester, a model including multiparity, pre-pregnancy BMI and PAPP-A satisfactorily predicted the risk of giving birth to a LGA infant. This promising tool, once applied early in pregnancy, would identify women deserving targeted interventions. Trial registration ClinicalTrials.gov NCT04838431, 09/04/2021.

scholarly journals Ductus Venosus Agenesis and Fetal Malformations: Report of Four Cases

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Alexandra Matias ◽  
Diana Pacheco ◽  
Otilia Brandão ◽  
Nuno Montenegro
Keyword(s):  
Gestational Age ◽  
Umbilical Vein ◽  
Pregnancy Termination ◽  
Rare Condition ◽  
Normal Karyotype ◽  
First Trimester ◽  
The Other ◽  
Careful Examination ◽  
Ductus Venosus ◽  
Imaging Findings

Background: The agenesis of the ductus venosus (DVA) is a rare condition with a variable prognosis that relies partly on the presence of associated conditions. Therefore, the prenatal evaluation should include a careful examination of fetal circulation, particularly the umbilical and portal venous malformations.Methods In this study, we describe four cases of DVA diagnosed at our institution. For each case, we access the patient’s files in order to extract the following information: gestational age, umbilical vein connection, pre-natal imaging findings, gestational age at delivery or at pregnancy termination, fetal outcomes, post-natal imaging findings, post-mortem findings and karyotype.Results From the four cases included, two were diagnosed in the first trimester and the other two cases in the second trimester of gestation. Prenatal ultrasound studies revealed an intrahepatic shunt in one case and an extrahepatic shunt in three cases. In one case, the karyotype was not performed, whereas the other three had a normal karyotype. Cardiac anomalies were found in three of the four fetuses. All but one case presented with extracardiac abnormalities. None of the cases developed hydrops. Two cases are currently alive and well, one termination of pregnancy occurred at 25 weeks of gestation and one case died at 14 days during surgical correction of a complex cardiac malformation.Conclusions Clinicians should be aware of different and important findings during the fetal examination, which can be indicative of a DVA, and, when suspected, serial revaluations should be scheduled in order to identify any malformation.

scholarly journals The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

2021 ◽  
pp. 1-6
Author(s):  
Cenk Soysal ◽  
İsmail Biyik ◽  
Özlem Erten ◽  
Onur Ince ◽  
Hatice Sari ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Protein A ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Maternal Serum ◽  
Large For Gestational Age ◽  
Aneuploidy Screening ◽  
Beta Human Chorionic Gonadotropin

OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma and the predicted weight at birth: Small for gestational age and large for gestational age. STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent first-trimester aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational age, and those over the 90th percentile were defined as large for gestational age. RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735). CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for gestational age However, due to its low correlation, it is not a suitable screening test for clinical practice.

scholarly journals First-trimester screening for large-for-gestational-age infants

2012 ◽  
Vol 39 (4) ◽  
pp. 389-395 ◽  
Author(s):  
W. Plasencia ◽  
E. González Dávila ◽  
V. Tetilla ◽  
E. Padrón Pérez ◽  
J. A. García Hernández ◽  
...  
Keyword(s):  
Gestational Age ◽  
First Trimester ◽  
Large For Gestational Age ◽  
First Trimester Screening ◽  
Trimester Screening

scholarly journals Early pregnancy hyperglycaemia as a significant predictor of large for gestational age neonates

2022 ◽  
Author(s):  
Imasha Upulini Jayasinghe ◽  
Iresha Sandamali Koralegedara ◽  
Suneth Buddhika Agampodi
Keyword(s):  
Diabetes Mellitus ◽  
Birth Weight ◽  
Early Pregnancy ◽  
Gestational Age ◽  
First Trimester ◽  
World Health ◽  
Large For Gestational Age ◽  
Evaluation Procedure ◽  
Who Criteria ◽  
In Pregnancy

Abstract Aims We aimed to determine the effect of early pregnancy hyperglycaemia on having a large for gestational age (LGA) neonate. Methods A prospective cohort study was conducted among pregnant women in their first trimester. One-step plasma glucose (PG) evaluation procedure was performed to assess gestational diabetes mellitus (GDM) and diabetes mellitus (DM) in pregnancy as defined by the World Health Organization (WHO) criteria with International Association of Diabetes in Pregnancy Study Group (IADPSG) thresholds. The main outcome studied was large for gestational age neonates (LGA). Results A total of 2,709 participants were recruited with a mean age of 28 years (SD = 5.4) and a median gestational age (GA) of eight weeks (interquartile range [IQR] = 2). The prevalence of GDM in first trimester (T1) was 15.0% (95% confidence interval [CI] = 13.7–16.4). Previously undiagnosed DM was detected among 2.5% of the participants. Out of 2,285 live births with a median delivery GA of 38 weeks (IQR = 3), 7.0% were LGA neonates. The cumulative incidence of LGA neonates in women with GDM and DM was 11.1 and 15.5 per 100 women, respectively. The relative risk of having an LGA neonate among women with DM and GDM was 2.30 (95% CI = 1.23–4.28) and 1.80 (95% CI = 1.27–2.53), respectively. The attributable risk percentage of a LGA neonate for hyperglycaemia was 15.01%. T1 fasting PG was significantly correlated with both neonatal birth weight and birth weight centile. Conclusions The proposed WHO criteria for hyperglycaemia in pregnancy are valid, even in T1, for predicting LGA neonates. The use of IADPSG threshold for Fasting PG, for risk assessment in early pregnancy in high-risk populations is recommended.

scholarly journals Women and Pregnancies as an Immediate Target against the Obesity Epidemic

2021 ◽  
pp. 31-34
Author(s):  
Pierre-Yves Robillard
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Gestational Age ◽  
First Trimester ◽  
Large For Gestational Age ◽  
Current Debate ◽  
Obesity Epidemic ◽  
Gestational Weight ◽  
First Trimester Of Pregnancy ◽  
Morbid Obese

The author wishes to enlarge an important current debate among obstetricians trying to sensitize specialists of obesity/endocrinology/nutrition, and make them aware of a possible very important debate: having a “normal shaped” baby (neither too small, nor too big,10% of SGA, small for gestational age and 10% of LGA, large for gestational age), is possible by an optimal gestational weight gain (optGWG) during pregnancy. This is a simple mathematical linear equation, y= ax+b (y being optimal gestational weight gain, optGWG, x being pre-pregnancy body mass index, ppBMI). Beginning with severe obesity (36 kg/m²), women should not gain weight during their pregnancy, while they should lose weight in higher BMIs (e.g. losing 6 kg for a 40 kg/m² morbid obese). This is predictable since the first trimester of pregnancy.

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