scholarly journals OC02.05: The influence of body mass index on fetal fraction increase and test failure rate in prenatal cell-free DNA testing

2018 ◽  
Vol 52 ◽  
pp. 4-4
Author(s):  
D. Rolnik ◽  
M. Reddy ◽  
Y. Yong ◽  
T. Lee ◽  
A. McLennan ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Failure Rate ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna ◽  
Fraction Increase ◽  
Fetal Fraction ◽  
Test Failure

Influence of Body Mass Index on Fetal Fraction Increase With Gestation and Cell-Free DNA Test Failure

2018 ◽  
Vol 132 (2) ◽  
pp. 436-443 ◽  
Author(s):  
Daniel L. Rolnik ◽  
Yuanqi Yong ◽  
Timothy J. Lee ◽  
Cheryl Tse ◽  
Andrew C. McLennan ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cell Free Dna ◽  
Dna Test ◽  
Free Dna ◽  
Fraction Increase ◽  
Fetal Fraction ◽  
Test Failure

scholarly journals Association between fetal fraction on cell‐free DNA testing and first‐trimester markers for pre‐eclampsia

2018 ◽  
Vol 52 (6) ◽  
pp. 722-727 ◽  
Author(s):  
D. L. Rolnik ◽  
F. da Silva Costa ◽  
T. J. Lee ◽  
M. Schmid ◽  
A. C. McLennan
Keyword(s):  
First Trimester ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna ◽  
Fetal Fraction

Effects of medication intake in early pregnancy on the fetal fraction of cell‐free DNA testing

2019 ◽  
Vol 39 (5) ◽  
pp. 361-368
Author(s):  
Maggie Kuhlmann‐Capek ◽  
Giuseppe Chiossi ◽  
Prapti Singh ◽  
Luis Monsivais ◽  
Violetta Lozovyy ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Medication Intake ◽  
Free Dna ◽  
Fetal Fraction

scholarly journals Association between low fetal fraction in cell‐free DNA testing and adverse pregnancy outcome: A systematic review

2021 ◽  
Author(s):  
Peter G. Scheffer ◽  
Soetinah A.M. Wirjosoekarto ◽  
Ellis C. Becking ◽  
Marjan M. Weiss ◽  
Caroline J. Bax ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnancy Outcome ◽  
Adverse Pregnancy Outcome ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna ◽  
Adverse Pregnancy ◽  
Fetal Fraction

scholarly journals 225: Clinical implications of low fetal fraction in pregnancies with negative cell free DNA testing

2019 ◽  
Vol 220 (1) ◽  
pp. S163
Author(s):  
Mark A. Clapp ◽  
Lydia L. Shook ◽  
Penelope A. Roberts ◽  
Ilona T. Goldfarb ◽  
Sarah N. Bernstein
Keyword(s):  
Clinical Implications ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna ◽  
Negative Cell ◽  
Fetal Fraction

Significant Correlation Between Maternal Body Mass Index at Delivery and in the Second Trimester, and Second Trimester Circulating Total Cell-free DNA Levels

2009 ◽  
Vol 16 (3) ◽  
pp. 274-279 ◽  
Author(s):  
Olav Lapaire ◽  
Thorsten Volgmann ◽  
Simon Grill ◽  
Irène Hösli ◽  
Rosanna Zanetti-Daellenbach ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Total Cell ◽  
Maternal Body Mass Index ◽  
Second Trimester ◽  
Maternal Body ◽  
Cell Free Dna ◽  
Free Dna

scholarly journals Low Fetal Fraction of Cell-free DNA Identified by Non-invasive Prenatal DNA Testing: Possible Causes, Clinical Significance, and Tactics

Doctor Ru ◽  
2020 ◽  
Vol 19 (8) ◽  
pp. 49-54
Author(s):  
E.V. Kudryavtseva ◽  
◽  
V.V. Kovalev ◽  
I.I. Baranov ◽  
I.V. Kanivets ◽  
...  
Keyword(s):  
Body Weight ◽  
Prenatal Diagnosis ◽  
Trisomy 18 ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Non Invasive ◽  
Monosomy X ◽  
Free Dna ◽  
Repeat Procedure ◽  
Fetal Fraction

Study Objective: To compare the rates of fetal chromosomal abnormalities (CA) detected during initial non-invasive prenatal DNA testing (NIPT) with the rates of CA found through repeat NIPT in patients with low fetal fraction or low quality of cell-free embryonic DNA. Study Design: This was a retrospective cohort study. Materials and Methods: Twenty-one thousand forty-two women who underwent NIPT in Russia between 2013 and 2018 were included in the study. The main group comprised 1,025 of the 1,044 patients with uninformative results (low fetal fraction result, making it impossible to assess the risk of CA), who consented to repeat NIPT. The control group was made up of 19,998 women who had informative results of initial NIPT. The exclusion group comprised women with low fetal fraction who declined repeat screening. The study method was targeted NIPT. Blood samples were taken from a vein and centrifuged to obtain plasma. Fetal cell-free DNA was analyzed by next-generation sequencing (NGS), a method patented by Natera for sequencing single nucleotide polymorphisms. Study Results: Initial NIPT was uninformative in 1,044 (5%) of the patients and repeat procedure yielded informative results in 821 (80.1%) out of 1,025 patients. Among the patients with informative results from the initial study, the rate of chromosomal aneuploidies was 2.4%. In the group of women with informative results from the repeat procedure, fetal CA were detected in 27 (3.3%) cases. In the subgroup of women with informative results only after a third NIPT, the prevalence of CA was 9.3% (seven out of 75 cases). The study showed that in women carrying fetuses with trisomy 18 or 13 or monosomy X, mean fetal fraction in the first trimester was significantly lower than normal. In the second trimester, significantly lower than normal fetal fraction was observed in women carrying fetuses with trisomy 18 or monosomy X. There was a statistically significant difference in fetal fraction levels between patients with body weight <50 kg and those with body weight 80-89 kg or above (р<0.05). Conclusion: The probability of detecting CA by repeat NIPT is significantly higher than in an initial procedure. If initial testing is not informative, it should be repeated. If the second procedure also fails to yield informative results, invasive prenatal diagnosis should be considered. Fetal fraction levels are lower in heavier women. Thus, other methods of prenatal diagnosis should be recommended for overweight and obese women. Keywords: non-invasive prenatal DNA testing, fetal fraction, prenatal diagnosis, Down syndrome.

Sign in / Sign up

Export Citation Format

Share Document