scholarly journals Metformin for prevention of hypertensive disorders of pregnancy in women with gestational diabetes or obesity: systematic review and meta‐analysis of randomized trials

2018 ◽  
Vol 52 (6) ◽  
pp. 706-714 ◽  
Author(s):  
E. Kalafat ◽  
Y. E. Sukur ◽  
A. Abdi ◽  
B. Thilaganathan ◽  
A. Khalil
Keyword(s):  
Systematic Review ◽  
Gestational Diabetes ◽  
Randomized Trials ◽  
Meta Analysis ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders

scholarly journals The Effect of Probiotics or Synbiotics on the Hypertensive Disorders of Pregnant Women with Gestational Diabetes: A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Rouhina Movaghar ◽  
Azizeh Farshbaf-Khalili ◽  
khadijeh Hajizade ◽  
Mehdi Ebrahimpour MirzaRezaei ◽  
Mahnaz Shahnazi
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Gestational Diabetes ◽  
Pregnancy Outcomes ◽  
Meta Analysis ◽  
Total Sample ◽  
Randomized Controlled ◽  
Hypertensive Disorders ◽  
Inflammatory Drugs ◽  
Synbiotic Supplementation

AbstractIntroduction:Antioxidants and anti-inflammatory drugs have been suggested to treat preeclampsia. This systematic review and meta-analysis was conducted to investigate the efficacy of probiotic or synbiotic supplementation on hypertensive disorders in women with gestational diabetes mellitus (GDM).Methods:The databases including Cochrane, Embase, Ovid, ProQuest, Scopus, Web of Science, and PubMed were systematically searched for collecting the randomized controlled trials (RCTs) investigating the efficacy of probiotic or synbiotic supplementation versus placebo on hypertensive disorders and pregnancy outcomes in GDM until July 2020.Results:Five RCTs with a total sample size of 402 women were included in the meta-analysis. There was no significant decline in systolic blood pressure (standardized mean difference [SMD] = -3.41, 95% confidence interval [CI] = -8.32 to 1.50, P = 0.17), diastolic blood pressure (SMD = -5.11, 95% CI = -14.20 to -3.98, P = 0.27), preeclampsia (odds ratio [OR] = 1.56, 95% CI = 0.61 to 3.98, P = 0.35), cesarean section (OR = 0.52, 95% CI = 0.18 to 1.50, P = 0.23), and macrosomia (OR = 0.81, 95% CI = 0.41 to 1.57, P = 0.53). No significant increase was observed in terms of 5-minute Apgar (SMD = 0.16, 95% CI = -0.06 to 0.39, P = 0.15, I2= 0%), birth weight (SMD = -0.18, 95% CI = -0.43 to 0.06, P = 0.13, I2= 0%), and gestational age (SMD = 0.13, 95% CI = -0.11 to 0.37, P = 0.28, I2= 0%).Conclusion:Probiotic or synbiotic supplements are not associated with significant effects on pregnancy outcomes in GDM. However, due to the limited number of studies in this regard and heterogeneity between studies, future high-quality RCTs are recommended.

scholarly journals Assisted Reproductive Technology and Hypertensive Disorders of Pregnancy: Systematic Review and Meta-Analyses

2021 ◽  
Author(s):  
Hui Ju Chih ◽  
Flavia Elias ◽  
Laura Gaudet ◽  
Maria Velez
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Embryo Transfer ◽  
Meta Analysis ◽  
Oocyte Donation ◽  
Reproductive Technology ◽  
Frozen Embryo Transfer ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Singleton Pregnancies

Abstract BackgroundHypertensive disorders of pregnancy (HDP) is one of the most common pregnancy complications and causes of maternal morbidity and mortality. Many cohort studies were conducted to study adverse pregnancy outcomes associated with pregnancies from assisted reproductive technology. We aimed to comprehensively review all available evidence to date to compare the odds of HDP and preeclampsia between pregnancies achieved by in vitro fertilization (IVF) and spontaneous pregnancies.MethodsWe conducted a systematic review and meta-analysis based on cohort studies identified from EMBASE, MEDLINE, and Cochrane Library (up to 2020) and manually using a structured search strategy. Cohort studies that compared pregnancies after IVF with or without intracytoplasmic sperm fertilization (ICSI) and SC with HDP or preeclampsia as the outcome of interest were included. The control group was women who conceived spontaneously without ART or fertility medications. Studies published in English, French, Chinese, and Portuguese were reviewed. Eligibility and quality of studies were evaluated by two reviewers independently. Quality assessment was conducted using the Newcastle Ottawa Scale (NOS) for Cohort Studies. The pooled results were reported in odds ratios (OR) with 95% confidence intervals based on random effects models. I-squared (I2) test was used to evaluate heterogeneity and publication bias was assessed using funnel plots.ResultsSeventy-eight studies were included after a screening of 1,879 abstracts and 275 full text articles. Compared to SC, IVF/ICSI singleton pregnancies (OR 1.63; 95% CI 1.54-1.74; I2 = 79%) and multiple pregnancies (OR 1.31; 95% CI 1.18-1.47; I2 = 73%) were both associated with higher odds of HDP. Singleton pregnancies with oocyte donation had the highest odds of HDP out of all groups analyzed (OR 4.11; 95% CI 2.75-6.16; I2 = 85%). Frozen embryo transfer resulted in higher odds of HDP (OR 1.74; 95% CI 1.58-1.92; I2 = 55%) than fresh embryo transfer (OR 1.43; 95% CI 1.33-1.53; I2 = 72%). Similar findings for preeclampsia were also reported.ConclusionsOur meta-analysis confirmed that IVF/ICSI pregnancies are at high odds of HDP and preeclampsia than SC, irrespective of the plurality. The odds were especially high in frozen embryo transfer and oocyte donation pregnancies.

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