scholarly journals EP14.13: The association between fetal abdominal circumference growth velocity and placental biomarkers in appropriate-for-gestational-age neonates

2017 ◽  
Vol 50 ◽  
pp. 318-318
Author(s):  
M. Hendrix ◽  
D. Kramer ◽  
D. Gavilanes ◽  
S. Al Nasiry ◽  
M. Spaanderman
Keyword(s):  
Gestational Age ◽  
Growth Velocity ◽  
Abdominal Circumference ◽  
Appropriate For Gestational Age

31 Fetal abdominal circumference growth velocity as a predictor of neonatal outcome and birth weight in appropriate-for-gestational-age neonates

2016 ◽  
Vol 6 (3) ◽  
pp. 192-193
Author(s):  
Manouk Hendrix ◽  
Sander Van Kuijk ◽  
Desire Kramer ◽  
Danilo Gavilanes ◽  
Marc Spaanderman ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Growth Velocity ◽  
Neonatal Outcome ◽  
Abdominal Circumference ◽  
Appropriate For Gestational Age

scholarly journals Appropriate-for-gestational-age infants who exhibit reduced antenatal growth velocity display postnatal catch-up growth

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0238700 ◽  
Author(s):  
Emma J. McLaughlin ◽  
Richard J. Hiscock ◽  
Alice J. Robinson ◽  
Lisa Hui ◽  
Stephen Tong ◽  
...  
Keyword(s):  
Gestational Age ◽  
Growth Velocity ◽  
Appropriate For Gestational Age ◽  
Catch Up

scholarly journals Reduced growth velocity from the mid-trimester is associated with placental insufficiency in fetuses born at a normal birthweight

BMC Medicine ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Lucy M. Kennedy ◽  
Stephen Tong ◽  
Alice J. Robinson ◽  
Richard J. Hiscock ◽  
Lisa Hui ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Gestational Age ◽  
Growth Velocity ◽  
Clinical Care ◽  
Unmet Need ◽  
Placental Insufficiency ◽  
Abdominal Circumference ◽  
Adaptation To Hypoxia ◽  
Fat Percentage ◽  
Increased Risk

Abstract Background Fetal growth restriction (FGR) due to placental insufficiency is a major risk factor for stillbirth. While small-for-gestational-age (SGA; weight < 10th centile) is a commonly used proxy for FGR, detection of FGR among appropriate-for-gestational-age (AGA; weight ≥ 10th centile) fetuses remains an unmet need in clinical care. We aimed to determine whether reduced antenatal growth velocity from the time of routine mid-trimester ultrasound is associated with antenatal, intrapartum and postnatal indicators of placental insufficiency among term AGA infants. Methods Three hundred and five women had biometry measurements recorded from their routine mid-trimester (20-week) ultrasound, at 28 and 36 weeks’ gestation, and delivered an AGA infant. Mid-trimester, 28- and 36-week estimated fetal weight (EFW) and abdominal circumference (AC) centiles were calculated. The EFW and AC growth velocities between 20 and 28 weeks, and 20–36 weeks, were examined as predictors of four clinical indicators of placental insufficiency: (i) low 36-week cerebroplacental ratio (CPR; CPR < 5th centile reflects cerebral redistribution—a fetal adaptation to hypoxia), (ii) neonatal acidosis (umbilical artery pH < 7.15) after the hypoxic challenge of labour, (iii) low neonatal body fat percentage (BF%) reflecting reduced nutritional reserve and (iv) placental weight < 10th centile. Results Declining 20–36-week fetal growth velocity was associated with all indicators of placental insufficiency. Each one centile reduction in EFW between 20 and 36 weeks increased the odds of cerebral redistribution by 2.5% (odds ratio (OR) = 1.025, P = 0.001), the odds of neonatal acidosis by 2.7% (OR = 1.027, P = 0.002) and the odds of a < 10th centile placenta by 3.0% (OR = 1.030, P < 0.0001). Each one centile reduction in AC between 20 and 36 weeks increased the odds of neonatal acidosis by 3.1% (OR = 1.031, P = 0.0005), the odds of low neonatal BF% by 2.8% (OR = 1.028, P = 0.04) and the odds of placenta < 10th centile by 2.1% (OR = 1.021, P = 0.0004). Falls in EFW or AC of > 30 centiles between 20 and 36 weeks were associated with two–threefold increased relative risks of these indicators of placental insufficiency, while low 20–28-week growth velocities were not. Conclusions Reduced growth velocity between 20 and 36 weeks among AGA fetuses is associated with antenatal, intrapartum and postnatal indicators of placental insufficiency. These fetuses potentially represent an important, under-recognised cohort at increased risk of stillbirth. Encouragingly, this novel fetal assessment would require only one additional ultrasound to current routine care, and adds to the potential benefits of routine 36-week ultrasound.

Growth velocity of preterm appropriate for gestational age newborns

10.2223/1228 ◽  
2004 ◽  
Vol 80 (5) ◽  
pp. 417-424 ◽  
Author(s):  
Lêni M. Anchieta ◽  
César C. Xavier ◽  
Enrico A. Colosimo
Keyword(s):  
Gestational Age ◽  
Growth Velocity ◽  
Appropriate For Gestational Age

scholarly journals Fetal growth velocity references from a Chinese population–based fetal growth study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tianchen Wu ◽  
Xiaoli Gong ◽  
Yangyu Zhao ◽  
Lizhen Zhang ◽  
Yiping You ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Gestational Age ◽  
Growth Velocity ◽  
Chinese Population ◽  
Perinatal Outcomes ◽  
Population Based ◽  
Fetal Ultrasound ◽  
Ultrasound Measurements ◽  
Appropriate For Gestational Age ◽  
Adverse Perinatal Outcomes

Abstract Background Fetal growth velocity standards have yet to be established for the Chinese population. This study aimed to establish such standards suitable for the Chinese population. Methods We performed a multicenter, population–based longitudinal cohort study including 9075 low–risk singleton pregnant women. Data were collected from the clinical records of 24 hospitals in 18 provinces of China. Demographic characteristics, reproductive history, fetal ultrasound measurements, and perinatal outcome data were collected. The fetal ultrasound measurements included biparietal diameter (BPD), abdominal circumference (AC), head circumference (HC), and femur diaphysis length (FDL). We used linear mixed models with cubic splines to model the trajectory of four ultrasound parameters and estimate fetal weight. Fetal growth velocity was determined by calculating the first derivative of fetal size curves. We also used logistic regression to estimate the association between fetal growth velocities in the bottom 10th percentile and adverse perinatal outcomes. Results Fetal growth velocity was not consistent over time or among individuals. The estimated fetal weight (EFW) steadily increased beginning at 12 gestational weeks and peaked at 35 gestational weeks. The maximum velocity was 211.71 g/week, and there was a steady decrease in velocity from 35 to 40 gestational weeks. The four ultrasound measurements increased in the early second trimester; BPD and HC peaked at 13 gestational weeks, AC at 14 gestational weeks, and FDL at 15 gestational weeks. BPD and HC also increased from 19 to 24 and 19 to 21 gestational weeks, respectively. EFW velocity in the bottom 10th percentile indicated higher risks of neonatal complications (odds ratio [OR] = 2.23, 95% confidence interval [CI]: 1.79–2.78) and preterm birth < 37 weeks (OR = 3.68, 95% CI: 2.64–5.14). Sensitivity analyses showed that EFW velocity in the bottom 10th percentile was significantly associated with more adverse pregnancy outcomes for appropriate–for–gestational age neonates. Conclusions We established fetal growth velocity curves for the Chinese population based on real–world clinical data. Our findings demonstrated that Chinese fetal growth patterns are somewhat different from those of other populations. Fetal growth velocity could provide more information to understand the risk of adverse perinatal outcomes, especially for appropriate–for–gestational age neonates.

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