scholarly journals P24.01: Fetal brain anomalies detection during the first trimester: expanding the scope of antenatal sonography

2017 ◽  
Vol 50 ◽  
pp. 231-231
Author(s):  
E. Katorza ◽  
I. Gat ◽  
N. Duvdevani ◽  
E. Barzilay ◽  
R. Achiron
Keyword(s):  
Fetal Brain ◽  
First Trimester ◽  
Brain Anomalies ◽  
Antenatal Sonography

Fetal brain anomalies detection during the first trimester: expanding the scope of antenatal sonography

2017 ◽  
Vol 31 (4) ◽  
pp. 506-512 ◽  
Author(s):  
Eldad Katorza ◽  
Itai Gat ◽  
Nir Duvdevani ◽  
Nir Meller ◽  
Noam Pardo ◽  
...  
Keyword(s):  
Fetal Brain ◽  
First Trimester ◽  
Brain Anomalies ◽  
Antenatal Sonography

Case 3: A Term Newborn with Intrauterine Growth Restriction and Severe Fetal Brain Anomalies

NeoReviews ◽  
2018 ◽  
Vol 19 (10) ◽  
pp. e616-e619
Author(s):  
Fatimo Biobaku ◽  
Kikelomo Babata ◽  
Hayley Friedman ◽  
Amanda Goddard ◽  
Elizabeth Yen
Keyword(s):  
Intrauterine Growth Restriction ◽  
Fetal Brain ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Term Newborn ◽  
Brain Anomalies

scholarly journals Prenatal Detection of Fetal Anomalies at the 11- to 13-Week Scan—Part I: Brain, Face and Neck

2013 ◽  
Vol 7 (4) ◽  
pp. 359-368 ◽  
Author(s):  
Tamara Illescas ◽  
Waldo Sepulveda ◽  
Begona Adiego ◽  
Pilar Martinez-Ten
Keyword(s):  
Fetal Brain ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Ultrasound Screening ◽  
Second Trimester ◽  
Fetal Anomalies ◽  
Prenatal Detection ◽  
Ultrasound Findings ◽  
First Trimester Of Pregnancy ◽  
Structural Anomalies

ABSTRACT In the last 20 years, the role of first-trimester ultrasound screening has expanded from individual calculation of the risk of aneuploidy through measurement of the nuchal translucency to a powerful technique to evaluate important aspects of the fetal anatomy. Traditionally, the full anatomy scan for detection of structural anomalies has been performed in the second trimester of pregnancy. However, with the implementation of the first-trimester scan at 11 to 13 weeks of gestation many of the structural anomalies traditionally detected in the second trimester can now be identified earlier in pregnancy. In the first part of this review we discuss the main ultrasound findings that may facilitate the prenatal detection of fetal brain, face and neck abnormalities in the first trimester of pregnancy. How to cite this article Sepulveda W, Illescas T, Adiego B, Martinez-Ten P. Prenatal Detection of Fetal Anomalies at the 11- to 13-Week Scan—Part I: Brain, Face and Neck. Donald School J Ultrasound Obstet Gynecol 2013;7(4):359-368.

scholarly journals Maternal iodine status in a multi-ethnic UK birth cohort: associations with autism spectrum disorder

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Kirsten Jade Cromie ◽  
Diane Erin Threapleton ◽  
Charles Jonathan Peter Snart ◽  
Elizabeth Taylor ◽  
Dan Mason ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Thyroid Hormones ◽  
Iodine Deficiency ◽  
Urinary Iodine ◽  
Fetal Brain ◽  
First Trimester ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Iodine Status ◽  
Increased Risk

Abstract Background Maternal iodine requirements increase during pregnancy to supply thyroid hormones essential for fetal brain development. Maternal iodine deficiency can lead to hypothyroxinemia, a reduced fetal supply of thyroid hormones which, in the first trimester, has been linked to an increased risk of autism spectrum disorder (ASD) in the child. No study to date has explored the direct link between maternal iodine deficiency and diagnosis of ASD in offspring. Methods Urinary iodine concentrations (UIC) and iodine/creatinine ratios (I:Cr) were measured in 6955 mothers at 26–28 weeks gestation participating in the Born in Bradford (BiB) cohort. Maternal iodine status was examined in relation to the probability of a Read (CTV3) code for autism being present in a child’s primary care records through a series of logistic regression models with restricted cubic splines. Results Median (inter-quartile range) UIC was 76 μg/L (46, 120) and I:Cr was 83 μg/g (59, 121) indicating a deficient population according to WHO guidelines. Ninety two children (1·3%) in our cohort had received a diagnosis of ASD by the census date. Overall, there was no evidence to support an association between I:Cr or UIC and ASD risk in children aged 8–12 years (p = 0·3). Conclusions There was no evidence of an increased clinical ASD risk in children born to mothers with mild-to-moderate iodine deficiency at 26 weeks gestation. Alternative functional biomarkers of exposure and a wider range of conditions may provide further insight.

Abnormality of “butterfly” sign of choroid plexus: new ultrasound marker of fetal open spinal defects in the first trimester

2020 ◽  
Author(s):  
M.A. Esetov, , G.M. Bekeladze , A.M. Esetov
Keyword(s):  
Spina Bifida ◽  
Choroid Plexus ◽  
Prospective Studies ◽  
Third Ventricle ◽  
Fetal Brain ◽  
First Trimester ◽  
Axial Plane ◽  
Ultrasound Screening ◽  
Retrospective Assessment

Results of retrospective assessment of the choroid plexus pattern obtained from 17 fetuses with open spinal defects during ultrasound screening between 11 and 13 weeks of gestation are presented. To obtain the picture of the “butterfly” sign conducted a study of the axial plane of the fetal brain at the level of roof third ventricle with a correction of verticality. The absence of a typical “butterfly” picture is noted in all fetuses with spina bifida at 11–14 weeks of gestation. Prospective studies are needed to assess the effectiveness of the choroid plexus picture change for screening in the first trimester.

scholarly journals Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Stephanie Antoun ◽  
Pierre Ellul ◽  
Hugo Peyre ◽  
Michelle Rosenzwajg ◽  
Pierre Gressens ◽  
...  
Keyword(s):  
Systematic Review ◽  
Risk Factor ◽  
Random Effects ◽  
Neurodevelopmental Disorders ◽  
Meta Analysis ◽  
Fetal Brain ◽  
First Trimester ◽  
Case Control ◽  
Increased Risk ◽  
The Impact

Abstract Background Fever during pregnancy is a relatively common and most often trivial event. However, under specific conditions, it could affect significantly fetal brain development. Few studies, with inconsistent results, investigated whether fever, regardless the pathogen, could represent a risk factor for neurodevelopmental disorders (NDD) in the offspring. We aimed to explore further this question by performing a systematic review and meta-analysis. Methods Peer-reviewed studies exploring the occurrence of NDD in offspring after a fetal exposure to maternal fever were included. We specifically considered the impact of fever severity and duration, taking into consideration some confounding variables such as the use of antipyretic during pregnancy, the trimester in which the fever arose, the maternal age or smoking at time of gestation. MEDLINE, EMBASE, PsycINFO, Cochrane and Web of Science were searched without language restriction. PRISMA recommendations were followed. Odds ratio (OR) were pooled using random-effects meta-analysis. Heterogeneity in effect size across studies was studied using random-effects meta-regression analysis. (PROSPERO CRD42020182801). Results We finally considered ten studies gathering a total of 10,304 children with NDD. Among them, 1394 were exposed to fever during pregnancy. The selected studies were divided into 5 case–control studies and 5 cohort studies. Maternal exposure to fever during pregnancy increased the risk of NDD in offspring with an OR of 1.24 [95% CI: 1.12–1.38]. Secondary analysis revealed an increased risk for NDD when fever occurred during the first trimester of gestation [OR 1.13–95% CI: 1.02–1.26]. Limitations We excluded studies that considered infections with no evidence of fever. Another potential limitation may be the possible heterogeneity between study designs (cohorts and case–control). Conclusion Additional evidence supported the association between fever during pregnancy and increased risk for NDD in offspring. Careful monitoring should be considered for children born from mothers with a febrile episode during pregnancy (specifically during the first trimester).

Magnetic resonance imaging and the detection of fetal brain anomalies, injury, and physiologic adaptations

2006 ◽  
Vol 18 (2) ◽  
pp. 164-176 ◽  
Author(s):  
Nadine Girard ◽  
Kathia Chaumoitre ◽  
Sylvianne Confort-Gouny ◽  
Angele Viola ◽  
Olivier Levrier
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fetal Brain ◽  
Resonance Imaging ◽  
Brain Anomalies

scholarly journals Central Nervous System Anomalies Detectable in the First Trimester

2017 ◽  
Vol 11 (4) ◽  
pp. 261-267
Author(s):  
Elsa Viora ◽  
Giulia Polarolo ◽  
Simona Bastonero ◽  
Elena Gullino ◽  
Silvia Stillavato ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pregnancy Termination ◽  
Fetal Brain ◽  
First Trimester ◽  
Ultrasound Images ◽  
Agenesis Of Corpus Callosum ◽  
Ultrasound Findings ◽  
Fetal Brain Development ◽  
Central Nervous System Anomalies

ABSTRACT Prenatal diagnosis of central nervous system (CNS) congenital anomalies is possible in the second and third trimester. Earlier diagnosis is possible for some of these as the complex acranial/exencephaly/anencephaly and alobar holoprosencephaly (HPE). The knowledge of normal fetal brain development and its ultrasound images at the different weeks’ gestation, the expertise of operators, and high-resolution equipment are essential to obtain good results. The diagnosis in the first trimester of some major anomalies incompatible with extrauterine life or associated with severe handicap is useful to inform the couple, to perform additional examinations, and provide them with the option of earlier and safer pregnancy termination. For some other conditions, like agenesis of corpus callosum and hypoplasia or absence of cerebellar vermis, the diagnosis is possible only in the second trimester, so beware not to falsely reassure or scare expecting parents. In conclusion, first trimester ultrasound could be useful for early detection of some CNS anomalies, but caution could be used for others, particularly in counseling couples about prognostic significant of ultrasound findings. How to cite this article Viora E, Polarolo G, Bastonero S, Gullino E, Stillavato S, Sciarrone A. Central Nervous System Anomalies Detectable in the First Trimester. Donald School J Ultrasound Obstet Gynecol 2017;11(4):261-267.

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