scholarly journals P19.10: Cardiac dysfunction in TTTS donor and recipient twins: same effect on myocardial performance index time intervals?

2017 ◽  
Vol 50 ◽  
pp. 217-217
Author(s):  
J.U. Ortiz ◽  
X. Torres ◽  
E. Eixarch ◽  
M. Bennasar ◽  
M. Cruz Lemini ◽  
...  
Keyword(s):  
Cardiac Dysfunction ◽  
Performance Index ◽  
Myocardial Performance Index ◽  
Myocardial Performance ◽  
Time Intervals

Third Trimester Myocardial Performance Index in Fetuses from Women with Hyperglycemia in Pregnancy: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Angelo Sirico ◽  
Antonio Raffone ◽  
Giuseppe Maria Maruotti ◽  
Antonio Travaglino ◽  
Carmela Paciullo ◽  
...  
Keyword(s):  
Subgroup Analysis ◽  
Cardiac Dysfunction ◽  
Performance Index ◽  
Myocardial Performance Index ◽  
Control Group ◽  
Healthy Controls ◽  
Myocardial Performance ◽  
Third Trimester ◽  
Potential Marker ◽  
In Pregnancy

Abstract Introduction The myocardial performance index (MPI) has been proposed to evaluate cardiac dysfunction in newborns from diabetic mothers. Although MPI is routinely assessed in newborns, its role in the evaluation of fetuses from women with hyperglycemia in pregnancy (HIP) is still under evaluation. We aimed to evaluate the differences in third trimester fetal MPI in pregnant women with hyperglycemia compared to healthy controls. Materials and Methods Seven electronic databases were searched for all studies assessing women with HIP who underwent evaluation of fetal left MPI during pregnancy compared to a control group. The summary measures were reported as mean differences (MD) in the mean fetal left MPI between women with HIP and healthy controls, with a 95 % confidence interval (CI). A post hoc subgroup analysis based on the type of HIP – pregestational diabetes, GDM, or gestational impaired glucose tolerance (GIGT) – was performed as an additional analysis. Results 14 studies assessing 1326 fetuses (580 from women with HIP and 746 from controls) were included. Women with HIP had a significantly higher mean left fetal MPI compared to controls (MD 0.08; 95 %CI: 0.05 to 0.11; p < 0.00 001). Subgroup analysis according to the type of HIP concurred with the overall analysis for women with DM (MD 0.07; 95 %CI: 0.01 to 0.13; p = 0.02) and for women with GDM (MD 0.012; 95 %CI: 0.07 to 0.17; p < 0.00 001) but not for women with GIGT (MD –0.01, 95 % CI –0.28 to 0.27; p = 0.96). Conclusion Fetal left MPI is increased in pregnancies with HIP appearing as a potential marker of cardiac dysfunction.

Partial deletion of ROCK2 protects mice from high-fat diet-induced cardiac insulin resistance and contractile dysfunction

2015 ◽  
Vol 309 (1) ◽  
pp. H70-H81 ◽  
Author(s):  
Hesham Soliman ◽  
Vongai Nyamandi ◽  
Marysol Garcia-Patino ◽  
Julia Nogueira Varela ◽  
Girish Bankar ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cardiac Dysfunction ◽  
Performance Index ◽  
High Fat Diet ◽  
Left Ventricular ◽  
Myocardial Performance Index ◽  
Contractile Dysfunction ◽  
Myocardial Performance ◽  
High Fat ◽  
Glut4 Expression

Obesity is associated with cardiac insulin resistance and contractile dysfunction, which contribute to the development of heart failure. The RhoA-Rho kinase (ROCK) pathway has been reported to modulate insulin resistance, but whether it is implicated in obesity-induced cardiac dysfunction is not known. To test this, wild-type (WT) and ROCK2+/− mice were fed normal chow or a high-fat diet (HFD) for 17 wk. Whole body insulin resistance, determined by an insulin tolerance test, was observed in HFD-WT, but not HFD-ROCK2+/−, mice. The echocardiographically determined myocardial performance index, a measure of global systolic and diastolic function, was significantly increased in HFD-WT mice, indicating a deterioration of cardiac function. However, no change in myocardial performance index was found in hearts from HFD-ROCK2+/− mice. Speckle-tracking-based strain echocardiography also revealed regional impairment in left ventricular wall motion in hearts from HFD-WT, but not HFD-ROCK2+/−, mice. Activity of ROCK1 and ROCK2 was significantly increased in hearts from HFD-WT mice, and GLUT4 expression was significantly reduced. Insulin-induced phosphorylation of insulin receptor substrate (IRS) Tyr612, Akt, and AS160 was also impaired in these hearts, while Ser307 phosphorylation of IRS was increased. In contrast, the increase in ROCK2, but not ROCK1, activity was prevented in hearts from HFD-ROCK2+/− mice, and cardiac levels of TNFα were reduced. This was associated with normalization of IRS phosphorylation, downstream insulin signaling, and GLUT4 expression. These data suggest that increased activation of ROCK2 contributes to obesity-induced cardiac dysfunction and insulin resistance and that inhibition of ROCK2 may constitute a novel approach to treat this condition.

Time intervals and myocardial performance index by tissue Doppler imaging

2010 ◽  
Vol 6 (5) ◽  
pp. 393-402 ◽  
Author(s):  
Michele Correale ◽  
Antonio Totaro ◽  
Riccardo Ieva ◽  
Natale Daniele Brunetti ◽  
Matteo Di Biase
Keyword(s):  
Tissue Doppler Imaging ◽  
Performance Index ◽  
Tissue Doppler ◽  
Myocardial Performance Index ◽  
Doppler Imaging ◽  
Myocardial Performance ◽  
Time Intervals

scholarly journals Cardiac time intervals and myocardial performance index for prediction of twin‐twin transfusion syndrome

2021 ◽  
Author(s):  
Manon. Gijtenbeek ◽  
Sanne J. Eschbach ◽  
Johanna M. Middeldorp ◽  
Frans J.C.M. Klumper ◽  
F. Slaghekke ◽  
...  
Keyword(s):  
Performance Index ◽  
Myocardial Performance Index ◽  
Myocardial Performance ◽  
Time Intervals ◽  
Cardiac Time Intervals

Myocardial performance index by tissue Doppler echocardiography predicts adverse events in patients with atrial fibrillation

2019 ◽  
Vol 21 (5) ◽  
pp. 560-566 ◽  
Author(s):  
Maria Dons ◽  
Flemming Javier Olsen ◽  
Martina Chantal de Knegt ◽  
Thomas Fritz-Hansen ◽  
Rasmus Mogelvang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Performance Index ◽  
Prognostic Value ◽  
Independent Predictor ◽  
Tissue Doppler ◽  
Myocardial Performance Index ◽  
Left Ventricular Ejection ◽  
Myocardial Performance ◽  
Time Intervals ◽  
Increased Risk

Abstract Aims  The prognostic value of myocardial performance index (MPI) has not yet been assessed in patients with atrial fibrillation (AF). The aim of this study was to evaluate the prognostic value of MPI by tissue Doppler imaging (TDI) M-mode in AF patients. Methods and results  Echocardiograms from 210 patients with AF during examination were analysed offline. Patients with known heart failure (HF) were excluded. Time intervals were measured using an M-mode line through the mitral valve leaflets to provide a colour diagram of the mitral leaflet movement so all time intervals could be measured from one cardiac cycle. MPI was calculated as the sum of isovolumic relaxation time and isovolumic contraction time divided by the ejection time [(IVRT+IVCT)/ET]. During a median follow-up of 2.4 years, 84 patients (40%) reached the combined endpoint of major adverse cardiovascular events (MACE), being all-cause mortality, HF, myocardial infarction, or stroke. Increasing MPI was significantly associated with an increased risk of MACE, and the risk increased with 20% per 0.1 increase in MPI [hazard ratio (HR) 1.20, 95% confidence interval (CI) 1.10–1.32; P &lt; 0.001]. Increasing MPI was also significantly associated with a lower left ventricular ejection fraction (LVEF) (P &lt; 0.001). Nevertheless, MPI remained an independent predictor even after adjustment for age, sex, diabetes mellitus, left atrial volume, and LVEF (HR 1.12, 95% CI 1.01–1.25; P = 0.038). Conclusion  Increasing MPI was significantly associated with increased risk of MACE and remained an independent predictor after multivariable adjustment. This demonstrates that the MPI obtained by TDI M-mode might be useful in assessing cardiac function in AF patients with ongoing arrhythmia during examination.

scholarly journals The Fetal Modified Myocardial Performance Index: Is Automation the Future?

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Priya Maheshwari ◽  
Amanda Henry ◽  
Alec W. Welsh
Keyword(s):  
Performance Index ◽  
Left Ventricular ◽  
Myocardial Performance Index ◽  
Time Interval ◽  
Reference Ranges ◽  
Myocardial Performance ◽  
Time Intervals ◽  
Measurement Variability ◽  
Cardiac Time Intervals ◽  
The Future

The fetal modified myocardial performance index (Mod-MPI) is a noninvasive, pulsed-wave Doppler-derived measure of global myocardial function. This review assesses the progress in technical refinements of its measurement and the potential for automation to be the crucial next step. The Mod-MPI is a ratio of isovolumetric to ejection time cardiac time intervals, and the potential for the left ventricular Mod-MPI as a tool to clinically assess fetal cardiac function is well-established. However, there are wide variations in published reference ranges, as (1) a standardised method of selecting cardiac time intervals used in Mod-MPI calculation has not been established; (2) cardiac time interval measurement currently requires manual, inherently subjective placement of callipers on Doppler ultrasound waveforms; and (3) ultrasound machine settings and ultrasound system type have been found to affect Mod-MPI measurement. Collectively these factors create potential for significant inter- and intraobserver measurement variability. Automated measurement of the Mod-MPI may be the next key development which propels the Mod-MPI into routine clinical use. A novel automated system of Mod-MPI measurement is briefly presented and its implications for the future of the Mod-MPI in fetal cardiology are discussed.

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