scholarly journals OC05.02: Fetal urine biochemistry in prediction of long-term (10-30 years of age) postnatal renal function in posterior urethral valves

2017 ◽  
Vol 50 ◽  
pp. 9-9
Author(s):  
S. Dreux ◽  
A. Moussy-Durandy ◽  
F. Patin ◽  
R. Favre ◽  
S. Lortat-Jacob ◽  
...  
Keyword(s):  
Renal Function ◽  
Posterior Urethral Valves ◽  
Urethral Valves ◽  
Fetal Urine ◽  
Urine Biochemistry

Long-Term Renal Function in the Posterior Urethral Valves, Unilateral Reflux and Renal Dysplasia Syndrome

1997 ◽  
Vol 158 (3) ◽  
pp. 1004-1007 ◽  
Author(s):  
Peter M. Cuckow ◽  
M.D. Dinneen ◽  
R.A. Risdon ◽  
P.G. Ransley ◽  
P.G. Duffy
Keyword(s):  
Renal Function ◽  
Renal Dysplasia ◽  
Posterior Urethral Valves ◽  
Urethral Valves

scholarly journals LONG-TERM BLADDER DYSFUNCTION AND RENAL FUNCTION IN BOYS WITH POSTERIOR URETHRAL VALVES BASED ON URODYNAMIC FINDINGS

2004 ◽  
Vol 171 (6 Part 1) ◽  
pp. 2409-2412 ◽  
Author(s):  
MAZEN A. GHANEM ◽  
KATJA P. WOLFFENBUTTEL ◽  
ANN DE VYLDER ◽  
RIEN J.M. NIJMAN
Keyword(s):  
Renal Function ◽  
Bladder Dysfunction ◽  
Posterior Urethral Valves ◽  
Urethral Valves

Urine biochemistry to predict long-term outcomes in fetuses with posterior urethral valves

2018 ◽  
Vol 38 (12) ◽  
pp. 964-970 ◽  
Author(s):  
Sophie Dreux ◽  
Jonathan Rosenblatt ◽  
Amélie Moussy-Durandy ◽  
Franck Patin ◽  
Romain Favre ◽  
...  
Keyword(s):  
Posterior Urethral Valves ◽  
Long Term Outcomes ◽  
Urethral Valves ◽  
Urine Biochemistry

Long-Term Renal Function in the Posterior Urethral Valves, Unilateral Reflux and Renal Dysplasia Syndrome

1997 ◽  
pp. 1004-1007 ◽  
Author(s):  
Peter M. Cuckow ◽  
M. D. Dinneen ◽  
R. A. Risdon ◽  
P. G. Ransley ◽  
P. G. Duffy
Keyword(s):  
Renal Function ◽  
Renal Dysplasia ◽  
Posterior Urethral Valves ◽  
Urethral Valves

674: Long-Term Renal Function in Patients with Posterior Urethral Valves

2004 ◽  
Vol 171 (4S) ◽  
pp. 179-179
Author(s):  
C.D. Anthony Herndon ◽  
Anthony Casale ◽  
Brian Benway ◽  
Martin Kaefer ◽  
Mark P. Cain ◽  
...  
Keyword(s):  
Renal Function ◽  
Posterior Urethral Valves ◽  
Urethral Valves

Posterior Urethral Valves: Long-term Renal Function Consequences After Transplantation

1997 ◽  
Vol 157 (3) ◽  
pp. 992-995 ◽  
Author(s):  
Laurent Salomon ◽  
Eric Fontaine ◽  
Marie-France Gagnadoux ◽  
Michel Broyer ◽  
Daniel Beurton
Keyword(s):  
Renal Function ◽  
Posterior Urethral Valves ◽  
Urethral Valves

scholarly journals The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design

2019 ◽  
Vol 13 (3) ◽  
pp. 371-379 ◽  
Author(s):  
Bénédicte Buffin-Meyer ◽  
Julie Klein ◽  
Loes F M van der Zanden ◽  
Elena Levtchenko ◽  
Panogiotis Moulos ◽  
...  
Keyword(s):  
Renal Function ◽  
Multicentre Study ◽  
Kidney Diseases ◽  
Posterior Urethral Valves ◽  
Renal Outcome ◽  
Fetal Ultrasound ◽  
Urethral Valves ◽  
Fetal Urine ◽  
Urological Disorders ◽  
Stage Renal Disease

Abstract Background Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management of PUV is prenatal prediction of postnatal renal function. Fetal ultrasound and fetal urine biochemistry are currently employed for this prediction, but clearly lack precision. We previously developed a fetal urine peptide signature that predicted in utero with high precision postnatal renal function in fetuses with PUV. We describe here the objectives and design of the prospective international multicentre ANTENATAL (multicentre validation of a fetal urine peptidome-based classifier to predict postnatal renal function in posterior urethral valves) study, set up to validate this fetal urine peptide signature. Methods Participants will be PUV pregnancies enrolled from 2017 to 2021 and followed up until 2023 in >30 European centres endorsed and supported by European reference networks for rare urological disorders (ERN eUROGEN) and rare kidney diseases (ERN ERKNet). The endpoint will be renal/patient survival at 2 years postnatally. Assuming α = 0.05, 1–β = 0.8 and a mean prevalence of severe renal outcome in PUV individuals of 0.35, 400 patients need to be enrolled to validate the previously reported sensitivity and specificity of the peptide signature. Results In this largest multicentre study of antenatally detected PUV, we anticipate bringing a novel tool to the clinic. Based on urinary peptides and potentially amended in the future with additional omics traits, this tool will be able to precisely quantify postnatal renal survival in PUV pregnancies. The main limitation of the employed approach is the need for specialized equipment. Conclusions Accurate risk assessment in the prenatal period should strongly improve the management of fetuses with PUV.

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