EP05.06: Role of Doppler velocimetry in prediction of adverse pregnancy outcome in fetal growth restriction

2015 ◽  
Vol 46 ◽  
pp. 199-199
Author(s):  
A. Jamal ◽  
S. Kashi ◽  
V. Marsoosi ◽  
L. Eslamian
Keyword(s):  
Pregnancy Outcome ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Adverse Pregnancy Outcome ◽  
Growth Restriction ◽  
Doppler Velocimetry ◽  
Adverse Pregnancy

scholarly journals Thrombophilias and adverse pregnancy outcome – A confounded problem!

2008 ◽  
Vol 99 (01) ◽  
pp. 77-85 ◽  
Author(s):  
Nard G Janssen ◽  
Jakoba J Kalk ◽  
William M Hague ◽  
Gustaaf A Dekker ◽  
Willem J Kist ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Adverse Pregnancy Outcome ◽  
Fetal Loss ◽  
Severity Of Illness ◽  
Growth Restriction ◽  
Abruptio Placentae ◽  
Recurrent Fetal Loss ◽  
Adverse Pregnancy

SummaryIt was the objective of this study to analyse the influence of confounders, such as ethnicity, severity of illness and method of testing, in articles concerning the still moot relationship of thrombophilias to adverse pregnancy outcome (APO). Relevant casecontrol studies were identified using Medline and EMBASE databases between 1966 and 2006. Search terms were recurrent fetal loss, intrauterine fetal death, preeclampsia, HELLP-syndrome, eclampsia, fetal growth restriction, abruptio placentae, combined with maternal thrombophilias. Data was extracted from the articles per subgroup ofAPO regardless of confounder. These subgroups were tested if they fulfilled the heterogeneity testing criterion (I2 > 35%) to weigh the influence of the confounder. Confounders were selected and examined with Mantel- Haenszel method. Increased thrombophilia prevalence was confirmed in most adverse pregnancy outcomes. Ethnicity, genetic testing only and severity of illness were confounders in the various forms of APO. Stronger relationships between factor V Leiden and severity of disease were found in 2nd and 3rd trimester than 1st trimester recurrent fetal loss, in preeclampsia with: blood pressure ≥160/110 mmHg than ≥140/90 mmHg; proteinuria ≥5 grams per day than < 5 grams; onset before than after 28 weeks, in fetal growth restriction <3rd percentile than <5th, than <10th, and in earlier occurrence of abruptio placentae than 3rd trimester. In conclusion, reports on the prevalence of maternal thrombophilias and APO are influenced by various confounders, which are not always appropriately analysed. The differences we have identified reflect the differential impact of these confounders. These data emphasise the importance of more uniform research.

scholarly journals The Role of Placental Homeobox Genes in Human Fetal Growth Restriction

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Padma Murthi ◽  
Gayathri Rajaraman ◽  
Shaun Patrick Brennecke ◽  
Bill Kalionis
Keyword(s):  
Pregnancy Outcome ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Transcriptional Control ◽  
Molecular Mechanisms ◽  
Adverse Pregnancy Outcome ◽  
Growth Restriction ◽  
Placental Development ◽  
Increased Risk ◽  
Adverse Pregnancy

Fetal growth restriction (FGR) is an adverse pregnancy outcome associated with significant perinatal and paediatric morbidity and mortality, and an increased risk of chronic disease later in adult life. One of the key causes of adverse pregnancy outcome is fetal growth restriction (FGR). While a number of maternal, fetal, and environmental factors are known causes of FGR, the majority of FGR cases remain idiopathic. These idiopathic FGR pregnancies are frequently associated with placental insufficiency, possibly as a result of placental maldevelopment. Understanding the molecular mechanisms of abnormal placental development in idiopathic FGR is, therefore, of increasing importance. Here, we review our understanding of transcriptional control of normal placental development and abnormal placental development associated with human idiopathic FGR. We also assess the potential for understanding transcriptional control as a means for revealing new molecular targets for the detection, diagnosis, and clinical management of idiopathic FGR.

Ultrasound biometry and fetal growth restriction

2002 ◽  
Vol 13 (4) ◽  
pp. 249-259 ◽  
Author(s):  
Jason Gardosi
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Umbilical Artery ◽  
Adverse Outcome ◽  
Growth Restriction ◽  
Doppler Velocimetry ◽  
Doppler Flow ◽  
Biophysical Profile ◽  
Flow Velocimetry

With the ascendancy of biophysical assessment with Doppler velocimetry, and the establishment of routine scan dating in early pregnancy, there needs to be a radical re-think of the role of ultrasound biometry in the definition and assessment of fetal growth restriction (FGR).Doppler flow velocimetry of the umbilical artery has proven its value in defining the FGR fetus. It is more useful than cardiotocography (CTG) or biophysical profile scoring. However, the sensitivity of any test depends on the prevalence of the condition being looked for. While Doppler is of value in fetuses which are small-for-gestational age (SGA), it is less useful in predicting growth restriction or adverse outcome in the general population. The question is therefore, how to detect those pregnancies for which further fetal assessment is indicated.

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