scholarly journals OC11.01: Fetal hemodynamic assessment by MRI for detecting late-onset intrauterine growth restriction (IUGR)

2015 ◽  
Vol 46 ◽  
pp. 23-23
Author(s):  
M. Zhu ◽  
S. Keating ◽  
N. Milligan ◽  
R. Windrim ◽  
S. Portnoy ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Late Onset ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Hemodynamic Assessment

Early functional and morphological brain disturbances in late-onset intrauterine growth restriction

2016 ◽  
Vol 93 ◽  
pp. 33-38 ◽  
Author(s):  
Mirta Starčević ◽  
Maja Predojević ◽  
Dražan Butorac ◽  
Jasna Tumbri ◽  
Paško Konjevoda ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Late Onset ◽  
Growth Restriction ◽  
Intrauterine Growth

Placental HIF-1α, HIF-2α, membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine growth restriction

2007 ◽  
Vol 293 (2) ◽  
pp. R766-R774 ◽  
Author(s):  
Augustine Rajakumar ◽  
Arun Jeyabalan ◽  
Nina Markovic ◽  
Roberta Ness ◽  
Carol Gilmour ◽  
...  
Keyword(s):  
Northern Blot ◽  
Intrauterine Growth Restriction ◽  
Northern Blot Analysis ◽  
Late Onset ◽  
Growth Restriction ◽  
Trophoblast Invasion ◽  
Vegf Receptor ◽  
Placental Perfusion ◽  
Intrauterine Growth ◽  
Factor Α

Inadequate trophoblast invasion and spiral artery remodeling leading to poor placental perfusion are believed to underlie the pregnancy pathologies preeclampsia (PE) and intrauterine growth restriction (IUGR). The main objective of this study was to investigate hypoxia-inducible transcription factor-α (HIF-α) and downstream genes (VEGF receptor-1) Flt-1 and soluble fms-like tyrosine kinase 1 (sFlt-1) proteins in IUGR placentas. Placentas from normal pregnant (NP; n = 18), PE ( n = 18), and IUGR ( n = 10) patients were investigated. Normotensive patients with IUGR delivered babies at ≥ 37 wk of gestation with birth weights of <10% and asymmetrical growth. HIF-1α, -2α, Flt-1, and sFlt-1 protein, and mRNA were assessed by Western and Northern blot analyses, respectively. The results are expressed as ratios of the densitometric values for each pair of pathologic and normal placentas, a ratio of 1.0 indicating no difference. Comparable to our earlier studies, the PE/NP ratios for HIF-1α, -2α, and Flt proteins were significantly increased by 50–100% (all P < 0.01 vs. 1.0). Unexpectedly, the IUGR/NP ratios for HIF-1α and -2α proteins were 1.03 ± 0.07 and 0.96 ± 0.16, respectively, and for Flt and sFlt were 1.14 ± 0.15 and 0.95 ± 0.12, respectively (all P = not significant vs. 1.0). Northern blot analysis revealed comparable levels of HIF-α mRNA in abnormal and normal placentas. In contrast to PE, HIF-α proteins and regulated genes are not increased in placentas from normotensive pregnant women delivering small, asymmetrically grown babies ≥ 37 wk of gestation. The absence of an increase in HIF-α protein is not due to insufficient HIF-α mRNA for protein synthesis. Thus, the placentas from women with PE and late IUGR are fundamentally different at the molecular level.

scholarly journals The value of DNA methylation profiling in characterizing preeclampsia and intrauterine growth restriction

2017 ◽  
Author(s):  
Samantha L Wilson ◽  
Katherine Leavey ◽  
Brian Cox ◽  
Wendy P Robinson
Keyword(s):  
Dna Methylation ◽  
Intrauterine Growth Restriction ◽  
Late Onset ◽  
Growth Restriction ◽  
Hypertensive Disorder ◽  
Intrauterine Growth ◽  
Healthy Pregnancy ◽  
Genome Wide ◽  
Illumina Humanmethylation450 ◽  
Clinical Diagnoses

AbstractPlacental health is a key component to healthy pregnancy. Placental insufficiency (PI), inadequate nutrient delivery to the fetus, is associated with preeclampsia (PE), a maternal hypertensive disorder, and intrauterine growth restriction (IUGR), pathologically poor fetal growth. PI is more common in early-onset PE (EOPE) than late-onset PE (LOPE). However, the relationship between these disorders remains unclear. While DNA methylation (DNAm) alterations have been identified in PE and IUGR, these entities can overlap and few studies have analyzed these separately. This study aims to identify altered DNAm in EOPE, LOPE, and normotensive IUGR, validate these alterations, and use them to better understand the relationships between these related disorders.Placental samples from a discovery cohort (43 controls, 22 EOPE, 18 LOPE, 11 IUGR) and validation cohort (15 controls, 22 EOPE, 11 LOPE) were evaluated using the Illumina HumanMethylation450 array. To minimize gestational age (GA) effects, EOPE samples were compared to pre-term controls (GA <37 weeks), while LOPE and IUGR were compared to term controls (GA >37 weeks). There were 1703 differentially methylated (DM) sites (FDR<0.05, Δβ>0.1) in EOPE, 5 in LOPE, and 0 in IUGR. Of the 1703 EOPE sites, 599 were validated in the second cohort. These sites cluster samples from both cohorts into 3 distinct methylation clusters. Interestingly, LOPE samples diagnosed between 34-36 weeks with co-occurring IUGR clustered with the EOPE methylation cluster. DNAm profiling may provide an independent tool to refine clinical diagnoses into subgroups with more uniform pathology. The challenges in reproducing genome-wide DNAm studies are also discussed.

NT-proBNP levels in preeclampsia, intrauterine growth restriction as well as in the prediction on an imminent delivery

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Paula Lafuente-Ganuza ◽  
Fran Carretero ◽  
Paloma Lequerica-Fernández ◽  
Ana Fernandez-Bernardo ◽  
Ana I. Escudero ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Early Onset ◽  
Intrauterine Growth Restriction ◽  
Left Atrial ◽  
Late Onset ◽  
Growth Restriction ◽  
Low Cardiac Output ◽  
Intrauterine Growth ◽  
High Positive Predictive Value ◽  
Early Onset Preeclampsia

Abstract Objectives Studies of cardiovascular function in pregnancy have shown inconsistent and, in some cases, contradictory results, particularly regarding cardiac output. While some studies report preeclampsia associated with high cardiac output, other studies suggest that preeclampsia should be further subdivided into women with high or low cardiac output. This study was conducted to examine the NT-proBNP levels in preeclampsia, intrauterine growth restriction, and hypertensive pregnancies without preeclampsia. We also examined N-terminal pro-B natriuretic peptide (NT-proBNP) levels three to four months after delivery, in preeclamptic women as well as the prediction of delivery within 10 days. In a reduced number of preeclamptic women and controls we performed echocardiograms to study their diastolic function. Methods We investigated the NT-proBNP levels in 213 subjects with preeclampsia only, 73 with intrauterine growth restriction, 44 with preeclampsia and intrauterine growth restriction, 211 who were hypertensive and 662 unaffected pregnancies (controls). We also performed echocardiograms on 36 preeclampsia and 19 controls before delivery and three to five months after delivery. Results NT-proBNP levels are higher in early onset preeclampsia than in late onset preeclampsia. Intrauterine growth restriction pregnancies showed a NT-proBNP levels similar to hypertensive and unaffected pregnancies. Compared with healthy pregnancies, women with preterm preeclampsia (<37 gestational weeks) had altered left atrial segments. Conclusions We observed that NT-proBNP levels are higher in early onset preeclampsia than in late onset. Moreover, diastolic dysfunction is higher in early onset than in late-onset term preeclampsia. An NT-proBNP value >136 pg/mL has a high positive predictive value for an imminent delivery within 10 days.

The hemodynamics of late-onset intrauterine growth restriction by MRI

2016 ◽  
Vol 214 (3) ◽  
pp. 367.e1-367.e17 ◽  
Author(s):  
Meng Yuan Zhu ◽  
Natasha Milligan ◽  
Sarah Keating ◽  
Rory Windrim ◽  
Johannes Keunen ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Late Onset ◽  
Growth Restriction ◽  
Intrauterine Growth

Oxidatively modified LDL particles in the human placenta in early and late onset intrauterine growth restriction

Placenta ◽  
2013 ◽  
Vol 34 (12) ◽  
pp. 1142-1149 ◽  
Author(s):  
U. Pecks ◽  
W. Rath ◽  
R. Caspers ◽  
K. Sosnowsky ◽  
B. Ziems ◽  
...  
Keyword(s):  
Human Placenta ◽  
Intrauterine Growth Restriction ◽  
Late Onset ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Modified Ldl ◽  
Ldl Particles ◽  
Oxidatively Modified
Sign in / Sign up

Export Citation Format

Share Document