scholarly journals P14.20: Impact of machine settings on 3DPD utero-placental indices in a pregnant sheep model with controlled uterine blood flow

2014 ◽  
Vol 44 (S1) ◽  
pp. 266-266
Author(s):  
O. Morel ◽  
J. Duan ◽  
E. Perdriolle-Galet ◽  
V. Tsatsaris ◽  
P. Chavatte-Palmer
Keyword(s):  
Blood Flow ◽  
Uterine Blood Flow ◽  
Sheep Model ◽  
Pregnant Sheep

Behavioral activity during prolonged hypoxemia in fetal sheep

1988 ◽  
Vol 65 (6) ◽  
pp. 2420-2426 ◽  
Author(s):  
A. D. Bocking ◽  
R. Gagnon ◽  
K. M. Milne ◽  
S. E. White
Keyword(s):  
Blood Flow ◽  
Eye Movements ◽  
Normal Incidence ◽  
Behavioral Activity ◽  
Uterine Blood Flow ◽  
Fetal Sheep ◽  
Pregnant Sheep ◽  
Fetal Breathing ◽  
Fetal Breathing Movements ◽  
Internal Iliac

Experiments were conducted in unanesthetized, chronically catheterized pregnant sheep to determine the fetal behavioral response to prolonged hypoxemia produced by restricting uterine blood flow. Uterine blood flow was reduced by adjusting a vascular occluder placed around the maternal common internal iliac artery to decrease fetal arterial O2 content from 6.1 +/- 0.3 to 4.1 +/- 0.3 ml/dl for 48 h. Associated with the decrease in fetal O2 content, there was a slight increase in fetal arterial PCO2 and decrease in pH, which were both transient. There was an initial inhibition of both fetal breathing movements and eye movements but no change in the pattern of electrocortical activity. After this initial inhibition there was a return to normal incidence of both fetal breathing movements and eye movements by 16 h of the prolonged hypoxemia. These studies indicate that the chronically catheterized sheep fetus is able to adapt behaviorally to a prolonged decrease in arterial O2 content secondary to the restriction of uterine blood flow.

The Effects of S(+)-Ketamine and Racemic Ketamine on Uterine Blood Flow in Chronically Instrumented Pregnant Sheep

2004 ◽  
pp. 497-502 ◽  
Author(s):  
Danja Str??mper ◽  
Wiebke Gogarten ◽  
Marcel E. Durieux ◽  
Kristian Hartleb ◽  
Hugo Van Aken ◽  
...  
Keyword(s):  
Blood Flow ◽  
Uterine Blood Flow ◽  
Pregnant Sheep ◽  
Racemic Ketamine

Effects of hyperthermia on uterine blood flow and shunting through uterine arteriovenous anastomoses in the late-pregnant ewe

1999 ◽  
Vol 11 (5) ◽  
pp. 201 ◽  
Author(s):  
Suzanne L. Miller ◽  
Graham Jenkin ◽  
David W. Walker
Keyword(s):  
Blood Flow ◽  
Experimental Period ◽  
Respiratory Alkalosis ◽  
Uterine Horn ◽  
Arteriovenous Anastomoses ◽  
Uterine Blood Flow ◽  
Ambient Conditions ◽  
Total Blood ◽  
Uterine Arteries ◽  
Pregnant Sheep

The effect of maternal hyperthermia on uterine blood flow (UBF) through the two main uterine arteries and on the proportion of UBF shunted through uterine arteriovenous anastomoses (AVAs) was investigated. Eight late-pregnant ewes were exposed to normothermic (22–23˚C) or hyperthermic (approx-imately 39˚C) ambient conditions for 8 h. UBF was measured in the left and right uterine arteries using flow probes and microspheres were injected into the uterine artery before, during and after the experimental period. The distribution of microspheres between the uterus and lungs was determined to calculate changes in capillary and AVA blood flows. Hyperthermia produced a significant (P<0.05) increase in maternal core temperature (+1.5˚C), increase in maternal blood pH (+0.21; P<0.05) and decrease in maternal pCO 2 (–16.2 mmHg; P<0.05). Blood flow to the uterine horn ipsilateral to the corpus luteum (CL) remained unchanged during hyperthermia, whereas total UBF and blood flow to the contralateral uterine horn were significantly decreased (P<0.05), by 23.1% and 20.8%, respectively, of pre-heat control values. The proportion of UBF shunted through uterine AVAs during hyperthermia was not significantly different from values observed in normothermic ewes (21.9 0.7%). Mild to moderate hyperthermia in late-pregnant sheep induces respiratory alkalosis and decreases total blood flow to the uterus, brought about by a decrease in blood flow to the uterine horn contralateral, but not ipsilateral to the CL. Heat treatment does not alter the proportion of UBF traversing uterine AVAs.

Oxygen, glucose, and lactate uptake by fetus and placenta during prolonged hypoxemia

1995 ◽  
Vol 268 (2) ◽  
pp. R303-R309 ◽  
Author(s):  
S. B. Hooper ◽  
D. W. Walker ◽  
R. Harding
Keyword(s):  
Blood Flow ◽  
Glucose Uptake ◽  
Lactate Clearance ◽  
Gravid Uterus ◽  
Uterine Blood Flow ◽  
Fetal Circulation ◽  
Umbilical Blood ◽  
Pregnant Sheep ◽  
Lactate Uptake ◽  
Arterial O2 Saturation

Our aim was to compare the effects of short (4 h) and prolonged (24 h) periods of reduced uterine blood flow (RUBF) on fetal and placental uptake of O2, glucose, and lactate. In pregnant sheep, uterine and umbilical blood flows were measured under normal conditions and after 4 and 24 h of RUBF. A 50% reduction in uterine blood flow caused a 56% reduction in fetal arterial O2 saturation (SaO2). Umbilical blood flow increased from 325 +/- 33 to 378 +/- 32 ml.min-1.kg-1 (P < 0.05) after 4 h but was not different from pre-RUBF values after 24 h. O2 uptake by the gravid uterus was not altered by RUBF, due to an increase (84%) in uterine O2 extraction. Similarly, uteroplacental and fetal O2 consumptions and fetal glucose uptake were not affected by RUBF, whereas uteroplacental glucose uptake was significantly reduced after 4 h (by 42%) and 24 h (by 58%) of RUBF. Fetal lactate uptake was greatly reduced from 78.7 +/- 15.5 to -167 +/- 57 mumol.min-1.kg-1 after 4 h and to -198 +/- 80 mumol.min-1.kg-1 after 24 h of RUBF; negative values indicate placental lactate uptake from the fetal circulation. Thus, although RUBF significantly reduced fetal SaO2, fetal and uteroplacental O2 consumptions did not change. In addition, although fetal glucose uptake was not altered by RUBF, during RUBF the placenta became a major site of lactate clearance from the fetal circulation.

scholarly journals Uterine blood flow responses to ICI 182 780 in ovariectomized oestradiol-17β-treated, intact follicular and pregnant sheep

2005 ◽  
Vol 565 (1) ◽  
pp. 71-83 ◽  
Author(s):  
Ronald R. Magness ◽  
Terrance M. Phernetton ◽  
Tiffini C. Gibson ◽  
Dong-bao Chen
Keyword(s):  
Blood Flow ◽  
Uterine Blood Flow ◽  
Pregnant Sheep

Distribution of uterine blood flow in the pregnant sheep

1968 ◽  
Vol 101 (3) ◽  
pp. 409-412 ◽  
Author(s):  
E.L. Makowski ◽  
G. Meschia ◽  
W. Droegemueller ◽  
F.C. Battaglia
Keyword(s):  
Blood Flow ◽  
Uterine Blood Flow ◽  
Pregnant Sheep

Effects of Cafedrine/Theodrenaline, Etilefrine and Ephedrine on Uterine Blood Flow during Epidural-Induced Hypotension in Pregnant Sheep

2005 ◽  
Vol 20 (5) ◽  
pp. 377-382 ◽  
Author(s):  
D. Strümper ◽  
W. Gogarten ◽  
M.E. Durieux ◽  
K. Hartleb ◽  
H. van Aken ◽  
...  
Keyword(s):  
Blood Flow ◽  
Uterine Blood Flow ◽  
Induced Hypotension ◽  
Pregnant Sheep
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