OC24.05: Fetal brain metabolism assessed by magnetic resonance spectroscopy in late onset “small-for-gestational age” versus “Intrauterine growth restriction”

2014 ◽  
Vol 44 (S1) ◽  
pp. 57-57
Author(s):  
M. Sanz-Cortes ◽  
R.V. Simoes ◽  
N. Bargallo ◽  
N. Masoller ◽  
F. Figueras ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Intrauterine Growth Restriction ◽  
Brain Metabolism ◽  
Late Onset ◽  
Fetal Brain ◽  
Resonance Spectroscopy ◽  
Intrauterine Growth

Proton Magnetic Resonance Spectroscopy Assessment of Fetal Brain Metabolism in Late-Onset ‘Small for Gestational Age' versus ‘Intrauterine Growth Restriction' Fetuses

2014 ◽  
Vol 37 (2) ◽  
pp. 108-116 ◽  
Author(s):  
Magdalena Sanz-Cortes ◽  
Rui V. Simoes ◽  
Nuria Bargallo ◽  
Narcis Masoller ◽  
Francesc Figueras ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Intrauterine Growth Restriction ◽  
Doppler Sonography ◽  
Late Onset ◽  
Resonance Spectroscopy ◽  
Intrauterine Growth ◽  
Estimated Fetal Weight

Objectives: We used magnetic resonance spectroscopy (MRS) to evaluate brain metabolic differences in small fetuses near term as compared to appropriate for gestational age (AGA) fetuses. Study Design: 71 term small fetuses (estimated fetal weight <10th centile for gestational age with normal umbilical artery Doppler sonography) were subclassified as late intrauterine growth restriction (IUGR) (n = 50) or small for gestational age (SGA) (n = 21), and compared with 65 AGA fetuses. IUGR was defined by either abnormal middle cerebral artery, abnormal uterine artery Doppler sonography or estimated fetal weight <3rd centile. All participants underwent brain magnetic resonance imaging at 37 weeks of gestation, and single-voxel magnetic resonance spectra were obtained from the frontal lobe on a 3-tesla scanner. N-acetylaspartate (NAA)/choline (Cho), NAA/creatine (Cr) and Cho/Cr ratios were calculated and compared between cases and controls. The association of the metabolic ratios with the study groups was tested. Results: After MRS processing and applying quality control criteria, 31 spectra from late-onset IUGR, 11 from SGA and 30 from AGA fetuses were selected for further analysis. Both SGA and late-onset IUGR fetuses showed significantly reduced NAA/Cho levels when compared to AGA fetuses. This decrease followed a linear trend across the three clinical groups that were considered. Conclusions: Both SGA and late-onset IUGR fetuses showed differences in MRS brain metabolic ratios. The findings suggest that despite near-normal perinatal outcomes, SGA fetuses are not constitutionally small and may represent a form of growth disorder that needs to be clarified.

scholarly journals Magnetic Resonance Spectroscopy: A Promise Detection of Metabolic Changes in the Brain of Intrauterine Growth Restriction Fetuses

2015 ◽  
Vol 9 (1) ◽  
pp. 40-43
Author(s):  
Radu Vladareanu ◽  
Vlad Zamfirescu
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Intrauterine Growth Restriction ◽  
Diffusion Mri ◽  
Metabolic Changes ◽  
Growth Restriction ◽  
Resonance Spectroscopy ◽  
Intrauterine Growth ◽  
Brain Reorganization ◽  
The Brain

ABSTRACT Technical and therapeutic advances have driven the development of fetal MRI, which is likely to become an increasingly important modality in the evaluation of sonographically complex or occult anomalies of the fetal brain and body. All radiologists involved in prenatal imaging should be aware of the applications and limitations of this modality. Magnetic resonance imaging (MRI) studies have consistently demonstrated brain structural changes on intrauterine growth restriction (IUGR). There is a need to improve MRI characterization of the anatomical patterns of brain reorganization associated with IUGR and to develop specific imaging biomarkers. Contrary to acute perinatal events, IUGR is a chronic condition that induces brain reorganization and abnormal maturation rather than gross tissue destruction. Diffusion MRI offers a promising approach to assess abnormalities in brain maturation and develop biomarkers for clinical use. The association between IUGR and short- and long-term neurodevelopmental and cognitive dysfunctions has been extensively described. Preliminary clinical results suggest that diffusion MRI could also be suitable to detect maturational changes occurring in chronic fetal conditions, including fetal cardiac defects and IUGR. How to cite this article Zamfirescu V, Vladareanu R, Vladareanu S. Magnetic Resonance Spectroscopy: A Promise for Detection of Metabolic Changes in the Brain of Intrauterine Growth Restriction Fetuses. Donald School J Ultrasound Obstet Gynecol 2015;9(1):40-43.

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