OC08.04: Fetal cardiac function in late IUGR versus SGA defined by estimated fetal weight, cerebro-placental ratio and uterine artery Doppler

2014 ◽  
Vol 44 (S1) ◽  
pp. 19-19 ◽  
Author(s):  
M. Pérez Cruz ◽  
F. Crispi ◽  
M. Fernández ◽  
J. Parra ◽  
M. Gómez Roig ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Uterine Artery ◽  
Fetal Weight ◽  
Uterine Artery Doppler ◽  
Fetal Cardiac Function ◽  
Estimated Fetal Weight

Maternal Cardiac Function and Uterine Artery Doppler at 11???14 Weeks in the Prediction of Preeclampsia in Nulliparous Women

2008 ◽  
Vol 63 (6) ◽  
pp. 347-348
Author(s):  
A Khaw ◽  
N A. Kametas ◽  
O M. Turan ◽  
J E. A. K. Bamfo ◽  
K H. Nicolaides
Keyword(s):  
Cardiac Function ◽  
Uterine Artery ◽  
Uterine Artery Doppler ◽  
Nulliparous Women

scholarly journals “Screening for small-for-gestational age neonates at early third trimester in a high-risk population for preeclampsia”

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Raquel Mula ◽  
Eva Meler ◽  
Sandra García ◽  
Gerard Albaigés ◽  
Bernat Serra ◽  
...  
Keyword(s):  
Growth Factor ◽  
High Risk ◽  
Biochemical Markers ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Placental Growth Factor ◽  
Fetal Weight ◽  
Third Trimester ◽  
Maternal Characteristics ◽  
Estimated Fetal Weight

Abstract Background Strategies to improve prenatal detection of small-for-gestational age (SGA) neonates are necessary because its association with poorer perinatal outcome. This study evaluated, in pregnancies with first trimester high risk of early preeclampsia, the performance of a third trimester screening for SGA combining biophysical and biochemical markers. Methods This is a prospective longitudinal study on 378 singleton pregnancies identified at high risk of early preeclampsia according to a first trimester multiparametric algorithm with the cutoff corresponding to 15% false positive rate. This cohort included 50 cases that delivered SGA neonates with birthweight < 10th centile (13.2%) and 328 cases with normal birthweight (86.8%). At 27–30 weeks’ gestation, maternal weight, blood pressure, estimated fetal weight, mean uterine artery pulsatility index and maternal biochemical markers (placental growth factor and soluble FMS-Like Tyrosine Kinase-1) were assessed. Different predictive models were created to evaluate their performance to predict SGA neonates. Results For a 15% FPR, a model that combines maternal characteristics, estimated fetal weight, mean uterine artery pulsatility index and placental growth factor achieved a detection rate (DR) of 56% with a negative predictive value of 92.2%. The area under receiver operating characteristic curve (AUC) was 0.79 (95% confidence interval (CI), 0.72–0.86). The DR of a model including maternal characteristics, estimated fetal weight and mean uterine artery pulsatility index was 54% (AUC, 0.77 (95% CI, 0.70–0.84)). The DR of a model that includes maternal characteristics and placental growth factor achieved a similar performance (DR 56%, AUC 0.75, 95% CI (0.67–0.83)). Conclusions The performance of screening for SGA neonates at early third trimester combining biophysical and biochemical markers in a high-risk population is poor. However, a high negative predictive value could help in reducing maternal anxiety, avoid iatrogenic interventions and propose a specific plan for higher risk patients.

scholarly journals Relationship Between Placental Calcification and Estimated Fetal Weight Percentile at 30-34 Weeks of Pregnancy

2019 ◽  
Vol 7 (4) ◽  
pp. 478-482
Author(s):  
Mojgan Barati ◽  
Sara Masihi ◽  
Elnaz Barahimi ◽  
Mohammad Ali Khorrami
Keyword(s):  
Pregnant Women ◽  
Uterine Artery ◽  
Adverse Pregnancy Outcome ◽  
Multiple Pregnancy ◽  
Cross Sectional Study ◽  
Fetal Weight ◽  
Cross Sectional ◽  
Adverse Pregnancy ◽  
Doppler Indices ◽  
Estimated Fetal Weight

Objectives: The identification of at-risk fetus is considered as one of the most difficult challenges for clinicians and researchers although the clinical significance of placental calcifications (PCs) and its relation to adverse pregnancy outcome are controversial. Therefore, the present study aimed to evaluate the relationship between PC and estimated fetal weight (EFW) percentile at 30-34 weeks of pregnancy. Materials and Methods: This prospective cross-sectional study was carried out on all pregnant women except for multiple pregnancy subjects who were admitted to an outpatient perinatal center from October 2016 to September 2018. Several parameters were measured at 30-34 weeks of pregnancy, including EFW, umbilical artery pulsatility index (PI), middle cerebral artery PI, cerebroplacental ratio (CPR), right and left uterine artery PI, along with right and left uterine artery notch. Finally, the calcification of the placenta with any shape and degree was determined as well. Results: In this study, 739 pregnant women were evaluated for PC, including patients with PC (9.87%), small-for-gestational age (SGA, 3.65%), and those with at least one abnormal Doppler index (23.95%). Patients with PC and those with at least one abnormal Doppler index had significantly higher SGA (29.62% and 12.42%, respectively). In addition, there were 55.55% and 30.13% patients with SGA and PC in the group with at least one abnormality in terms of Doppler indices. Conclusions: In general, the findings showed that PC is more common in SGA. Based on the results, at least one abnormality in Doppler indices was more common in PC and SGA, and uterine artery Doppler abnormality was the most prevalent abnormal findings in the arterial Doppler. Thus, PC may be an important marker for adverse pregnancy outcomes.

scholarly journals Echocardiographic assessment of fetal cardiac function in the uterine artery ligation rat model of IUGR

2021 ◽  
Author(s):  
Yichen Dai ◽  
Dan Zhao ◽  
Ching Kit Chen ◽  
Choon Hwai Yap
Keyword(s):  
Cardiac Function ◽  
Rat Model ◽  
Cardiac Dysfunction ◽  
Uterine Artery ◽  
Left Ventricular ◽  
Cardiovascular Physiology ◽  
Artery Ligation ◽  
Uterine Artery Ligation ◽  
Fetal Cardiac Function ◽  
Echocardiographic Assessment

Abstract Background Intrauterine growth restriction (IUGR) leads to cardiac dysfunction and adverse remodeling of the fetal heart, as well as a higher risk of postnatal cardiovascular diseases. The rat model of IUGR, via uterine artery ligation, is a popular model but its cardiac sequelae is not well investigated. Here, we performed an echocardiographic evaluation of its cardiac function to determine how well it can represent the disease in humans. Methods Unilateral uterine artery ligation was performed at embryonic day 17 (E17) and echocardiography was performed at E19 and E20. Results Growth-restricted fetuses were significantly smaller and lighter, and had an higher placenta-to-fetus weight ratio. Growth-restricted fetal hearts had reduced wall thickness-to-diameter ratio, indicating left ventricular (LV) dilatation, and they had elevated trans-mitral and trans-tricuspid E/A ratios and reduced left and right ventricular fractional shortening (FS), suggesting systolic and diastolic dysfunction. These were similar to human IUGR fetuses. However, growth-restricted rat fetuses did not demonstrate head-sparing effect, displayed a lower LV myocardial performance index, and ventricular outflow velocities were not significantly reduced, which were dissimilar to human IUGR fetuses. Conclusions Despite the differences, our results suggest that this IUGR model has significant cardiac dysfunction, and could be a suitable model for studying IUGR cardiovascular physiology. Impact Animal models of IUGR are useful, but their fetal cardiac function is not well studied, and it is unclear if they can represent human IUGR fetuses. We performed an echocardiographic assessment of the heart function of a fetal rat model of IUGR, created via maternal uterine artery ligation. Similar to humans, the model displayed LV dilatation, elevated E/A ratios, and reduced FS. Different from humans, the model displayed reduced MPI, and no significant outflow velocity reduction. Despite differences with humans, this rat model still displayed cardiac dysfunction and is suitable for studying IUGR cardiovascular physiology.

P15.12: Association of first trimester uterine artery Doppler indices with maternal diastolic cardiac function

2005 ◽  
Vol 26 (4) ◽  
pp. 464-465
Author(s):  
F. Prefumo ◽  
A. T. Papageorghiou ◽  
R. Sharma ◽  
D. Gaze ◽  
B. Thilaganathan
Keyword(s):  
Cardiac Function ◽  
Uterine Artery ◽  
First Trimester ◽  
Uterine Artery Doppler ◽  
Doppler Indices ◽  
Diastolic Cardiac Function
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