Neurodevelopmental outcome in isolated mild fetal ventriculomegaly: systematic review and meta-analysis

2014 ◽  
Vol 44 (3) ◽  
pp. 254-260 ◽  
Author(s):  
G. Pagani ◽  
B. Thilaganathan ◽  
F. Prefumo
2019 ◽  
Vol 53 (3) ◽  
pp. 293-301 ◽  
Author(s):  
A. Inversetti ◽  
L. Van der Veeken ◽  
D. Thompson ◽  
K. Jansen ◽  
F. Van Calenbergh ◽  
...  

2015 ◽  
Vol 109 ◽  
pp. 155-162 ◽  
Author(s):  
Elysa Widjaja ◽  
Cristina Go ◽  
Blathnaid McCoy ◽  
O. Carter Snead

Neonatology ◽  
2012 ◽  
Vol 102 (2) ◽  
pp. 98-103 ◽  
Author(s):  
Ola Didrik Saugstad ◽  
Maximo Vento ◽  
Siddarth Ramji ◽  
Diantha Howard ◽  
Roger F. Soll

Author(s):  
Roos Vliegenthart ◽  
Martijn Miedema ◽  
Gerard J Hutten ◽  
Anton H van Kaam ◽  
Wes Onland

BackgroundPlacebo-controlled trials have shown that caffeine is highly effective in treating apnoea of prematurity and reduces the risk of bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI).ObjectiveTo identify, appraise and summarise studies investigating the modulating effect of different caffeine dosages.MethodsA systematic review identified all randomised controlled trials (RCTs) comparing a high versus a standard caffeine treatment regimen in infants with a gestational age <32 weeks, by searching the main electronic databases and abstracts of the Pediatric Academic Societies. Studies comparing caffeine to placebo or theophylline only were excluded. Primary outcomes were BPD and mortality at 36 weeks postmenstrual age. Secondary key-outcome was neurodevelopmental outcome at 12 and 24 months corrected age. Meta-analysis was performed using RevMan 5.3.ResultsSix RCTs including 620 infants were identified. Meta-analysis showed a significant decrease in BPD, the combined outcome BPD or mortality, and failure to extubate in infants allocated to a higher caffeine dose. No differences were found in mortality alone and NDI. The quality of the outcome measures were deemed low to very low according to the Grading of Recommendations Assessment, Development and Evaluation guidelines.ConclusionsAlthough this review suggests that administering a higher dose of caffeine might enhance its beneficial effect on death or BPD, firm recommendations on the optimal caffeine dose cannot be given due to the low level of evidence. A large RCT is urgently needed to confirm or refute these findings and determine the optimal dose of caffeine.


2004 ◽  
Vol 191 (6) ◽  
pp. S145
Author(s):  
Matthew Laskin ◽  
John C.P. Kingdom ◽  
Ants Toi ◽  
David Chitayat ◽  
Arne Ohlsson

2005 ◽  
Vol 18 (5) ◽  
pp. 289-298 ◽  
Author(s):  
Matthew D. Laskin ◽  
John Kingdom ◽  
Ants Toi ◽  
David Chitayat ◽  
Arne Ohlsson

Author(s):  
Raffaele Falsaperla ◽  
Sarah Sciuto ◽  
Daniela Gioè ◽  
Laura Sciuto ◽  
Francesco Pisani ◽  
...  

Objective Hypoxic–ischemic encephalopathy (HIE) is the second cause of neonatal deaths and one of the main conditions responsible for long-term neurological disability. Contrary to past belief, children with mild HIE can also experience long-term neurological sequelae. The aim of this systematic review is to determine the predictive value of long-term neurological outcome of (electroencephalogram) EEG/amplitude-integrated electroencephalogram (aEEG) in children who complained mild HIE. Study Design From a first search on PubMed, Google Scholar, and clinicalTrials.gov databases, only five articles were considered suitable for this study review. A statistical meta-analysis with the evaluation of odds ratio was performed on three of these studies. Results No correlation was found between the characteristics of the electrical activity of the brain obtained through EEG/aEEG in infants with mild HIE and subsequent neurological involvement. Conclusion EEG/aEEG monitoring in infants with mild HIE cannot be considered a useful tool in predicting their neurodevelopmental outcome, and its use for this purpose is reported as barely reliable. Key Points


2014 ◽  
Vol 44 (S1) ◽  
pp. 109-110
Author(s):  
F. D'Antonio ◽  
A. Youssef ◽  
A. Khalil ◽  
A.T. Papageorghiou ◽  
G. Pilu

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