scholarly journals Re: Maternal age and adverse pregnancy outcome: a cohort study. A. Khalil, A. Syngelaki, N. Maiz, Y. Zinevich and K. H. Nicolaides. Ultrasound Obstet Gynecol 2013; 42: 634-643

2013 ◽  
Vol 42 (6) ◽  
pp. 613-614
Author(s):  
F. Audibert
Keyword(s):  
Cohort Study ◽  
Pregnancy Outcome ◽  
Maternal Age ◽  
Obstet Gynecol ◽  
Adverse Pregnancy Outcome ◽  
Adverse Pregnancy

Maternal age and adverse pregnancy outcome: a cohort study

2013 ◽  
Vol 42 (6) ◽  
pp. 634-643 ◽  
Author(s):  
A. Khalil ◽  
A. Syngelaki ◽  
N. Maiz ◽  
Y. Zinevich ◽  
K. H. Nicolaides
Keyword(s):  
Cohort Study ◽  
Pregnancy Outcome ◽  
Maternal Age ◽  
Adverse Pregnancy Outcome ◽  
Adverse Pregnancy

scholarly journals Advanced Maternal Age and Adverse Pregnancy Outcome: Evidence from a Large Contemporary Cohort

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56583 ◽  
Author(s):  
Louise C. Kenny ◽  
Tina Lavender ◽  
Roseanne McNamee ◽  
Sinéad M. O’Neill ◽  
Tracey Mills ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Maternal Age ◽  
Adverse Pregnancy Outcome ◽  
Advanced Maternal Age ◽  
Adverse Pregnancy

scholarly journals A Prospective Cohort Study providing Insights for Markers of Adverse Pregnancy Outcome in Women of Advanced Maternal Age

2020 ◽  
Author(s):  
Samantha Lean ◽  
Rebecca Jones ◽  
Stephen Roberts ◽  
Alexander Heazell
Keyword(s):  
Oxidative Stress ◽  
Pregnancy Outcome ◽  
Maternal Age ◽  
Adverse Outcome ◽  
Adverse Pregnancy Outcome ◽  
Advanced Maternal Age ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Adverse Pregnancy ◽  
And Oxidative Stress

Abstract Background Advanced maternal age (AMA; ≥35 years) is associated with increased rates of adverse pregnancy outcome. Better understanding of underlying pathophysiological processes may improve identification of AMA mothers who are at greatest risk of adverse outcome. This study aimed to investigate changes in oxidative stress and inflammation in AMA women and identify clinical and biochemical predictors of adverse pregnancy outcome in women of AMA.Methods The Manchester Advanced Maternal Age Study (MAMAS) was a multicentre, observational, prospective cohort study of 527 mothers. Participants were divided into three age groups for comparison 20-30 years (n=158), 35-39 years (n=212) and ≥40 years (n=157). Demographic and medical data were collected along with maternal blood samples at 28 and 36 weeks’ gestation. Multivariable analysis was conducted to identify variables associated with adverse outcome, defined as one or more of: small for gestational age (<10th centile), FGR (<5th centile), stillbirth, NICU admission, preterm birth <37 weeks gestation or Apgar score <7 at 5 minutes. Biomarkers of inflammation, oxidative stress and placental dysfunction were quantified in maternal serum. Univariate and multivariable statistical analyses were used to identify associations with composite adverse fetal outcome.Results: Maternal smoking was associated with adverse outcome in older mothers (Adjusted Odds Ratio (AOR) 4.34, 95% Confidence Interval (95%CI) 1.88, 9.99), whereas multiparity reduced the odds (AOR 0.56, 95% CI 0.34, 0.99). In uncomplicated AMA pregnancies, lower circulating anti-inflammatory IL-10, IL-RA and increased antioxidant capacity (TAC) were seen. In AMA with adverse outcome, TAC and oxidative stress markers were increased and levels of maternal circulating placental hormones (hPL, PlGF and sFlt-1) were reduced (p<0.05). Of these, placental growth factor had the strongest predictive accuracy (Area Under the Receiver Operator Characteristic (AUROC) = 0.74) followed by TAC (AUROC=0.69).Conclusions: This study identified alterations in circulating inflammatory and oxidative stress markers in AMA women and in AMA women with adverse pregnancy outcome providing preliminary evidence of mechanistic links. Further, larger studies are required to determine if these markers can be developed into a predictive model of an individual AMA woman’s risk of APO, enabling a reduction in stillbirth rates whilst minimising unnecessary intervention.

scholarly journals Adverse Pregnancy Outcome among Different Maternal Age group - A Comparative Study

2020 ◽  
Vol 3 (7) ◽  
pp. 163-169
Author(s):  
Dr. Serajoom Munira ◽  
Professor Roksana Ivy ◽  
Professor Fatema Ashraf ◽  
Dr. Mohammad Ibrahim Khalil
Keyword(s):  
Comparative Study ◽  
Pregnancy Outcome ◽  
Maternal Age ◽  
Adverse Pregnancy Outcome ◽  
Age Group ◽  
Group A ◽  
Adverse Pregnancy

scholarly journals Birth Weight Ratio as an Alternative to Birth Weight Percentile to Express Infant Weight in Research and Clinical Practice: A Nationwide Cohort Study

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Bart Jan Voskamp ◽  
Brenda M. Kazemier ◽  
Ewoud Schuit ◽  
Ben Willem J. Mol ◽  
Maarten Buimer ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Pregnancy Outcome ◽  
Perinatal Death ◽  
Adverse Pregnancy Outcome ◽  
Weight Ratio ◽  
Discriminative Ability ◽  
Birth Weight Percentile ◽  
Adverse Pregnancy ◽  
Weight Percentile

Objective. To compare birth weight ratio and birth weight percentile to express infant weight when assessing pregnancy outcome.Study Design. We performed a national cohort study. Birth weight ratio was calculated as the observed birth weight divided by the median birth weight for gestational age. The discriminative ability of birth weight ratio and birth weight percentile to identify infants at risk of perinatal death (fetal death and neonatal death) or adverse pregnancy outcome (perinatal death + severe neonatal morbidity) was compared using the area under the curve. Outcomes were expressed stratified by gestational age at delivery separate for birth weight ratio and birth weight percentile.Results. We studied 1,299,244 pregnant women, with an overall perinatal death rate of 0.62%. Birth weight ratio and birth weight percentile have equivalent overall discriminative performance for perinatal death and adverse perinatal outcome. In late preterm infants (33+0–36+6weeks), birth weight ratio has better discriminative ability than birth weight percentile for perinatal death (0.68 versus 0.63,P  0.01) or adverse pregnancy outcome (0.67 versus 0.60,P<0.001).Conclusion. Birth weight ratio is a potentially valuable instrument to identify infants at risk of perinatal death and adverse pregnancy outcome and provides several advantages for use in research and clinical practice. Moreover, it allows comparison of groups with different average birth weights.

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