Assessment of fetal cardiomyopathy in early-stage twin-twin transfusion syndrome: comparison between commonly reported cardiovascular assessment scores

2014 ◽  
Vol 43 (6) ◽  
pp. 646-651 ◽  
Author(s):  
C. R. Villa ◽  
M. Habli ◽  
J. K. Votava-Smith ◽  
J. F. Cnota ◽  
F.-Y. Lim ◽  
...  
Keyword(s):  
Early Stage ◽  
Assessment Scores ◽  
Cardiovascular Assessment ◽  
Fetal Cardiomyopathy

scholarly journals Assessing the Mobility of Elderly People in Domestic Smart Home Environments

2020 ◽  
Author(s):  
Björn Friedrich ◽  
Enno-Edzard Steen ◽  
Sebastian Fudickar ◽  
Andreas Hein
Keyword(s):  
Elderly People ◽  
Smart Home ◽  
Continuous Monitoring ◽  
Early Stage ◽  
Motion Sensor ◽  
Motion Sensors ◽  
Physical Strength ◽  
Assessment Scores ◽  
Mobility Assessment ◽  
Smart Home Environments

A continuous monitoring of the physical strength and mobility of elderly people is important for maintaining their health and treating diseases at an early stage. However, frequent screenings by physicians are exceeding the logistic capacities. An alternate approach is the automatic and unobtrusive collection of functional measures by ambient sensors. In the current publication, we show the correlation among data of ambient motion sensors and the wellestablished mobility assessment Short-Physical-Performance-Battery and Tinetti. We use the average number of motion sensor events for correlation with the assessment scores. The evaluation on a real-world dataset shows a moderate to strong correlation with the scores of standardised geriatrics physical assessments.

scholarly journals ROLE OF FLIPPED CLASSROOM METHOD IN SHORT AND LONG TERM RETENTION IN ANATOMY

2020 ◽  
Author(s):  
Payal Kasat ◽  
Vishwajit Deshmukh ◽  
Gayatri Muthiyan ◽  
Gugapriya T.S. ◽  
Aaditya Tarnekar ◽  
...  
Keyword(s):  
Medical Education ◽  
Flipped Classroom ◽  
Early Stage ◽  
Student Centered ◽  
Assessment Scores ◽  
Term Retention ◽  
Short And Long Term ◽  
Long Term Retention ◽  
Teaching Learning

Introduction: Medical education is changing towards more flexible, effective, active and student-centered teaching strategies that reduces the limitations of traditional methods of education. Recently, the flipped classroom method has been suggested to support this transition. However, research on the use of flipped classroom method in medical education is at its early stage and little is known about its effect on students learning in relation to short and long-term retention of the topics. Aims: The present paper aims to study the comparative effect of traditional and flipped classroom method on short-term and long-term memories of first MBBS students in Anatomy with the aid of technology to promote learning. Materials and methods: 50 first year MBBS students were subjected to traditional and flipped classroom module separately. Immediate assessments were done at the completion of the module. Followed by a gap of 2 months, the students were again assessed on the content taught in the module as a part of formative assessment. The data so obtained was compared and analyzed statistically. Result: The assessment scores showed differences between the two methods of teaching in short as well as long term. The flipped classroom method was observed to have significant long-term retention which was evident by assessment scores. Conclusion: The study concludes that flipped classroom method serves as an advantageous tool and motivating factor for effective learning, understanding and retention of conceptual and factual anatomical content. Keywords: Traditional classroom, flipped classroom, teaching learning method

scholarly journals Analysing the Correlation of Geriatric Assessment Scores and Activity in Smart Homes

2021 ◽  
Vol 12 (2) ◽  
pp. 1-15
Author(s):  
Björn Friedrich ◽  
Enno-Edzard Steen ◽  
Sebastian Fudickar ◽  
Andreas Hein
Keyword(s):  
Elderly People ◽  
Real World ◽  
Strong Correlation ◽  
Continuous Monitoring ◽  
Early Stage ◽  
Motion Sensor ◽  
Motion Sensors ◽  
Physical Strength ◽  
Assessment Scores ◽  
Activity Measure

A continuous monitoring of the physical strength and mobility of elderly people is important for maintaining their health and treating diseases at an early stage. However, frequent screenings by physicians are exceeding the logistic capacities. An alternate approach is the automatic and unobtrusive collection of functional measures by ambient sensors. In the current publication, we show the correlation among data of ambient motion sensors and the well-established mobility assessments Short-PhysicalPerformance-Battery, Tinetti and Timed Up & Go. We use the average number of motion sensor events as activity measure for correlation with the assessment scores. The evaluation on a real-world dataset shows a moderate to strong correlation with the scores of standardised geriatrics physical assessments.

scholarly journals Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson’s disease enrolled in PPMI

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Young Eun Huh ◽  
Hyejung Park ◽  
Ming Sum Ruby Chiang ◽  
Idil Tuncali ◽  
Ganqiang Liu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
De Novo ◽  
Early Stage ◽  
Rapid Decline ◽  
Healthy Controls ◽  
Protein Coding ◽  
Assessment Scores ◽  
Liquid Chromatography Tandem Mass

AbstractProtein-coding variants in the GBA gene modulate susceptibility and progression in ~10% of patients with Parkinson’s disease (PD). GBA encodes the β-glucocerebrosidase enzyme that hydrolyzes glucosylceramide. We hypothesized that GBA mutations will lead to glucosylceramide accumulation in cerebrospinal fluid (CSF). Glucosylceramide, ceramide, sphingomyelin, and lactosylceramide levels were measured by liquid chromatography-tandem mass spectrometry in CSF of 411 participants from the Parkinson’s Progression Markers Initiative (PPMI) cohort, including early stage, de novo PD patients with abnormal dopamine transporter neuroimaging and healthy controls. Forty-four PD patients carried protein-coding GBA variants (GBA-PD) and 227 carried wild-type alleles (idiopathic PD). The glucosylceramide fraction was increased (P = 0.0001), and the sphingomyelin fraction (a downstream metabolite) was reduced (P = 0.0001) in CSF of GBA-PD patients compared to healthy controls. The ceramide fraction was unchanged, and lactosylceramide was below detection limits. We then used the ratio of glucosylceramide to sphingomyelin (the GlcCer/SM ratio) to explore whether these two sphingolipid fractions altered in GBA-PD were useful for stratifying idiopathic PD patients. Idiopathic PD patients in the top quartile of GlcCer/SM ratios at baseline showed a more rapid decline in Montreal Cognitive Assessment scores during longitudinal follow-up compared to those in the lowest quartile with a P-value of 0.036. The GlcCer/SM ratio was negatively associated with α-synuclein levels in CSF of PD patients. This study highlights glucosylceramide as a pathway biomarker for GBA-PD patients and the GlcCer/SM ratio as a potential stratification tool for clinical trials of idiopathic PD patients. Our sphingolipids data together with the clinical, imaging, omics, and genetic characterization of PPMI will contribute a useful resource for multi-modal biomarkers development.

Alterations in the number of motoneurons containing immunoreactive calcitonin gene-related peptide(CGRP)& choline acetyltransferase(ChAT) in the cervical spinal cord of the wobbler mouse during the development of the motoneuron disease

1995 ◽  
Vol 53 ◽  
pp. 970-971
Author(s):  
L. Vacca-Galloway ◽  
Y.Q. Zhang ◽  
P. Bose ◽  
S.H. Zhang
Keyword(s):  
Spinal Cord ◽  
Early Stage ◽  
Cervical Spinal Cord ◽  
Wild Type Mouse ◽  
Reflex Response ◽  
Mouse Strains ◽  
Behavioral Tests ◽  
Wobbler Mouse ◽  
Stage 4 ◽  
Stage 1

The Wobbler mouse (wr) has been studied as a model for inherited human motoneuron diseases (MNDs). Using behavioral tests for forelimb power, walking, climbing, and the “clasp-like reflex” response, the progress of the MND can be categorized into early (Stage 1, age 21 days) and late (Stage 4, age 3 months) stages. Age-and sex-matched normal phenotype littermates (NFR/wr) were used as controls (Stage 0), as well as mice from two related wild-type mouse strains: NFR/N and a C57BI/6N. Using behavioral tests, we also detected pre-symptomatic Wobblers at postnatal ages 7 and 14 days. The mice were anesthetized and perfusion-fixed for immunocytochemical (ICC) of CGRP and ChAT in the spinal cord (C3 to C5).Using computerized morphomety (Vidas, Zeiss), the numbers of IR-CGRP labelled motoneurons were significantly lower in 14 day old Wobbler specimens compared with the controls (Fig. 1). The same trend was observed at 21 days (Stage 1) and 3 months (Stage 4). The IR-CGRP-containing motoneurons in the Wobbler specimens declined progressively with age.

Automated high-resolution microscopy: the approaches so far

1987 ◽  
Vol 45 ◽  
pp. 58-61
Author(s):  
W. O. Saxton
Keyword(s):  
High Resolution ◽  
Early Stage ◽  
Automatic Recording ◽  
Microprocessor Control ◽  
Alternative Systems ◽  
Electron Image ◽  
Complete Automation ◽  
Analysis System ◽  
High Resolution Microscopy

Recent commercial microscopes with internal microprocessor control of all major functions have already demonstrated some of the benefits anticipated from such systems, such as continuous magnification, rotation-free diffraction and magnification, automatic recording of mutually registered focal series, and fewer control knobs. Complete automation of the focusing, stigmating and alignment of a high resolution microscope, allowing focal series to be recorded at preselected focus values as well, is still imminent rather than accomplished, however; some kind of image pick-up and analysis system, fed with the electron image via a TV camera, is clearly essential for this, but several alternative systems and algorithms are still being explored. This paper reviews the options critically in turn, and stresses the need to consider alignment and focusing at an early stage, and not merely as an optional extension to a basic proposal.

Direct observation of Fe-Al-Zn ternary intermetallic compound and its transformation during the early stage of hot-dip galvanizing

1993 ◽  
Vol 51 ◽  
pp. 1116-1117
Author(s):  
C. S. Lin ◽  
W. A. Chiou ◽  
M. Meshii
Keyword(s):  
Intermetallic Compound ◽  
Reaction Rate ◽  
Diffusion Rate ◽  
Early Stage ◽  
Zinc Bath ◽  
Steel Sheets ◽  
Direct Observations ◽  
Solid Iron ◽  
Iron And Zinc ◽  
Ternary Intermetallic Compound

The galvannealed steel sheets have received ever increased attention because of their excellent post-painting corrosion resistance and good weldability. However, its powdering and flaking tendency during press forming processes strongly impairs its performance. In order to optimize the properties of galvanneal coatings, it is critical to control the reaction rate between solid iron and molten zinc.In commercial galvannealing line, aluminum is added to zinc bath to retard the diffusion rate between iron and zinc by the formation of a thin layer of Al intermetallic compound on the surface of steel at initial hot-dip galvanizing. However, the form of this compound and its transformation are still speculated. In this paper, we report the direct observations of this compound and its transformation.The specimens were prepared in a hot-dip simulator in which the steel was galvanized in the zinc bath containing 0.14 wt% of Al at a temperature of 480 °C for 5 seconds and was quenched by liquid nitrogen.

Anisotropy of interfacial defects in the initial stage of MOVPE GaAs growth On Si

1990 ◽  
Vol 48 (4) ◽  
pp. 592-593
Author(s):  
C. Vannuffel ◽  
C. Schiller ◽  
J. P. Chevalier
Keyword(s):  
Early Stage ◽  
Threading Dislocations ◽  
Mbe Growth ◽  
Detailed Mechanism ◽  
Si Substrates ◽  
Initial Stage ◽  
Interfacial Defects ◽  
Interfacial Dislocations ◽  
Step Growth ◽  
Essential Problem

Recently, interest has focused on the epitaxy of GaAs on Si as a promising material for electronic applications, potentially for integration of optoelectronic devices on silicon wafers. The essential problem concerns the 4% misfit between the two materials, and this must be accommodated by a network of interfacial dislocations with the lowest number of threading dislocations. It is thus important to understand the detailed mechanism of the formation of this network, in order to eventually reduce the dislocation density at the top of the layers.MOVPE growth is carried out on slightly misoriented, (3.5°) from (001) towards , Si substrates. Here we report on the effect of this misorientation on the interfacial defects, at a very early stage of growth. Only the first stage, of the well-known two step growth process, is thus considered. Previously, we showed that full substrate coverage occured for GaAs thicknesses of 5 nm in contrast to MBE growth, where substantially greater thicknesses are required.

1596: Choices for Definitive Treatment of Early-Stage Prostate Cancer: Results from the Compare Registry

2006 ◽  
Vol 175 (4S) ◽  
pp. 514-514
Author(s):  
David G. McLeod ◽  
Oliver Sartor ◽  
Paul F. Schellhammer ◽  
Anthony V. D'Amico ◽  
Susan Halabi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Early Stage ◽  
Definitive Treatment

644: Cathepsin D is a Marker for Early Stage Renal Cell Cancer and Predicts the Presence of Distant Metastases

2005 ◽  
Vol 173 (4S) ◽  
pp. 175-175
Author(s):  
Axel S. Merseburger ◽  
Joerg Hennenlotter ◽  
Perikles Simon ◽  
Marcus Horstmann ◽  
Arnulf Stenzl ◽  
...  
Keyword(s):  
Renal Cell Cancer ◽  
Renal Cell ◽  
Cathepsin D ◽  
Early Stage ◽  
Cell Cancer ◽  
Distant Metastases
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