scholarly journals OP19.02: Influence of maternal age on first trimester crown-rump length and birth outcomes: a population-based study

2013 ◽  
Vol 42 (s1) ◽  
pp. 101-101
Author(s):  
A. Metcalfe ◽  
S. Tough ◽  
J. Johnson
Keyword(s):  
Birth Outcomes ◽  
Maternal Age ◽  
First Trimester ◽  
Population Based ◽  
Population Based Study ◽  
Crown Rump Length

scholarly journals Effect of older maternal age on birth outcomes in twin pregnancies: a population-based study

2010 ◽  
Vol 31 (2) ◽  
pp. 85-91 ◽  
Author(s):  
S Lisonkova ◽  
S B Sheps ◽  
P A Janssen ◽  
S K Lee ◽  
L Dahlgren
Keyword(s):  
Birth Outcomes ◽  
Maternal Age ◽  
Population Based ◽  
Population Based Study ◽  
Twin Pregnancies

scholarly journals Perinatal use and discontinuation of disease-modifying anti-rheumatic drugs and biologics in women with rheumatoid arthritis: a cohort study

Rheumatology ◽  
2019 ◽  
Vol 59 (7) ◽  
pp. 1514-1521
Author(s):  
Nevena Rebić ◽  
Eric C Sayre ◽  
Enav Z Zusman ◽  
Neda Amiri ◽  
Corisande Baldwin ◽  
...  
Keyword(s):  
Maternal Age ◽  
Regression Models ◽  
Birth Outcome ◽  
First Trimester ◽  
Population Based ◽  
Singleton Pregnancy ◽  
Population Based Study ◽  
Logistic Regression Models ◽  
Medication Discontinuation ◽  
Synthetic Dmards

Abstract Objectives To characterize the utilization and discontinuation of medications before, during and after pregnancy among women with RA. Methods We used population-based administrative data to identify women with RA who had a singleton pregnancy ending in delivery between 1 January 2002 and 31 December 2012. We assessed the utilization of RA medications, namely, conventional synthetic DMARDs, biologics, glucocorticosteroids and NSAIDs, across six windows spanning 24 and 12 months before the start of pregnancy, each trimester of pregnancy and 12 months post-pregnancy. We defined medication discontinuation as no prescription in a given window following a prescription in the preceding window and evaluated predictors using logistic regression models, calculating adjusted odds ratios (ORs) and 95% CIs. Results We studied 1730 pregnancies in 1301 women with RA (mean age at delivery 31.4 ± 5.4 years). We observed substantial medication discontinuation, particularly in the first trimester, with discontinuation of antimalarials in 57.3% of patients, azathioprine 59.1%, sulfasalazine 69.5% and biologics 50.8%. Factors inversely associated with discontinuation of antimalarials in the first trimester were maternal age [OR 0.90 (95% CI 0.86, 0.95)] and number of rheumatology visits [OR 0.86 (95% CI 0.75, 0.97)] and for biologics, prior adverse birth outcome [OR 0.22 (95% CI 0.05, 0.95)]. Conclusion Our population-based study shows frequent discontinuation of medications for RA, particularly in the first trimester. Findings indicate a need to educate women with RA who are planning pregnancy on the benefits and risks of medications during pregnancy.

scholarly journals Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Chalana M. Sol ◽  
Charissa van Zwol - Janssens ◽  
Elise M. Philips ◽  
Alexandros G. Asimakopoulos ◽  
Maria-Pilar Martinez-Moral ◽  
...  
Keyword(s):  
Birth Outcomes ◽  
Fetal Growth ◽  
Head Circumference ◽  
Lower Risk ◽  
First Trimester ◽  
Population Based ◽  
Third Trimester ◽  
Bisphenol S ◽  
Fetal Head ◽  
Urine Concentrations

Abstract Background Exposure to bisphenols may affect fetal growth and development. The trimester-specific effects of bisphenols on repeated measures of fetal growth remain unknown. Our objective was to assess the associations of maternal bisphenol urine concentrations with fetal growth measures and birth outcomes and identify potential critical exposure periods. Methods In a population-based prospective cohort study among 1379 pregnant women, we measured maternal bisphenol A, S and F urine concentrations in the first, second and third trimester. Fetal head circumference, length and weight were measured in the second and third trimester by ultrasound and at birth. Results An interquartile range increase in maternal pregnancy-averaged bisphenol S concentrations was associated with larger fetal head circumference (difference 0.18 (95% confidence interval (CI) 0.01 to 0.34) standard deviation scores (SDS), p-value< 0.05) across pregnancy. When focusing on specific critical exposure periods, any detection of first trimester bisphenol S was associated with larger second and third trimester fetal head circumference (difference 0.15 (95% CI 0.05 to 0.26) and 0.12 (95% CI 0.02 to 0.23) SDS, respectively) and fetal weight (difference 0.12 (95% CI 0.02 to 0.22) and 0.16 (95% CI 0.06 to 0.26) SDS, respectively). The other bisphenols were not consistently associated with fetal growth outcomes. Any detection of bisphenol S and bisphenol F in first trimester was also associated with a lower risk of being born small size for gestational age (Odds Ratio 0.56 (95% CI 0.38 to 0.74) and 0.55 (95% CI 0.36 to 0.85), respectively). Bisphenols were not associated with risk of preterm birth. Conclusions Higher maternal bisphenol S urine concentrations, especially in the first trimester, seem to be related with larger fetal head circumference, higher weight and a lower risk of being small size for gestational age at birth.

scholarly journals Association between maternal age at delivery and allergic rhinitis in schoolchildren: A population-based study

2020 ◽  
Vol 13 (6) ◽  
pp. 100127
Author(s):  
Hung-Yi Lu ◽  
Chi-Wei Chiu ◽  
Po-Hsiang Kao ◽  
Zhao-Ting Tsai ◽  
Chun-Chun Gau ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Maternal Age ◽  
Population Based ◽  
Population Based Study

scholarly journals Maternal occupational exposure to solvents and gastroschisis in offspring - National Birth Defects Prevention Study 1997–2011

2020 ◽  
Vol 77 (3) ◽  
pp. 172-178 ◽  
Author(s):  
Nynke Spinder ◽  
Lynn M Almli ◽  
Tania A Desrosiers ◽  
Kathryn E Arnold ◽  
Jorieke E H Bergman ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Birth Defects ◽  
Maternal Age ◽  
Large Population ◽  
First Trimester ◽  
Population Based ◽  
Cumulative Exposure ◽  
Surveillance Systems ◽  
Prevention Study ◽  
Solvent Exposure

ObjectivesThe aim of this study was to assess the association between maternal occupational exposure to solvents and gastroschisis in offspring.MethodsWe used data from the National Birth Defects Prevention Study, a large population-based case-control study of major birth defects conducted in 10 US states from 1997 to 2011. Infants with gastroschisis were ascertained by active birth defects surveillance systems. Control infants without major birth defects were selected from vital records or birth hospital records. Self-reported maternal occupational histories were collected by telephone interview. Industrial hygienists reviewed this information to estimate exposure to aromatic, chlorinated and petroleum-based solvents from 1 month before conception through the first trimester of pregnancy. Cumulative exposure to solvents was estimated for the same period accounting for estimated exposure intensity and frequency, job duration and hours worked per week. ORs and 95% CIs were estimated to assess the association between exposure to any solvents or solvent classes, and gastroschisis risk.ResultsAmong 879 cases and 7817 controls, the overall prevalence of periconceptional solvent exposure was 7.3% and 7.4%, respectively. Exposure to any solvent versus no exposure to solvents was not associated with gastroschisis after adjusting for maternal age (OR 1.00, 95% CI 0.75 to 1.32), nor was an association noted for solvent classes. There was no exposure-response relationship between estimated cumulative solvent exposure and gastroschisis after adjusting for maternal age.ConclusionOur study found no association between maternal occupational solvent exposure and gastroschisis in offspring. Further research is needed to understand risk factors for gastroschisis.

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