scholarly journals P09.06: Validation of post-mortem magnetic resonance imaging (MRI) in the evaluation of cerebellar herniation in the fetal sheep model for spina bifida

2012 ◽  
Vol 40 (S1) ◽  
pp. 205-205
Author(s):  
G. B. Santos ◽  
N. S. Bevilacqua ◽  
F. S. Abreu ◽  
S. R. Herrera ◽  
P. H. Saldiva ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Spina Bifida ◽  
Post Mortem ◽  
Resonance Imaging ◽  
Sheep Model ◽  
Fetal Sheep ◽  
Magnetic Resonance Imaging Mri

scholarly journals Post-Mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Progressive Supranuclear Palsy with and without Cerebral Amyloid Angiopathy

NeuroSci ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 115-120
Author(s):  
Jacques De Reuck ◽  
Florent Auger ◽  
Nicolas Durieux ◽  
Claude-Alain Maurage ◽  
Vincent Deramecourt ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Progressive Supranuclear Palsy ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Angiopathy ◽  
Post Mortem ◽  
Resonance Imaging ◽  
Cerebral Amyloid ◽  
Magnetic Resonance Imaging Mri ◽  
Neuropathological Examination

Introduction and Purpose: Cerebral amyloid angiopathy (CAA) can be observed in patients with progressive supranuclear palsy (PSP), though to a lesser degree than in Alzheimer’s disease. The present post-mortem 7.0-tesla magnetic resonance imaging (MRI) evaluates whether CAA has an influence on the degree of hippocampal atrophy (HA) and on the incidence of associated micro-infarcts (HMIs) and cortical micro-bleeds (HMBs). Material and Methods: Eight brains with PSP-CAA were compared to 20 PSP brains without CAA. In addition to the neuropathological examination, the hippocampus was evaluated on the most representative coronal section with T2 and T2*-weighted MRI sequences. The average degree of HA was determined in both groups. The incidence of HMIs and HMBs was also compared as well as the frequency of cortical micro-infarcts (CoMIs) and cortical micro-bleeds (CoMBs) in the hemispheric neocortex. Results: The neuropathological examination showed a higher incidence of lacunar infarcts in the PSP-CAA brains compared to the PSP ones. With magnetic resonance imaging (MRI), the severity of HA and the incidence of HMIs and HMBs was similar between both groups. Additionally, the frequency of CoMIs and CoMBs in the neocortex was comparable. Conclusions: The association of CAA in PSP brains has no influence on the degree of HA and on the incidence of the small cerebrovascular lesions in the hippocampus as well as in the neocortex.

Assessment of optic nerve development using post-mortem Magnetic Resonance Imaging (MRI) in fetuses and newborns

2015 ◽  
Vol 35 (12) ◽  
pp. 1262-1264 ◽  
Author(s):  
Audrey Soo ◽  
Syed Taha ◽  
Peter Lally ◽  
Olga Kirmi ◽  
Brynmor Jones ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Post Mortem ◽  
Resonance Imaging ◽  
Nerve Development ◽  
Magnetic Resonance Imaging Mri

scholarly journals Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging

2021 ◽  
Author(s):  
Max Scheffler ◽  
Rares Salomir ◽  
Enrique Maturana ◽  
Marie-Louise Montandon ◽  
Enikö V. Kövari ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
Magnetic Resonance ◽  
High Field ◽  
Correlation Study ◽  
Post Mortem ◽  
Resonance Imaging ◽  
Ultra High Field ◽  
Magnetic Resonance Imaging Mri ◽  
Double Blinded

AbstractCortical microinfarcts (CMI) are increasingly recognized in the neurological community as a biomarker related to cognitive impairment and dementia. If their radiological depiction has been largely described in experimental settings using ultra-high-field magnetic resonance imaging (MRI), less is known about their visibility on routinely used 3-T MRI. In this radiologic-pathologic correlation study, using 3-T post-mortem MRI, we searched for hippocampal CMI, in a double-blinded fashion, and found that only 4/36, or 11%, were clearly demonstrated on both radiological and histopathological exams.

scholarly journals Perinatal post-mortem magnetic resonance imaging (MRI) of the central nervous system (CNS): a pictorial review

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Carlos Pérez-Serrano ◽  
Álvaro Bartolomé ◽  
Núria Bargalló ◽  
Carmen Sebastià ◽  
Alfons Nadal ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Post Mortem ◽  
Resonance Imaging ◽  
Pictorial Review ◽  
The Central Nervous System ◽  
Magnetic Resonance Imaging Mri ◽  
Histopathological Results

AbstractCentral nervous system (CNS) abnormalities cause approximately 32–37.7% of terminations of pregnancy (TOP). Autopsy is currently the gold standard for assessing dead foetuses and stillborn. However, it has limitations and is sometimes subject to parental rejection. Recent studies have described post-mortem foetal magnetic resonance imaging (MRI) as an alternative and even complementary to autopsy for CNS assessment. Radiologists now play a key role in the evaluation of perinatal deaths. Assessment of foetal CNS abnormalities is difficult, and interpretation of foetal studies requires familiarisation with normal and abnormal findings in post-mortem MRI studies as well as the strengths and limitations of the imaging studies. The purpose of this pictorial review is to report our experience in the post-mortem MRI evaluation of the CNS system, including a description of the protocol used, normal CNS findings related to post-mortem status, abnormal CNS findings in our sample, and the correlation of these findings with histopathological results.

scholarly journals Comparison of Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Brains of Alzheimer Patients with and without Cerebral Amyloid Angiopathy

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Jacques De Reuck ◽  
◽  
Florent Auger ◽  
Nicolas Durieux ◽  
Claude-Alain Maurage ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Angiopathy ◽  
Post Mortem ◽  
Resonance Imaging ◽  
Cerebrovascular Lesions ◽  
Mri Sequences ◽  
Cerebral Amyloid ◽  
Magnetic Resonance Imaging Mri

Purpose: The influence of cerebral amyloid angiopathy (CAA) in Alzheimer’s disease (AD) remains unexplored. The present post-mortem study investigated possible differences in the degree of hippocampal atrophy (HA) between AD patients with and without CAA using 7.0-tesla magnetic resonance imaging (MRI). Also, the incidence of the hippocampal cortical micro-infarcts (HCoMIs) and hippocampal cortical micro-bleeds (HCoMBs) is compared to those in the neocortex. Methods: The examined post-mortem brains included 30 AD-CAA cases and 20 AD without CAA cases. The samples of the hippocampus were evaluated on the most representative coronal section with T2 and T2* MRI sequences. The average degree of HA was determined in both groups. The incidences of HCoMIs and HCoMBs, along with the frequency of CoMIs and CoMBs in the neocortex were compared in both groups: AD-with CAA and AD without CAA cases. Results: No significant differences were observed in the degree of HA and the incidence of hippocampal micro-infarcts (HMIs) and hippocampal micro-bleeds (HMBs) between the AD-CAA and the AD brains in contrast to the higher incidence of these cerebrovascular lesions in the neocortex of AD-CAA brains. The incidence of CoMIs and CoMBs in the neocortex showed similarity to that in the hippocampus of AD patients without CAA. Conclusions: CAA does not influence the degree of HA and the incidence of micro-infarcts (MIs) and micro-bleeds (MBs) in the hippocampus, in contrast to the high contribution of the latter with CAA in the neocortex. The hippocampus seems to be more spared from cerebrovascular involvement than the other parts of the brain.

scholarly journals What brain abnormalities can magnetic resonance imaging detect in foetal and early neonatal spina bifida: a systematic review

2021 ◽  
Author(s):  
Nada Mufti ◽  
Adalina Sacco ◽  
Michael Aertsen ◽  
Fred Ushakov ◽  
Sebastian Ourselin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Spina Bifida ◽  
Wide Spectrum ◽  
Meta Analysis ◽  
Preoperative Evaluation ◽  
Cortical Folding ◽  
Resonance Imaging ◽  
Brain Abnormalities ◽  
Magnetic Resonance Imaging Mri

Abstract Purpose Open spina bifida (OSB) encompasses a wide spectrum of intracranial abnormalities. With foetal surgery as a new treatment option, robust intracranial imaging is important for comprehensive preoperative evaluation and prognostication. We aimed to determine the incidence of infratentorial and supratentorial findings detected by magnetic resonance imaging (MRI) alone and MRI compared to ultrasound. Methods Two systematic reviews comparing MRI to ultrasound and MRI alone were conducted on MEDLINE, EMBASE, and Cochrane databases identifying studies of foetal OSB from 2000 to 2020. Intracranial imaging findings were analysed at ≤ 26 or > 26 weeks gestation and neonates (≤ 28 days). Data was independently extracted by two reviewers and meta-analysis was performed where possible. Results Thirty-six studies reported brain abnormalities detected by MRI alone in patients who previously had an ultrasound. Callosal dysgenesis was identified in 4/29 cases (2 foetuses ≤ 26 weeks, 1 foetus under any gestation, and 1 neonate ≤ 28 days) (15.1%, CI:5.7–34.3%). Heterotopia was identified in 7/40 foetuses ≤ 26 weeks (19.8%, CI:7.7–42.2%), 9/36 foetuses > 26 weeks (25.3%, CI:13.7–41.9%), and 64/250 neonates ≤ 28 days (26.9%, CI:15.3–42.8%). Additional abnormalities included aberrant cortical folding and other Chiari II malformation findings such as lower cervicomedullary kink level, tectal beaking, and hypoplastic tentorium. Eight studies compared MRI directly to ultrasound, but due to reporting inconsistencies, it was not possible to meta-analyse. Conclusion MRI is able to detect anomalies hitherto underestimated in foetal OSB which may be important for case selection. In view of increasing prenatal OSB surgery, further studies are required to assess developmental consequences of these findings.

scholarly journals P254: Lung development in fetal sheep observed with Magnetic Resonance Imaging (MRI) and ultrasound B-scan

2003 ◽  
Vol 22 (S1) ◽  
pp. 138-139
Author(s):  
M. Tchirikov ◽  
U. Wedeg�rtner ◽  
K. Hecher ◽  
J. Deprest ◽  
H. J. Schr�der
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Lung Development ◽  
Resonance Imaging ◽  
Fetal Sheep ◽  
Magnetic Resonance Imaging Mri

scholarly journals Amygdala volume in schizophrenia: post-mortem study and review of magnetic resonance imaging findings

2002 ◽  
Vol 180 (4) ◽  
pp. 331-338 ◽  
Author(s):  
Steven A. Chance ◽  
Margaret M. Esiri ◽  
Timothy J. Crow
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Post Mortem ◽  
Point Counting ◽  
Resonance Imaging ◽  
Mri Studies ◽  
Consistent Feature ◽  
Amygdala Volume ◽  
Magnetic Resonance Imaging Mri ◽  
Meta Analyses

BackgroundClaims that schizophrenia is a disease of the limbic system have been strengthened by meta-analyses of magnetic resonance imaging (MRI) studies finding reduced hippocampus and amygdala volumes. Some post-mortem studies do not find these abnormalities.AimsTo assess the volume of the amygdala in a series of brains post-mortem.MethodAmygdala volume was estimated using point-counting in both hemispheres of the brains of 10 male and 8 female patients with schizophrenia, and a comparison group of 9 males and 9 females.ResultsNo significant reduction of amygdala volume was found.ConclusionsSignificant volume reduction of the amygdala is not a consistent feature of schizophrenia; findings from early MRI studies using coarse delineation methods may introduce bias to subsequent meta-analyses.

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