scholarly journals OP37.05: Arterial spin labelling: a novel non invasive MRI technique to assess placental blood flow

2012 ◽  
Vol 40 (S1) ◽  
pp. 168-168
Author(s):  
B. Deloison ◽  
L. J. Salomon ◽  
G. E. Chalouhi ◽  
D. Balvay ◽  
C. Charles-Andre ◽  
...  
Keyword(s):  
Blood Flow ◽  
Arterial Spin Labelling ◽  
Non Invasive ◽  
Placental Blood ◽  
Placental Blood Flow ◽  
Spin Labelling

scholarly journals Non-invasive evaluation of placental blood flow: lessons from animal models

Reproduction ◽  
2017 ◽  
Vol 153 (3) ◽  
pp. R85-R96 ◽  
Author(s):  
E Mourier ◽  
A Tarrade ◽  
J Duan ◽  
C Richard ◽  
C Bertholdt ◽  
...  
Keyword(s):  
Blood Flow ◽  
Animal Models ◽  
Ultrasound Contrast Agents ◽  
Valuable Insight ◽  
Non Invasive ◽  
Placental Blood ◽  
2D And 3D ◽  
Reliable Methods ◽  
Placental Blood Flow ◽  
Invasive Evaluation

In human obstetrics, placental vascularisation impairment is frequent as well as linked to severe pathological events (preeclampsia and intrauterine growth restriction), and there is a need for reliable methods allowing non-invasive evaluation of placental blood flow. Uteroplacental vascularisation is complex, and animal models are essential for the technical development and safety assessment of these imaging tools for human clinical use; however, these techniques can also be applied in the veterinary context. This paper reviews how ultrasound-based imaging methods such as 2D and 3D Doppler can provide valuable insight for the exploration of placental blood flow both in humans and animals and how new approaches such as the use of ultrasound contrast agents or ultrafast Doppler may allow to discriminate between maternal (non-pulsatile) and foetal (pulsatile) blood flow in the placenta. Finally, functional magnetic resonance imaging could also be used to evaluate placental blood flow, as indicated by studies in animal models, but its safety in human pregnancy still requires to be confirmed.

scholarly journals Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging

2018 ◽  
Vol 39 (8) ◽  
pp. 1557-1569 ◽  
Author(s):  
James R Larkin ◽  
Manon A Simard ◽  
Alexandre A Khrapitchev ◽  
James A Meakin ◽  
Thomas W Okell ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Measurement ◽  
Arterial Spin Labelling ◽  
Sprague Dawley ◽  
Functional Studies ◽  
Non Invasive ◽  
Disease States ◽  
Preclinical Mri ◽  
Invasive Measurement ◽  
Spin Labelling

Cerebral blood flow is an important parameter in many diseases and functional studies that can be accurately measured in humans using arterial spin labelling (ASL) MRI. However, although rat models are frequently used for preclinical studies of both human disease and brain function, rat CBF measurements show poor consistency between studies. This lack of reproducibility is due, partly, to the smaller size and differing head geometry of rats compared to humans, as well as the differing analysis methodologies employed and higher field strengths used for preclinical MRI. To address these issues, we have implemented, optimised and validated a multiphase pseudo-continuous ASL technique, which overcomes many of the limitations of rat CBF measurement. Three rat strains (Wistar, Sprague Dawley and Berlin Druckrey IX) were used, and CBF values validated against gold-standard autoradiography measurements. Label positioning was found to be optimal at 45°, while post-label delay was optimised to 0.55 s. Whole brain CBF measures were 109 ± 22, 111 ± 18 and 100 ± 15 mL/100 g/min by multiphase pCASL, and 108 ± 12, 116 ± 14 and 122 ± 16 mL/100 g/min by autoradiography in Wistar, SD and BDIX cohorts, respectively. Tumour model analysis shows that the developed methods also apply in disease states. Thus, optimised multiphase pCASL provides robust, reproducible and non-invasive measurement of CBF in rats.

scholarly journals A fast analysis method for non-invasive imaging of blood flow in individual cerebral arteries using vessel-encoded arterial spin labelling angiography

2012 ◽  
Vol 16 (4) ◽  
pp. 831-839 ◽  
Author(s):  
Michael A. Chappell ◽  
Thomas W. Okell ◽  
Stephen J. Payne ◽  
Peter Jezzard ◽  
Mark W. Woolrich
Keyword(s):  
Blood Flow ◽  
Cerebral Arteries ◽  
Arterial Spin Labelling ◽  
Analysis Method ◽  
Fast Analysis ◽  
Non Invasive ◽  
Spin Labelling

Non-Invasive Radioisotopic Evaluation of Placental Blood Flow

1985 ◽  
Vol 19 (4) ◽  
pp. 196-206 ◽  
Author(s):  
C.L· Maini ◽  
P. Rosati ◽  
G. Galli ◽  
U. Bellati ◽  
M.G. Bonetti ◽  
...  
Keyword(s):  
Blood Flow ◽  
Non Invasive ◽  
Placental Blood ◽  
Placental Blood Flow

Effect of terbutaline sulphate on ovarian, uterine and maternal placental blood flow in the anaesthetized guinea pig

1978 ◽  
Vol 53 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Lena Mårtensson ◽  
Per-Ove B. Sjöquist ◽  
Leif Bjellin ◽  
Anthony M. Carter
Keyword(s):  
Blood Flow ◽  
Guinea Pig ◽  
Terbutaline Sulphate ◽  
Placental Blood ◽  
Placental Blood Flow

Fetal cardiac bypass alters regional blood flows, arterial blood gases, and hemodynamics in sheep

1992 ◽  
Vol 263 (3) ◽  
pp. H919-H928 ◽  
Author(s):  
S. M. Bradley ◽  
F. L. Hanley ◽  
B. W. Duncan ◽  
R. W. Jennings ◽  
J. A. Jester ◽  
...  
Keyword(s):  
Blood Flow ◽  
Blood Gases ◽  
Arterial Blood Gases ◽  
Blood Flows ◽  
Arterial Blood ◽  
Cardiac Bypass ◽  
Regional Blood Flows ◽  
Placental Blood ◽  
Fetal Organs ◽  
Placental Blood Flow

Successful fetal cardiac bypass might allow prenatal correction of some congenital heart defects. However, previous studies have shown that fetal cardiac bypass may result in impaired fetal gas exchange after bypass. To investigate the etiology of this impairment, we determined whether fetal cardiac bypass causes a redistribution of fetal regional blood flows and, if so, whether a vasodilator (sodium nitroprusside) can prevent this redistribution. We also determined the effects of fetal cardiac bypass with and without nitroprusside on fetal arterial blood gases and hemodynamics. Eighteen fetal sheep were studied in utero under general anesthesia. Seven fetuses underwent bypass without nitroprusside, six underwent bypass with nitroprusside, and five were no-bypass controls. Blood flows were determined using radionuclide-labeled microspheres. After bypass without nitroprusside, placental blood flow decreased by 25–60%, whereas cardiac output increased by 15–25%. Flow to all other fetal organs increased or remained unchanged. Decreased placental blood flow after bypass was accompanied by a fall in PO2 and a rise in PCO2. Nitroprusside improved placental blood flow, cardiac output, and arterial blood gases after bypass. Thus fetal cardiac bypass causes a redistribution of regional blood flow away from the placenta and toward the other fetal organs. Nitroprusside partially prevents this redistribution. Methods of improving placental blood flow in the postbypass period may prove critical to the success of fetal cardiac bypass.

P2-391: NON-INVASIVE IMAGING OF BRAIN CLEARANCE PATHWAYS USING MULTIPLE ECHO TIME ARTERIAL SPIN LABELLING: AN AQUAPORIN-4 STUDY

2006 ◽  
Vol 14 (7S_Part_15) ◽  
pp. P851-P852
Author(s):  
Yolanda Ohene ◽  
Ian F. Harrison ◽  
Payam Nahavandi ◽  
Ozama Ismail ◽  
Ole P. Ottersen ◽  
...  
Keyword(s):  
Arterial Spin Labelling ◽  
Aquaporin 4 ◽  
Non Invasive ◽  
Echo Time ◽  
Spin Labelling
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