scholarly journals High liver stiffness values by transient elastography related to metabolic syndrome and harmful alcohol use in a large Spanish cohort

2021 ◽  
Author(s):  
Elba Llop ◽  
Paula Iruzubieta ◽  
Christie Perelló ◽  
Carlos Fernández Carrillo ◽  
Joaquín Cabezas ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Alcohol Use ◽  
Transient Elastography ◽  
Liver Stiffness ◽  
Harmful Alcohol ◽  
Spanish Cohort ◽  
High Liver

Repeating measurements by transient elastography in non-alcoholic fatty liver disease patients with high liver stiffness

2018 ◽  
Vol 34 (1) ◽  
pp. 241-248 ◽  
Author(s):  
Jeremy Chak-Lun Chow ◽  
Grace Lai-Hung Wong ◽  
Anthony Wing-Hung Chan ◽  
Sally She-Ting Shu ◽  
Carmen Ka-Man Chan ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Transient Elastography ◽  
Liver Stiffness ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
High Liver

scholarly journals Liver Stiffness Measurement in Psoriasis: Do Metabolic or Disease Factors Play the Important Role?

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jamrus Pongpit ◽  
Saneerat Porntharukchareon ◽  
Piyaporn Kaewduang ◽  
Kwannapa Promson ◽  
Wasana Stitchantrakul ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Liver Fibrosis ◽  
Associated Factors ◽  
Transient Elastography ◽  
Liver Stiffness ◽  
Liver Stiffness Measurement ◽  
Nonalcoholic Fatty Liver ◽  
Stiffness Measurement ◽  
Significant Liver Fibrosis

Background. An increased prevalence of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) was reported in psoriasis. NAFLD can progress to nonalcoholic steatohepatitis and fibrosis. Transient elastography (TE) is a noninvasive liver fibrosis assessment. We evaluated the prevalence of significant liver fibrosis or high liver stiffness measurement (LSM) using the LSM cutoff over 7 kPa and its associated factors in psoriatic patients. Methods. Subjects underwent TE and ultrasonography. Univariate and multivariate analysis were performed for the associated factors. Results. One hundred and sixty-eight patients were recruited. Three patients were excluded due to TE failure. Mean BMI was 24.8±4.7 kg/m2. NAFLD, metabolic syndrome, and diabetes were seen in 105 (63.6%), 83 (50.3%), and 31 (18.8%) patients. The total cumulative dose of methotrexate over 1.5 g was seen in 39 (23.6%) patients. Mean LSM was 5.3±2.9 kPa. High LSM was found in 18 (11.0%) patients. Waist circumference (OR: 1.24; 95% CI: 1.11–1.38; P=0.0002), diabetes (OR: 12.70; 95% CI: 1.84–87.70; P=0.010), and AST (OR: 1.08; 95% CI: 1.02–1.16; P=0.017) were associated with high LSM. Conclusion. 11% of psoriatic patients had significant liver fibrosis by high LSM. Waist circumference, diabetes, and AST level were the independent predictors.

Liver Elastography in Healthy Children Using Three Different Systems – How Many Measurements Are Necessary?

2020 ◽  
Author(s):  
Anders Batman Mjelle ◽  
Anesa Mulabecirovic ◽  
Roald Flesland Havre ◽  
Edda Jonina Olafsdottir ◽  
Odd Helge Gilja ◽  
...  
Keyword(s):  
Shear Wave ◽  
Transient Elastography ◽  
Intraclass Correlation ◽  
Age Groups ◽  
Liver Stiffness ◽  
Shear Wave Elastography ◽  
Healthy Children ◽  
Significant Difference ◽  
Pediatric Liver Disease ◽  
Liver Elastography

Abstract Purpose Liver elastography is increasingly being applied in screening for and follow-up of pediatric liver disease, and has been shown to correlate well with fibrosis staging through liver biopsy. Because time is of the essence when examining children, we wanted to evaluate if a reliable result can be achieved with fewer acquisitions. Materials and Methods 243 healthy children aged 4–17 years were examined after three hours of fasting. Participants were divided into four age groups: 4–7 years; 8–11 years; 12–14 years and 15–17 years. Both two-dimensional shear wave elastography (2D-SWE; GE Logiq E9) and point shear wave elastography (pSWE; Samsung RS80A with Prestige) were performed in all participants, while transient elastography (TE, Fibroscan) was performed in a subset of 87 children aged 8–17 years. Median liver stiffness measurement (LSM) values of 3, 4, 5, 6, 7, and 8 acquisitions were compared with the median value of 10 acquisitions (reference standard). Comparison was performed for all participants together as well as within every specific age group. We investigated both the intraclass correlation coefficient (ICC) with absolute agreement and all outliers more than 10 %, 20 % or ≥ 0.5 or 1.0 kPa from the median of 10 acquisitions. Results For all three systems there was no significant difference between three and ten acquisitions, with ICCs ≥ 0.97. All systems needed 4 acquisitions to achieve no LSM deviating ≥ 1.0 kPa of a median of ten. To achieve no LSM deviating ≥ 20 % of a median of ten acquisitions, pSWE and TE needed 4 acquisitions, while 2D-SWE required 6 acquisitions. Conclusion Our results contradict recommendations of 10 acquisitions for pSWE and TE and only 3 for 2D-SWE.

An Analysis on Harmful Alcohol Use and Comparison between One-Person Households and Age Groups

2018 ◽  
Vol 19 (2) ◽  
pp. 39-52 ◽  
Author(s):  
Yerjin Park ◽  
◽  
Areum Oh ◽  
Yumi Oh ◽  
Yuseon Yang
Keyword(s):  
Alcohol Use ◽  
Age Groups ◽  
Harmful Alcohol

2430-PUB: Analysis of Transient Elastography Data and the Risk of Metabolic Syndrome

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2430-PUB
Author(s):  
ZHIMIN HUANG ◽  
WANPING DENG ◽  
HONGYAN CHEN ◽  
KAKA NG ◽  
YANBING LI
Keyword(s):  
Metabolic Syndrome ◽  
Transient Elastography

scholarly journals Microbiota analysis and transient elastography reveal new extra-hepatic components of liver steatosis and fibrosis in obese patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nicolas Lanthier ◽  
Julie Rodriguez ◽  
Maxime Nachit ◽  
Sophie Hiel ◽  
Pierre Trefois ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Transient Elastography ◽  
Fasting Blood Glucose ◽  
Liver Steatosis ◽  
Liver Stiffness ◽  
Multivariate Logistic Regression Analysis ◽  
Rrna Gene ◽  
Obese Patients ◽  
Skeletal Muscle Index ◽  
Linear Discriminant

AbstractObesity could lead to metabolic dysfunction-associated fatty liver disease (MAFLD), which severity could be linked to muscle and gut microbiota disturbances. Our prospective study enrolled 52 obese patients whose MAFLD severity was estimated by transient elastography. Patients with severe steatosis (n = 36) had higher ALAT values, fasting blood glucose levels as well as higher visceral adipose tissue area and skeletal muscle index evaluated by computed tomography. Patients with fibrosis (n = 13) had higher ASAT values, increased whole muscle area and lower skeletal muscle density index. In a multivariate logistic regression analysis, myosteatosis was the strongest factor associated with fibrosis. Illumina sequencing of 16S rRNA gene amplicon was performed on fecal samples. The relative abundance of fecal Clostridium sensu stricto was significantly decreased with the presence of liver fibrosis and was negatively associated with liver stiffness measurement and myosteatosis. In addition, 19 amplicon sequence variants were regulated according to the severity of the disease. Linear discriminant analysis effect size (LEfSe) also highlighted discriminant microbes in patients with fibrosis, such as an enrichment of Enterobacteriaceae and Escherichia/Shigella compared to patients with severe steatosis without fibrosis. All those data suggest a gut-liver-muscle axis in the pathogenesis of MAFLD complications.

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