scholarly journals Mortality in acute pancreatitis with persistent organ failure is determined by the number, type, and sequence of organ systems affected

2021 ◽  
Vol 9 (2) ◽  
pp. 139-149
Author(s):  
Jorge D. Machicado ◽  
Amir Gougol ◽  
Xiaoqing Tan ◽  
Xiaotian Gao ◽  
Pedram Paragomi ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Organ Failure ◽  
Persistent Organ Failure ◽  
Organ Systems

scholarly journals SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study

Gut ◽  
2021 ◽  
pp. gutjnl-2020-323364
Author(s):  
Sanjay Pandanaboyana ◽  
John Moir ◽  
John S Leeds ◽  
Kofi Oppong ◽  
Aditya Kanwar ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Hospital Stay ◽  
Organ Failure ◽  
Collaborative Study ◽  
Length Of Hospital Stay ◽  
Secondary Outcome ◽  
Icu Admission ◽  
Local Complications ◽  
Persistent Organ Failure ◽  
Increased Risk

ObjectiveThere is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.DesignA prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups.Results1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (p<0.001). Unadjusted analysis showed that SARS-CoV-2-positive patients with AP were more likely to require ICU admission (OR 5.21, p<0.001), local complications (OR 2.91, p<0.001), persistent organ failure (OR 7.32, p<0.001), prolonged hospital stay (OR 1.89, p<0.001) and a higher 30-day mortality (OR 6.56, p<0.001). Adjusted analysis showed length of stay (OR 1.32, p<0.001), persistent organ failure (OR 2.77, p<0.003) and 30-day mortality (OR 2.41, p<0.04) were significantly higher in SARS-CoV-2 co-infection.ConclusionPatients with AP and coexistent SARS-CoV-2 infection are at increased risk of severe AP, worse clinical outcomes, prolonged length of hospital stay and high 30-day mortality.

751 A FIVE BIOMARKER PANEL OUTPERFORMS EXISTING EARLY PREDICTORS OF PERSISTENT ORGAN FAILURE IN ACUTE PANCREATITIS

2020 ◽  
Vol 158 (6) ◽  
pp. S-153
Author(s):  
Chris Langmead ◽  
Peter Junwoo Lee ◽  
Pedram Paragomi ◽  
Phil J. Greer ◽  
Kimberly Stello ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Organ Failure ◽  
Biomarker Panel ◽  
Persistent Organ Failure ◽  
Early Predictors

scholarly journals Hemoconcentration is associated with early faster fluid rate and increased risk of persistent organ failure in acute pancreatitis patients

JGH Open ◽  
2020 ◽  
Vol 4 (4) ◽  
pp. 684-691
Author(s):  
Tao Jin ◽  
Lan Li ◽  
Lihui Deng ◽  
Si Wen ◽  
Ruwen Zhang ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Organ Failure ◽  
Persistent Organ Failure ◽  
Increased Risk

Sa1490 Cigarette Smoking is a Risk for Persistent Organ Failure in Patients With Acute Pancreatitis

2012 ◽  
Vol 142 (5) ◽  
pp. S-319 ◽  
Author(s):  
Jeffrey J. Easler ◽  
Venkata Muddana ◽  
Vijay Singh ◽  
Dhiraj Yadav ◽  
David C. Whitcomb ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Cigarette Smoking ◽  
Organ Failure ◽  
Persistent Organ Failure
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