Acacia catechu seed extract provokes cytotoxicity via apoptosis by intrinsic pathway in HepG2 cells

2021 ◽  
Author(s):  
Lakshmi Thangavelu ◽  
Royapuram Veeraragavan Geetha ◽  
Ezhilarasan Devaraj ◽  
Kamal Dua ◽  
Dinesh Kumar Chellappan ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Seed Extract ◽  
Intrinsic Pathway ◽  
Acacia Catechu

Flavonoids of Korean Citrus aurantium L. Induce Apoptosis via Intrinsic Pathway in Human Hepatoblastoma HepG2 Cells

2015 ◽  
Vol 29 (12) ◽  
pp. 1940-1949 ◽  
Author(s):  
Seung Hwan Lee ◽  
Silvia Yumnam ◽  
Gyeong Eun Hong ◽  
Suchismita Raha ◽  
Venu Venkatarame Gowda Saralamma ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Citrus Aurantium ◽  
Intrinsic Pathway

Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells

2013 ◽  
Vol 136 (2) ◽  
pp. 659-667 ◽  
Author(s):  
Paramasivan Poornima ◽  
Robin Sheeba Quency ◽  
Viswandha Vijaya Padma
Keyword(s):  
Reactive Oxygen Species ◽  
Hepg2 Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Intrinsic Pathway

Evaluation of the sub-acute toxicity of Acacia catechu Willd seed extract in a Wistar albino rat model

2020 ◽  
Vol 113 ◽  
pp. 104640
Author(s):  
Lakshmi Thangavelu ◽  
Sri Renukadevi Balusamy ◽  
Rajeshkumar Shanmugam ◽  
Senthilkumar Sivanesan ◽  
Ezhilarasan Devaraj ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Rat Model ◽  
Seed Extract ◽  
Albino Rat ◽  
Acacia Catechu

scholarly journals Chitopentaose inhibits hepatocellular carcinoma by inducing mitochondrial mediated apoptosis and suppressing protective autophagy

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Chunfeng Zhu ◽  
Mengyao Zhao ◽  
Liqiang Fan ◽  
Xuni Cao ◽  
Quanming Xia ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Membrane Potential ◽  
Cell Viability ◽  
Mtt Assay ◽  
Hepg2 Cells ◽  
Mitochondrial Membrane ◽  
Molecular Mechanisms ◽  
Degree Of Polymerization ◽  
Intrinsic Pathway ◽  
Autophagy Flux

AbstractHepatocellular carcinoma (HCC) is one of the most prevalent and deadliest cancers. In this study, the anti-tumor effect of singular degree of polymerization (DP) chitooligosaccharides (COS) (DP 2–5) and the underlay molecular mechanisms were investigated on HCC cell line HepG2. MTT assay showed that (GlcN)5 have the best anti-proliferation effect among the different DP of COS (DP2-5). Furthermore, the administration of (GlcN)5 could decrease mitochondrial membrane potential, release cytochrome c into cytoplasm, activate the cleavage of Caspases9/3, thus inducing mitochondrial-mediated apoptosis in HepG2 cells (accounting for 24.57 ± 2.25%). In addition, (GlcN)5 treatment could increase the accumulation of autophagosomes. Further investigation showed that (GlcN)5 suppressed protective autophagy at the fusion of autophagosomes and lysosomes. Moreover, the inhibition of protective autophagy flux by (GlcN)5 could further decrease cell viability and increase the apoptosis rate. Our findings suggested that (GlcN)5 suppressed HepG2 proliferation through inducing apoptosis via the intrinsic pathway and impairing cell-protective autophagy. COS might have the potential to be an agent for lowering the risk of HCC.

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