Effect of prenatal exposure to Benzo[a]pyrene on ovarian toxicity and reproductive dysfunction: Protective effect of atorvastatin in the embryonic period

2021 ◽  
Author(s):  
Zahra Rahmani ◽  
Abbasali Karimpour Malekshah ◽  
Mehryar Zargari ◽  
Fereshteh Talebpour Amiri
Keyword(s):  
Protective Effect ◽  
Prenatal Exposure ◽  
Reproductive Dysfunction ◽  
Ovarian Toxicity ◽  
Embryonic Period

scholarly journals Protective effect of alpha-lipoic acid and omega-3 fatty acids against cyclophosphamide-induced ovarian toxicity in rats

2020 ◽  
Vol 13 (1) ◽  
pp. 188-196 ◽  
Author(s):  
Dhanya Venugopalan Nair ◽  
M. Usha Rani ◽  
A. Gopala Reddy ◽  
B. Kala Kumar ◽  
M. Anudeep Reddy ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Protective Effect ◽  
Estrous Cycle ◽  
Tnf Alpha ◽  
Alpha Lipoic Acid ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Ovarian Toxicity ◽  
Transmission Electron ◽  
Group Ii

Background and Aim: Cyclophosphamide therapy is known to be associated with the risk of female infertility as a result of ovarian toxicity. Alpha-lipoic acid (LA) and omega-3 fatty acids are known for their antioxidant and anti-inflammatory activities. The present study investigated the potential protective effect of alpha-LA, omega-3 fatty acids, and its combination against cyclophosphamide-induced ovarian toxicity in rats. Materials and Methods: Thirty rats were equally divided into Groups I, II, III, IV, and V. Group I was normal control, wherein the rats were fed with normal feed and water ad libitum. Group II served as cyclophosphamide-induced group, wherein the rats were injected with cyclophosphamide at 75 mg/kg through intraperitoneal route once a week to induce ovarian toxicity. Groups III and IV were treated with alpha-LA at the rate of 25 mg/kg and omega-3 fatty acids at the rate of 400 mg/kg, respectively, in parallel to cyclophosphamide induction as in Group II. Group V animals were coadministered with alpha-LA (25 mg/kg) and omega-3 fatty acids (400 mg/kg) along with cyclophosphamide induction as in Group II. The respective treatments were administered daily through oral route for a period of 30 days. Regularity of estrous cycle was evaluated by vaginal cytology. Post-treatment period, the animals were humanely sacrificed, and the blood samples were subjected to the estimation of follicle-stimulating hormone (FSH) and estrogen. The ovarian tissue was weighed and subjected to histopathology, transmission electron microscopy, estimation of decreased glutathione (GSH), and tumor necrosis factor (TNF)-alpha. Results: Rats treated with cyclophosphamide alone manifested irregularity in estrous cycle, increased FSH, and reduced estrogen levels. The ovaries showed decreased GSH and increased TNF-alpha concentrations. Histopathological and transmission electron microscopic analysis of the ovarian follicles revealed degenerative changes. Administration of alpha-LA and omega-3 fatty acids as well as the combination of both the treatments demonstrated significant normalization of the estrous cycle and antioxidant defense mechanism as well as ameliorated the hormonal profile and histological architecture of the ovarian follicles. However, appreciable synergistic efficacy of the combination therapy (alpha-LA+omega-3 fatty acids) with respect to the monotherapies was not observed in the present study. Conclusion: The efficacy of alpha-LA and omega-3 fatty acids against cyclophosphamide-induced ovarian toxicity could be attributed to its antioxidant and anti-inflammatory activities that prevented the oxidative damage to the ovaries caused by cyclophosphamide. Hence, our findings suggest that dietary supplementation of alpha-LA and omega-3 fatty acids in women receiving cyclophosphamide therapy could carry potential benefits in preventing cyclophosphamide-induced infertility in childbearing women.

Protective effect of oxytocin on a methotrexate-induced ovarian toxicity model

2020 ◽  
Vol 301 (5) ◽  
pp. 1317-1324 ◽  
Author(s):  
Ismet Hortu ◽  
Gokay Ozceltik ◽  
Ahmet Mete Ergenoglu ◽  
Gurkan Yigitturk ◽  
Ozum Atasoy ◽  
...  
Keyword(s):  
Protective Effect ◽  
Ovarian Toxicity

Protective Effect of Rosmarinus officinalis Flavonoids Rich Fractions Against Testicular and Reproductive Dysfunction in Streptozotocin-induced Diabetic Mice

2020 ◽  
Vol 13 (2) ◽  
pp. 194-200
Author(s):  
Messaoud Belmouhoub ◽  
Alla-Eddine Khellouf ◽  
Zakia Ouatah ◽  
Ouassila Belkacem ◽  
Souhila Djermoune ◽  
...  
Keyword(s):  
Protective Effect ◽  
Rosmarinus Officinalis ◽  
Diabetic Mice ◽  
Reproductive Dysfunction

The Protective Effect of α-Tocopherol on the Content of Selected Elements in the Calvaria for Exposed Hens to TCDD in the Early Embryonic Period

2018 ◽  
Vol 190 (2) ◽  
pp. 517-525 ◽  
Author(s):  
Maciej Dobrzynski ◽  
Piotr Kuropka ◽  
Malgorzata Tarnowska ◽  
Marzena Styczynska ◽  
Krzysztof Dudek ◽  
...  
Keyword(s):  
Protective Effect ◽  
Embryonic Period

Effect of prenatal exposure to ethanol on hepatic elongation factor-2 and proteome in 21 d old rats: protective effect of folic acid

2003 ◽  
Vol 35 (4) ◽  
pp. 428-437 ◽  
Author(s):  
S García-Rodríguez ◽  
S Argüelles ◽  
R Llopis ◽  
M.L Murillo ◽  
A Machado ◽  
...  
Keyword(s):  
Folic Acid ◽  
Protective Effect ◽  
Prenatal Exposure ◽  
Elongation Factor ◽  
Elongation Factor 2 ◽  
Old Rats
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