Propolis alleviates 4‐aminobiphenyl‐induced oxidative DNA damage by inhibition of CYP2E1 expression in human liver cells

2021 ◽  
Author(s):  
Eva Ari Wahyuni ◽  
Chien Yi Chen ◽  
Huery Nuo Wu ◽  
Chih‐Ching Chien ◽  
Ssu‐Ching Chen
Keyword(s):  
Dna Damage ◽  
Human Liver ◽  
Oxidative Dna Damage ◽  
Liver Cells ◽  
Human Liver Cells ◽  
Cyp2e1 Expression

TiO2nanoparticles induce oxidative DNA damage and apoptosis in human liver cells

2011 ◽  
Vol 7 (1) ◽  
pp. 48-60 ◽  
Author(s):  
Ritesh K Shukla ◽  
Ashutosh Kumar ◽  
Deepak Gurbani ◽  
Alok K. Pandey ◽  
Shashi Singh ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Liver ◽  
Oxidative Dna Damage ◽  
Liver Cells ◽  
Human Liver Cells

Histone demethylase JHDM2A regulates H3K9 dimethylation in response to arsenic‐induced DNA damage and repair in normal human liver cells

2020 ◽  
Vol 40 (12) ◽  
pp. 1661-1672
Author(s):  
An‐liu Zhang ◽  
Shun‐fang Tang ◽  
Yue Yang ◽  
Chang‐zhe Li ◽  
Xue‐jiao Ding ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Liver ◽  
Liver Cells ◽  
Histone Demethylase ◽  
Dna Damage And Repair ◽  
Human Liver Cells ◽  
Normal Human Liver ◽  
Normal Human ◽  
H3k9 Dimethylation

scholarly journals Histone demethylase JHDM2A regulates H3K9 dimethylation in response to arsenic‐induced DNA damage and repair in normal human liver cells

2021 ◽  
Vol 41 (4) ◽  
pp. 650-650
Author(s):  
An‐liu Zhang ◽  
Shun‐fang Tang ◽  
Yue Yang ◽  
Chang‐zhe Li ◽  
Xue‐jiao Ding ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Liver ◽  
Liver Cells ◽  
Histone Demethylase ◽  
Dna Damage And Repair ◽  
Human Liver Cells ◽  
Normal Human Liver ◽  
Normal Human ◽  
H3k9 Dimethylation

AAnti-Inflammatory Effects of Plasma Circulating Exosomes Obtained from Normal-Weight and Obese Subjects on Hepatocytes

2020 ◽  
Vol 20 ◽  
Author(s):  
Reza Afrisham ◽  
Sahar Sadegh-Nejadi ◽  
Reza Meshkani ◽  
Solaleh Emamgholipour ◽  
Molood Bagherieh ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Liver Cells ◽  
Normal Weight ◽  
Protein Levels ◽  
Human Liver Cells ◽  
Tnf Α ◽  
Anti Inflammatory

Introduction: Obesity is a disorder with low-grade chronic inflammation that plays a key role in the hepatic inflammation and steatosis. Moreover, there are studies to support the role of exosomes in the cellular communications, the regulation of metabolic homeostasis and immunomodulatory activity. Accordingly, we aimed to evaluate the influence of plasma circulating exosomes derived from females with normal-weight and obesity on the secretion of inflammatory cytokines in human liver cells. Methods: Plasma circulating exosomes were isolated from four normal (N-Exo) and four obese (O-Exo) women. The exosomes were characterized and approved for CD63 expression (common exosomal protein marker) and morphology/size using the western blot and TEM methods, respectively. The exosomes were used for stimulation of HepG2 cells in vitro. After 24 h incubation, the protein levels of TNF-α,IL-6, and IL-1β were measured in the culture supernatant of HepG2 cells using the ELISA kit. Results: The protein levels of IL-6 and TNF-α in the cells treated with O-Exo and N-Exo reduced significantly in comparison with control group (P=0.039 and P<0.001 respectively), while significance differences were not found between normal and obese groups (P=0.808, and P=0.978 respectively). However, no significant differences were found between three groups in term of IL-1β levels (P=0.069). Based on the correlation analysis, the protein levels of IL-6 were positively correlated with TNF-α (r 0.978, P<0.001). Conclusion: These findings suggest that plasma circulating exosomes have probably anti-inflammatory properties independently from body mass index and may decrease the secretion of inflammatory cytokines in liver. However, further investigations in vitro and in vivo are needed to address the anti-inflammatory function of N-Exo and O-Exo in human liver cells and/or other cells.

The CAT-Tox (L) Assay: A Sensitive and Specific Measure of Stress-Induced Transcription in Transformed Human Liver Cells

1995 ◽  
Vol 28 (1) ◽  
pp. 118-128 ◽  
Author(s):  
MARQUÉ D. TODD ◽  
MICHAEL J. LEE ◽  
JULIE L. WILLIAMS ◽  
JOHN M. NALEZNY ◽  
PAULINE GEE ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Cells ◽  
Specific Measure ◽  
Human Liver Cells
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